Results 51 to 60 of about 3,249,481 (296)

Nucleosome proteostasis and histone turnover

Frontiers in Molecular Biosciences, 2022
Maintenance of protein folding homeostasis, or proteostasis is critical for cell survival as well as for execution of cell type specific biological processes such as muscle cell contractility, neuronal synapse and memory formation, and cell transition ...
Adrian Arrieta, Thomas M. Vondriska, Thomas M. Vondriska, Thomas M. Vondriska   +3 more
doaj   +1 more source

Chromatin profiling in model organisms [PDF]

Briefings in Functional Genomics and Proteomics, 2007
The correct control of gene expression is essential for the proper development of organisms. Abnormal expression of genes can lead to cancerous growth and certain diseases. To understand how gene expression is controlled on a genome-wide scale, methods for assaying transcription factor binding sites are required. There are two prevailing techniques for
Tony D, Southall, Andrea H, Brand
openaire   +2 more sources

Targeted deficiency of the transcriptional activator Hnf1 alpha alters subnuclear positioning of its genomic targets [PDF]

, 2008
DNA binding transcriptional activators play a central role in gene-selective regulation. In part, this is mediated by targeting local covalent modifications of histone tails.
Luco, Reini F., Sadoni, Nicolas, Maestro, Miguel A., Miguel A Maestro, Luco Reini F., Ferrer Jorge, Zink Daniele, Daniele Zink, Sadoni Nicolas, Nicolas Sadoni, Jorge Ferrer, Maestro Miguel A., Ferrer, Jorge, Reini F Luco, Zink, Daniele   +14 more
core   +2 more sources

Chromatin structure in situ: the contribution of DNA ultrastructural cytochemistry

European Journal of Histochemistry, 2014
Ultrastructural studies conducted in situ using conventional transmission electron microscopy have had relatively little impact on defining the structural organization of chromatin. This is due to the fact that in routine transmission electron microscopy,
M. Derenzini, A. L. Olins, D. E. Olins
doaj   +1 more source

Stress as a Chromatin Landscape Architect

Frontiers in Cell and Developmental Biology, 2021
The exponential development of methods investigating different levels of spatial genome organization leads to the appreciation of the chromatin landscape's contribution to gene regulation and cell fate.
Anastassiia Vertii
doaj   +1 more source

Genome wide nucleosome landscape shapes 3D chromatin organization. [PDF]

Sci Adv
The hierarchical chromatin organization begins with formation of nucleosomes, which fold into chromatin domains punctuated by boundaries and ultimately chromosomes. In a hierarchal organization, lower levels shape higher levels.
Fouziya S, Krietenstein N, Mir US, Mieczkowski J, Khan MA, Baba A, Dar MA, Altaf M, Wani AH.   +8 more
europepmc   +2 more sources

Chromatin Meets Its Organizers [PDF]

Cell, 2013
Chromatin organization and gene-gene interactions are critical components of carrying out developmental programs. Phillips-Cremins et al. identify a series of unexpected architectural proteins that work in a combinatorial manner to functionally organize chromatin in a cell-type-specific manner at the submegabase-length scale.
Bodnar, Megan S., Spector, David L.
openaire   +2 more sources

Dynamic chromatin: concerted nucleosome remodelling and acetylation [PDF]

, 2005
The flexibility of chromatin that enables translation of environmental cues into changes in genome utilisation, relies on a battery of enzymes able to modulate chromatin structure in a highly targeted and regulated manner.
Eberharter, Anton, Becker, Peter, Ferreira, Roger   +2 more
core   +1 more source

FACS-based isolation of fixed mouse neuronal nuclei for ATAC-seq and Hi-C

STAR Protocols, 2021
Summary: The organization of chromatin structure plays a crucial role in gene expression, DNA replication, and repair. Chromatin alterations influence gene expression, and modifications could be associated with genomic instability in the cells during ...
Ekaterina Eremenko, Anastasia Golova, Daniel Stein, Monica Einav, Ekaterina Khrameeva, Debra Toiber   +5 more
doaj   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source