Results 111 to 120 of about 37,025 (306)

Aligning with the 3Rs: alternative models for research into muscle development and inherited myopathies

BMC Veterinary Research
Inherited and acquired muscle diseases are an important cause of morbidity and mortality in human medical and veterinary patients. Researchers use models to study skeletal muscle development and pathology, improve our understanding of disease ...
Hashir Mehmood, Paul R Kasher, Richard Barrett-Jolley, Gemma L. Walmsley   +3 more
semanticscholar   +1 more source

Lung maneuvers of large amplitudes for probing physiological alterations in mouse models of asthma

Animal Models and Experimental Medicine, EarlyView.
Lung maneuvers of small amplitudes, such as the ones performed in oscillometry, are the current gold standard to probe lung mechanics in animals, but they are insensitive to detect baseline physiological alterations in mouse models of asthma. Herein, lung maneuvers of different amplitudes were compared in two mouse models of asthma.
Magali Boucher, Cyndi Henry, Marie‐Josée Beaulieu, Andrés Rojas‐Ruiz, Ynuk Bossé   +4 more
wiley   +1 more source

Sex as a biological variable in nonclinical studies: Bridging scientific rigor, animal welfare, and regulatory expectations

Animal Models and Experimental Medicine, EarlyView.
Sex as a biological variable (SABV) is a critical determinant of pharmacokinetics, pharmacodynamics, and toxicity in nonclinical studies. This review highlights how inappropriate neglect of sex differences compromises animal welfare, scientific reproducibility, and regulatory compliance.
Kenta Onuma, Masaki Watanabe, Nobuya Sasaki   +2 more
wiley   +1 more source

Dopaminergic Regulation of Reward System Connectivity Underpins Pain and Emotional Suffering in Migraine

Journal of Pain Research, 2021
Dajung J Kim, Hassan Jassar, Manyoel Lim, Thiago D Nascimento, Alexandre F DaSilva Headache and Orofacial Pain Effort (H.O.P.E.), Biologic and Material Sciences & Prosthodontics, University of Michigan School of Dentistry, Ann Arbor, MI, 48109 ...
Kim DJ, Jassar H, Lim M, Nascimento TD, DaSilva AF   +4 more
doaj  

Risks, alternative knowledge strategies and democratic legitimacy: the conflict over co-incineration of hazardous industrial waste in Portugal. [PDF]

, 2011
The decision to incinerate hazardous industrial waste in cement plants (the socalled ‘co-incineration’ process) gave rise to one of the most heated environmental conflicts ever to take place in Portugal. The bitterest period was between 1997 and 2002,
Alam T., Alexander J.C., Barker A., Beck U., Boehmer-Christiansen S., Cohen B., Collingridge D., Edelstein M.R., Fischer F., Formosinho S., Gigerenzer G., Godard O., Hacking I., Hacking I., Helena Mateus Jerónimo, Hilgartner S., Jasanoff S., Jerónimo H.M., Jerónimo H.M., José Luís Garcia, Kasperson R.E., Kasperson R.E., Keynes J.M., Knight F.H., Krüger L., Lacey H., Lacey H., Larson M.S., Liberatore A., Martins H., Mazur A., Nelkin D., Nowotny H., Petts J., Porter T.M., Primack J., Roqueplo P., Rosanvallon P., Rosanvallon P., Roy A., Tilly C., Vari A.   +41 more
core   +1 more source

Research progress in animal models of dry eye disease: Types, mechanisms, and application prospects

Animal Models and Experimental Medicine, EarlyView.
Pivotal multifactorial animal models for translational dry eye disease research. Abstract Dry eye disease (DED) is a prevalent and complex multifactorial ocular surface disorder, leading to significant visual discomfort and diminished quality of life.
Jinshen Liu, Jiaqi Chen, Zhonghui Li, Jiamin Zhou, Hui Zhang, Yujia Yu, Feng Cheng, Jie Bao, Chunhan Feng, Xiangqu Yu, Zhao Xia, Rao Ding, Xiang Li   +12 more
wiley   +1 more source

Inteins: Localized Distribution, Gene Regulation, and Protein Engineering for Biological Applications

Microorganisms, 2018
Inteins are self-splicing polypeptides with an ability to excise themselves from flanking host protein regions with remarkable precision; in the process, they ligate flanked host protein fragments.
Theetha L. Pavankumar
doaj   +1 more source

Descriptive, comparative, and functional anatomy of the facial musculature in cattle (Bos taurus)

The Anatomical Record, EarlyView.
Abstract Facial expressions can provide insight into animal emotions and pain, but no standardized system for assessing the entire facial display in cattle (Bos taurus Linnaeus) exists. The Facial Action Coding System (FACS), originally developed for humans, identifies distinct facial movements based on mimetic muscles.
Maja Söderlind, Bridget Cain, Katrina Ask, Jean‐Francois Valarcher, Elin Hernlund, Pia Haubro Andersen, Marie Rhodin   +6 more
wiley   +1 more source

General analysis of the rare Bc->D^*_s l^+ l^- decay beyond the standard model

, 2007
The general analysis of the rare Bc->D^*_s l^+ l^- decay is presented by using the most general, model independent effective Hamiltonian. The dependencies of the branching ratios, longitudinal, normal and transversal polarization asymmetries for l^- and ...
A. Abulencia, A. Ali, A. Ali, A. Faessler, A.J. Buras, B. Aubert, C.-S. Huang, C.Q. Geng, D. Guetta, F. Abe, F. Abe, F. Krüger, F. Krüger, G. Turan, J.L. Hewett, K. Abe, M. Misiak, M. Misiak, M.A. Ivanov, M.S. Alam, P. Colangelo, P. Colangelo, P. Colangelo, Q.-S. Yan, S. Fukae, T.M. Aliev, T.M. Aliev, T.M. Aliev, T.M. Aliev, U.O. Yilmaz, Y.G. Kim   +30 more
core   +1 more source

PEPITEM Regulates the Synovial Microenvironment During Immune‐Mediated Inflammatory Arthritis to Limit Disease

Arthritis &Rheumatology, EarlyView.
Objective Here we investigate the status of the adiponectin–PEPITEM pathway in early, treatment naive rheumatoid arthritis (RA) and psoriatic arthritis (PsA) and the therapeutic efficacy of PEPITEM administration in preclinical models. Methods Peripheral blood was isolated from patients with clinical suspect arthralgia and suspected inflammatory ...
Mussarat Wahid, Samuel Kemble, Oladimeji Abudu, Anella Saviano, Christopher Mahony, Jonathan W. Lewis, Thomas A. Nicholson, Anna Schettino, Noemi Marigliano, Kathryn Frost, Jenefa Begum, Alyssa M. Urbanowski, Marion Limo, Rakesh Jha, Sandra Martinez Jarquin, Laleh Pezhman, Abbie E. A. Degan, Amy E. Anderson, Charlotte G. Smith, Armaiti Batki, Holly Adams, Francesco Caso, Raffaele Scarpa, Iain McInnes, Stefan Siebert, Arthur G. Pratt, Andrew Filer, Karim Raza, Adam P. Croft, Myriam Chimen, Felicity de Cogan, G. Ed Rainger, Asif J. Iqbal, Francesco Maione, Helen M. McGettrick   +34 more
wiley   +1 more source