Results 111 to 120 of about 13,325 (255)

3Rs search strategies for PubMed

A series of search strategies requested by the Crick's head of BRF licencing and compliance. Strategies have been generated for common animal models used in life sciences and all aspects of 3Rs.
Patricia Biggs (7560236)
core   +1 more source

TPS 3Rs: Reading, Racial Equity, Relationships

, 2021
The Pittsburgh Study Early-School-Age Cohort (TPS 3Rs: Reading, Racial Equity, Relationships) is developing an ecosystem intervention to enhance K-3rd grade literacy that centers on Black children.
Wanless, Shannon, Moye, Shallegra, Orman, Meghan, Geibel, Sharon   +3 more
core  

Cannabigerol reverses mechanical allodynia through α2A‐adrenergic modulation of thalamocortical signaling in chemotherapy‐induced neuropathy

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Chemotherapy‐induced peripheral neuropathy (CIPN) is a prevalent and treatment‐resistant side effect of platinum‐based chemotherapy, characterised by mechanical allodynia. Cannabigerol (CBG), a non‐psychoactive cannabinoid, has shown antinociceptive potential, but its site and mechanism of action remain unclear.
Quinn W. Wade, Nathan Morris, Diana E. Sepulveda, Alonso Cortez‐Resendiz, Christopher Brandl, Jennifer E. Lausch, Mariya Starostina, Nicholas M. Graziane   +7 more
wiley   +1 more source

Auditoría de certificación Sostenibilidad 3Rs : informe de resultados

El informe documenta los resultados de la auditoría de seguimiento para la certificación Sostenibilidad 3Rs realizada al Ministerio de Economía, Planificación y Desarrollo (MEPyD) de la República Dominicana en julio de 2024.
Sostenibilidad 3Rs&Es
core  

Schedule‐dependent neuroprotection by pioglitazone in a novel model of α‐synucleinopathy in rats: Integrated behavioural and histological outcomes

British Journal of Pharmacology, EarlyView.
Background and Purpose α‐Synucleinopathies are neurodegenerative disorders characterized by the aggregation and propagation of misfolded α‐synuclein. In Parkinson's disease (PD), the most common α‐synucleinopathy, the progression of motor and nonmotor deficits, and dopaminergic neuron loss, are closely linked to the spreading of misfolded α‐synuclein ...
Alberto Santiago‐Balmaseda, Marcos M. Villegas‐Rojas, Isaac Pérez‐Segura, Maricela Espino‐Cambrón, Daniel Martinez‐Fong, Luis O. Soto‐Rojas   +5 more
wiley   +1 more source

Las 3Rs : reducir, reusar, reciclar [PDF]

, 2015
Esta guía tiene por objeto concientizar sobre los residuos sólidos, su generación, su manejo y su impacto ambiental, basándose para ello en los principios de la cultura 3Rs.
Mirabal, Marbellis (coord.), Heinsen, Virginia (coord.), Méndez, María Teresa (coord.)   +2 more
core  

Prevention of microglial activation and postoperative cognitive deficits by positive allosteric modulation of α5‐GABAA receptors

British Journal of Pharmacology, EarlyView.
Background and Purpose Long‐lasting cognitive deficits after surgery in aged individuals, referred to as perioperative neurocognitive disorder (NCD), are a significant public health concern. Such postoperative cognitive deficits are dependent on the presence of microglia in the brain, which, when activated, trigger neuroinflammation.
Jinrui Lyu, Rajasekar Nagarajan, Dishary Sharmin, Prithu Mondal, Maltesh Kambali, Muxiao Wang, Jinyan Zhou, Makoto Inoue, James M. Cook, Uwe Rudolph   +9 more
wiley   +1 more source

Insights into bone and cartilage responses to pulsed electromagnetic field stimulation: a review with quantitative comparisons

Frontiers in Bioengineering and Biotechnology
Bone fractures and cartilage pathologies represent a heavy socioeconomic burden for the national healthcare systems worldwide. Pulsed electromagnetic field (PEMF) stimulation has become a widely recognized treatment for enhancing bone fracture healing ...
Beatrice Masante, Beatrice Masante, Stefano Gabetti, Stefano Gabetti, Joao C. Silva, Joao C. Silva, Giovanni Putame, Giovanni Putame, Simone Israel, Simone Israel, Cristina Bignardi, Cristina Bignardi, Diana Massai, Diana Massai   +13 more
doaj   +1 more source

The role of organizational culture in compliance with the principles of the 3Rs

, 2010
In order for their research to be legitimate, scientists carrying out research using animals must comply with rules and regulations. The 3Rs (replacement, reduction and refinement) are one set of guidelines that help to promote the ethical use of animals
Anne-Grethe Trønsdal Berg, Berg, Anne-Grethe Trønsdal, Brønstad, Aurora, Aurora Brønstad   +3 more
core   +1 more source

Shared and specific molecular mechanisms of proteasome inhibitors in chemotherapy‐induced peripheral neurotoxicity

British Journal of Pharmacology, EarlyView.
This study compares the molecular mechanisms of chemotherapy‐related peripheral neurotoxicity of two proteasome inhibitors, bortezomib and carfilzomib, using a multidisciplinary approach to reveal that, alongside shared effects on mitochondria structure and function, the more neurotoxic drug BTZ has specific effects on microtubules and mitochondrial ...
Federico Iseppon, Alessio Malacrida, Alessia Chiorazzi, Annalisa Canta, Paola Alberti, Valentina Alda Carozzi, Eleonora Pozzi, Virginia Rodriguez‐Menendez, Laura Cherchi, Valentina Fabbro, Lisa Pagani, Elisa Tonelli, Laura Tapella, Andrea Mattarei, Sara Palermo, Daniele Cartelli, Mario Mauri, Noemi Scimia, Serena Stanga, Dmitry Lim, Carla Distasi, Marta Delconti, Clizia Chinello, Patricia Morcillo, Maria Elena Pero, Francesca Bartolini, Guido Cavaletti, Cristina Meregalli   +27 more
wiley   +1 more source