Results 131 to 140 of about 13,325 (255)

Aligned polycaprolactone/polyaniline electrospun nanofibers for directing neural stem cell differentiation and neuron arrangement

Frontiers in Biomaterials Science
The use of engineered biomimetic substrates combined with neural stem cells (NSCs) constitutes a promising approach to develop reliable in vitro models of the nervous tissue.
Michela Licciardello, Michela Licciardello, Michela Licciardello, Cecilia Traldi, Cecilia Traldi, Cecilia Traldi, Matteo Bortolameazzi, Matteo Bortolameazzi, Matteo Bortolameazzi, Daniele Testore, Daniele Testore, Daniele Testore, Gianluca Ciardelli, Gianluca Ciardelli, Gianluca Ciardelli, Gianluca Ciardelli, Chiara Tonda-Turo, Chiara Tonda-Turo, Chiara Tonda-Turo   +18 more
doaj   +1 more source

Dynamic Capabilities as Drivers of Circular Business Models: Exploring Direct and Indirect Relationships

Journal of Product Innovation Management, EarlyView.
ABSTRACT Academic Summary Despite the urgent need for a circular economy, firms' transition from linear to circular business models (CBMs) remains slow. While previous research suggests that dynamic capabilities are the key drivers of this transition, it assumes a direct link, overlooking that these capabilities can facilitate change but do not ...
Jörn Block, Thomas Clauss, Matheus Franco, Timo Lemcke, Hubert Speth   +4 more
wiley   +1 more source

Considering aspects of the 3Rs principles within experimental animal biology

, 2017
The 3Rs – Replacement, Reduction and Refinement – are embedded into the legislation and guidelines governing the ethics of animal use in experiments.
Bury, Nic, Sneddon, Lynne U., Lewis G. Halsey, Sneddon, Lynne, Halsey, Lewis G., Bury, Nic R., Halsey, Lewis, Nic R. Bury, Lynne U. Sneddon   +8 more
core   +1 more source

Feeding Laboratory Mice: Comparing a Standard Versus a Purified Diet – Marked Effects on Digestive Physiology

Journal of Animal Physiology and Animal Nutrition, EarlyView.
ABSTRACT Diet composition and processing have a major impact on its utilisation by the animal, as is known from farm and pet animal species. This includes effects on energy and nutrient digestibility, the intermediary metabolism, and the intestinal microbiome, with all the resulting impacts. For laboratory animals, data is scarce on influencing factors
L. F. Böswald, A. Zeyner, M. M. Santo, M. Wensch‐Dorendorf, A. Sünder, B. Popper, W. Siegert   +6 more
wiley   +1 more source

Linking One Health to 3R. Culture of Care as a bridge towards Russell and Burch's highest goal: Replacement

Journal of Animal Law, Ethics and One Health
Animal testing has long been ethically controversial, initially due to religious and cultural beliefs and increasingly because of the obvious suffering inflicted.
Katharina Ameli, Eva Raimann, Jaqueline Krüger, Stephanie Krämer   +3 more
doaj   +1 more source

The 3Rs in research: a contemporary approach to replacement, reduction and refinement

, 2017
First promulgated in 1959, the 3Rs of Replacement, Reduction and Refinement have evolved as fundamental principles underlying the use of animals and alternatives in science throughout the modern world.
Judy MacArthur Clark
core   +1 more source

Extrusion and Pancreatin Superdosing Modulate the Metabolic Impact of 20% Chlorella vulgaris Inclusion in Broiler Diets

Journal of Animal Physiology and Animal Nutrition, EarlyView.
ABSTRACT Microalgae such as Chlorella vulgaris are gaining attention as sustainable and nutritionally valuable feed ingredients, with the potential to partially replace soybean meal in broiler diets. However, dietary inclusion of 20% C. vulgaris has been attempted, but negatively affected growth performance due to limited digestibility.
Ana Rita Mendes, Cátia Falcão Martins, Maria Pinheiro Spínola, Daniela Filipa Pires Carvalho, Obete Madacussengua, Joana Inês Ferreira, Ana Maria Fontes, Rui Manuel Amaro Pinto, Miguel Pedro Mourato, Adam Davis, André Martinho de Almeida, Madalena Lordelo, José António Mestre Prates   +12 more
wiley   +1 more source

Rethinking the 3Rs: From Whitewashing to Rights

, 2019
Few other issues have prompted as many legislators to adopt legal instruction on the “proper” use of non-human animals (hereinafter referred to as animals) in medical and scientific research.
Blattner, Charlotte E.
core  

Pharmacokinetics of Long‐Acting Ampicillin and Its Impact on the Gut Microbiome and Resistome in Rhesus Macaques (Macaca mulatta)

Journal of Veterinary Pharmacology and Therapeutics, EarlyView.
ABSTRACT Injectable antimicrobials with documented prolonged dosing intervals (> 48 h) for use in rhesus macaques are sparse. The objective of our study was to assess the pharmacokinetics, urine excretion, and effects on gut microbiome and resistome of intramuscular administered long‐acting formulation of ampicillin (Albipen LA) in macaques.
Annemiek Maaskant, Ingeborg M. van Geijlswijk, Mathias Devreese, Marc Cherlet, Leo F. van Geest, Jaap A. Wagenaar, Jan A. M. Langermans, Aldert L. Zomer, Jaco Bakker, Ronette Gehring   +9 more
wiley   +1 more source

Big data and its impact on the 3Rs: a home cage monitoring oriented review. [PDF]

Undisturbed home cage recording of mouse activity and behavior has received increasing attention in recent years. In parallel, several technologies have been developed in a bid to automate data collection and interpretation.
De Girolamo, Paolo, O'Connor, Eoin C, D'Angelo, Livia, Fuochi, Sara, Rigamonti, Mara   +4 more
core   +1 more source