Results 131 to 140 of about 14,239 (267)

Collagen Type VI Alpha 1 as a Regulator of Redox Homeostasis in Antioxidant‐Enhanced Osteogenesis of Dental Stem Cells

Cell Proliferation, EarlyView.
Under physiological conditions, NAC activates the PI3K‐AKT‐COL6A1 axis to sustain redox balance and enhance osteogenesis. COL6A1 deficiency, however, compromises this axis, inducing oxidative stress and impairing NAC's osteogenic efficacy. ABSTRACT Alveolar bone injury represents a prevalent clinical challenge in dentistry, for which stem cell‐based ...
Zhaosong Meng, Jiacheng Liu, Yue Zhang, Ruimeng Yang, Jingyi Zhang, Haosun Yang, Zheng Wang, Ran Wei, Zhe Li, Shuling Guo, Lizhi Hu, Lei Sui   +11 more
wiley   +1 more source

Optimal Hypoxia Mimetic Small Molecules for Enhancing Angiogenic Properties of Stem Cells From Human Exfoliated Deciduous Teeth

International Endodontic Journal, EarlyView.
ABSTRACT Aim Hypoxic preconditioning of cells holds promise for regenerative therapies, yet identifying effective and safe methods for clinical application remains challenging. We aimed to determine optimal hypoxia‐mimetic small molecules (SMs) that stabilize hypoxia‐inducible factor‐1α (HIF‐1α) and their dosages for hypoxic preconditioning in stem ...
Hong Wang, Jiawei Liu, Xintao Yang, Mohamad Koohi‐Moghadam, Shuting Gao, Yuanyuan Han, Dineshi Sewvandi Thalakiriyawa, James Kit Hon Tsoi, Yanqi Yang, Waruna Lakmal Dissanayaka   +9 more
wiley   +1 more source

Linking One Health to 3R. Culture of Care as a bridge towards Russell and Burch's highest goal: Replacement

Journal of Animal Law, Ethics and One Health
Animal testing has long been ethically controversial, initially due to religious and cultural beliefs and increasingly because of the obvious suffering inflicted.
Katharina Ameli, Eva Raimann, Jaqueline Krüger, Stephanie Krämer   +3 more
doaj   +1 more source

Horizontal Ridge Augmentation Using an rhBMP‐2 Loaded Volume‐Stable Collagen Matrix Compared to Guided Bone Regeneration: A Preclinical In Vivo Study

Journal of Clinical Periodontology, EarlyView.
ABSTRACT Aim To investigate whether incorporation of recombinant human bone morphogenetic protein‐2 (rhBMP‐2) into a volume‐stable collagen matrix (VCMX) enhances horizontal ridge augmentation compared with VCMX alone or guided bone regeneration (GBR). Methods Chronic horizontal ridge defects were created in five canines.
Jin‐Young Park, Gi‐Seo Song, Seung‐Hyun Park, Lorenzo Tavelli, David T. Wu, Daniel S. Thoma, Ronald E. Jung, Ui‐Won Jung, Jae‐Kook Cha   +8 more
wiley   +1 more source

Fish welfare in a changing world: New developments and current challenges

Journal of Fish Biology, EarlyView.
Abstract The welfare of non‐human animals is central to ethical discussions on animal use, with increasing attention to fish welfare across research, aquaria, aquaculture, and fisheries. This paper reviews current theoretical approaches to animal welfare and recent advances in defining and assessing fish welfare since the seminal paper by Huntingford ...
Sonia Rey Planellas, João L. Saraiva, Eliane Gonçalves‐de‐Freitas, Pablo Arechavala‐Lopez, Bernice Bovenkerk, Michael Breen, Steven J. Cooke, Martin Føre, Lene Northwood, Lars Helge Stien, Sunil Kadri, Chris Noble, Jonatan Nilsson, Fernando Rodriguez, Cosme Salas, Peter Sandøe, Hans van de Vis   +16 more
wiley   +1 more source

Expanding the Fish‐Brain Invitrome With the Senegalese Sole SsB‐1 Cell Line—A Versatile Model for Neurotropic Virus Research

Journal of Fish Diseases, EarlyView.
ABSTRACT Cell lines are essential tools for studying animal physiology and immunopathology, reducing the use of live animals and supporting the 3Rs principle of reduction, refinement, and replacement. The Senegalese sole (Solea senegalensis), a relevant species for Spanish aquaculture diversification, lacks established in vitro models. We developed SsB‐
Yulema Valero, Alberto Cuesta
wiley   +1 more source

Learnings, Challenges and Processes of Prioritizing Initial Programme Theories on Contextually Appropriate Nurse Staffing Models With a Multinational Team: A Realist Methodology Case Example

Journal of Clinical Nursing, EarlyView.
ABSTRACT Aim To describe the processes, consensus‐building activities, learning and challenges of prioritizing initial programme theories on appropriate nurse staffing models across a multinational research team of academics, trainees and knowledge users from four countries.
Kaitlyn Tate, Andrew Booth, Gillian Harvey, Tony Ryan, Inge Wolbers, Pieterbas Lalleman, Candice Oster, Rachel Flynn, Tatiana Penconek, Matthias Hoben, Tim Schultz, Greta G. Cummings, on behalf of the ReSoNANCE (Realist Synthesis of Nursing in Australia Netherlands Canada and England) group   +12 more
wiley   +1 more source

Dynamic Capabilities as Drivers of Circular Business Models: Exploring Direct and Indirect Relationships

Journal of Product Innovation Management, EarlyView.
ABSTRACT Academic Summary Despite the urgent need for a circular economy, firms' transition from linear to circular business models (CBMs) remains slow. While previous research suggests that dynamic capabilities are the key drivers of this transition, it assumes a direct link, overlooking that these capabilities can facilitate change but do not ...
Jörn Block, Thomas Clauss, Matheus Franco, Timo Lemcke, Hubert Speth   +4 more
wiley   +1 more source

Feeding Laboratory Mice: Comparing a Standard Versus a Purified Diet – Marked Effects on Digestive Physiology

Journal of Animal Physiology and Animal Nutrition, EarlyView.
ABSTRACT Diet composition and processing have a major impact on its utilisation by the animal, as is known from farm and pet animal species. This includes effects on energy and nutrient digestibility, the intermediary metabolism, and the intestinal microbiome, with all the resulting impacts. For laboratory animals, data is scarce on influencing factors
L. F. Böswald, A. Zeyner, M. M. Santo, M. Wensch‐Dorendorf, A. Sünder, B. Popper, W. Siegert   +6 more
wiley   +1 more source

Metabolic Reprogramming and GM‐CSF Secretion in Areca Nut‐Activated Fibroblasts Drive Oral Precancer Progression

Oral Diseases, EarlyView.
ABSTRACT Objective Oral cancer, with a rising global incidence and poor prognosis, is associated with areca nut use in South and Southeast Asia. In this study, we addressed the effects of areca nut extract (ANE) on oral carcinogenesis by modulating fibroblast behavior in oral tissue.
Yen‐Yun Wang, Chang‐Wei Su, Chih‐Huang Tseng, Pang‐Yu Chen, Hieu D. H. Nguyen, Leong‐Perng Chan, Yuk‐Kwan Chen, Shih Sheng Jiang, Steven Lo, Shyng‐Shiou F. Yuan   +9 more
wiley   +1 more source