Results 151 to 160 of about 13,325 (255)

The Innovation Centre 3Rs (IC-3Rs) in Belgium

, 2022
T. Vanhaecke, M. Van Mulders, M. Rodrigues, B. Mertens, J. De Kock, V. Rogiers   +5 more
core  

Targeting Temozolomide‐Resistant Glioblastoma: Therapeutic Potential of Neuronal Nitric Oxide Synthase Inhibitor

Cancer Medicine, Volume 15, Issue 7, July 2026.
ABSTRACT Background and Purpose The treatment of glioblastoma remains a major clinical challenge, largely due to intrinsic and acquired resistance to Temozolomide (TMZ). We aim to advance a novel therapeutic approach to overcome TMZ resistance in human glioblastoma by using the neuronal nitric oxide synthase inhibitor BA‐101 as both a monotherapy and ...
Mallikarjuna Nimgampalle, Shashank Kumar Ojha, Maryam Kartawy, Michelle Feivelson, Haitham Amal   +4 more
wiley   +1 more source

Artificial Intelligence for Regulatory Evidence: A Systematic Document Analysis of European Medicines Agency Regulatory Advice and Public Reports

Clinical Pharmacology &Therapeutics, Volume 120, Issue 1, Page 224-235, July 2026.
Artificial intelligence (AI) is receiving increasing attention across the entire lifecycle of medicines, from early development to postauthorization use. While various AI tools have been developed in commercial and academic settings, the extent of their use in regulatory contexts within the European Union remains unknown.
Lucina‐May Nollen, Gerard J.P. van Westen, Gabriel Westman, Anna M.G. Pasmooij   +3 more
wiley   +1 more source

Discovery and Structural Characterization of a Highly Protective Neutralizing Antibody Targeting the Mpox Virus A35R Protein

MedComm, Volume 7, Issue 7, July 2026.
High‐affinity monoclonal antibodies (mAbs) targeting the MPXV EEV protein A35R were rapidly isolated using mRNA‐LNP vaccination and the Beacon single‐cell sorting Optofluidic platform, followed by functional profiling. One mAb, 17H1, potently neutralized authentic MPXV and conferred complete protection in vivo.
Shimeng Bai, Shuo Song, Xin Wang, Yuxin Xiao, Yun Long, Fenfang Wu, Fuxiang Wang, Zhongyi Fan, Jianqing Xu, Maozhou He, Hongzhou Lu   +10 more
wiley   +1 more source

SCRAPZON - With 3R’s

International Journal for Research in Applied Science and Engineering Technology
This paper presents New Trend is Scrap consists of recyclable and leftover stuff from the product manufacturing and consumption, such as parts of vehicles, building supplies, newspapers, notebooks, etc. Our vision to divert recyclables from India’s unsanitary landfills.
openaire   +1 more source

Sorafenib Restores Pentose Phosphate Pathway‐Related Redox Homeostasis via the c‐Raf/HSP90/G6PD Axis in Hepatic Ischemia‐Reperfusion Injury

MedComm, Volume 7, Issue 7, July 2026.
Proposed mechanism of middle‐dose sorafenib modulates redox homeostasis via c‐Raf/HSP90/G6PD axis to attenuate hepatic IRI. This study demonstrates that middle‐dose sorafenib mitigates hepatic IRI through the c‐Raf/HSP90/G6PD axis to enhance pentose phosphate pathway‐mediated antioxidant defense and redox homeostasis, thereby alleviating inflammatory ...
Fengqiang Gao, Libin Dong, Yawen Tan, Zhen Zhang, Shengjun Xu, Zijian Lou, Yichao Wu, Siyu Chen, Li Zhuang, Zhengxing Lian, Shusen Zheng, Nasha Qiu, Kai Wang, Xiao Xu   +13 more
wiley   +1 more source

EGFR‐Targeting IgG1 Antibody Enhances NK Cell‐Mediated Tumor Killing in KRAS‐Mutant Pancreatic Cancer

MedComm, Volume 7, Issue 7, July 2026.
In KRAS‐mutant pancreatic cancer, persistent downstream signaling can limit the efficacy of EGFR‐targeting mAbs. However, the addition of NK cells enables nimotuzumab to effectively direct a potent antitumor response via antibody‐dependent cellular cytotoxicity (ADCC), overcoming this resistance mechanism.
Ruoxi Xiao, Xiaoxiao Li, Ping Li, Junjin Wang, Xiaoyuan Sun, Chenyang Zhao, Zimin Liu, Ruining Gong, Minghan Ren, Ke Lei, He Ren   +10 more
wiley   +1 more source

Low‐frequency electroacupuncture attenuates insulin resistance in a rat model of diet‐induced maternal obesity

Pregnancy, Volume 2, Issue 4, July 2026.
Abstract Introduction Maternal obesity is highly prevalent worldwide, conferring elevated risks of maternal/fetal complications and adult‐onset disease in offspring. Obesity and pregnancy are both states of insulin resistance. Percutaneous electrical stimulation of skeletal muscle, better known as electroacupuncture (EA), mitigates insulin resistance ...
David J. Carr, Elizabeth Kelley, Morgan Sekhon, Megan Kawasaki, Keara McElroy‐Yaggy, R. Chris Skinner, Paul D. Taylor, Anna L. David, Elisabet Stener‐Victorin, Thomas L. Jetton   +9 more
wiley   +1 more source

The amino terminal domain of the human α7 nicotinic acetylcholine receptor subunit leads to the functional expression of human/insect receptors

British Journal of Pharmacology, Volume 183, Issue 13, Page 3517-3537, July 2026.
Human α7 receptors have been characterised in terms of pharmacological properties. Insertion of the N‐terminal domain of the human α7 subunit leads to honeybee and cockroach chimeric receptors activated by ACh and inhibited by α‐Bgt. Insertion of the human cys‐loop leads to cockroach chimeric receptors modulated by PNU.
Alison Cartereau, Chloé Veront, Alexandra Cremades, Priscilla Martin, Remi Gojard, Nicolas Galland, Emiliane Taillebois, Dieudonnée Togbé, Jean‐Yves Le Questel, Steeve H. Thany   +9 more
wiley   +1 more source

Preclinical and Virtual Models of Mucosal Melanoma: Bridging Translational Gaps in a Rare and Lethal Cancer

Pigment Cell &Melanoma Research, Volume 39, Issue 4, July 2026.
Integrated physical and virtual modeling provides a scalable framework to overcome sample scarcity, recapitulate mucosal melanoma biology, and accelerate translational discovery toward precision medicine. ABSTRACT Mucosal melanoma (MM) is a rare and lethal subtype of melanoma, disproportionately affecting Asian populations and exhibiting distinct ...
Xiangjie Jin, Yuhan Zhang, Yuantai Zhu, Zhiyuan Zhang, Chaoji Shi   +4 more
wiley   +1 more source