Results 121 to 130 of about 9,574 (212)

Deficiency of Tissue Nonspecific Alkaline Phosphatase Dysregulates Microglial Morphology and Function in a Mouse Model of Infantile Hypophosphatasia

Journal of Neurochemistry, Volume 170, Issue 3, March 2026.
Using male and female tissue‐nonspecific alkaline phosphatase (TNAP) knockout (KO) and wild type (WT) mice, we show TNAP loss impairs growth and sensorimotor function and induces marked microglial morphological changes (enlarged soma, retracted processes).
Kareem Elaswad, Yara Mashal, Iyah Nasser, Linna Almhanaa, Chloe Grabowski, Zhi Zhang   +5 more
wiley   +1 more source

SCRAPZON - With 3R’s

International Journal for Research in Applied Science and Engineering Technology
This paper presents New Trend is Scrap consists of recyclable and leftover stuff from the product manufacturing and consumption, such as parts of vehicles, building supplies, newspapers, notebooks, etc. Our vision to divert recyclables from India’s unsanitary landfills.
openaire   +1 more source

LDL Cholesterol Modulates Astrocyte Metabolism, Lipid Handling, and Morphology: Evidence From In Vitro and In Vivo Models

Journal of Neurochemistry, Volume 170, Issue 3, March 2026.
In vitro, low‐density lipoprotein cholesterol (LDL cholesterol) promotes the accumulation of lipid derivatives in astrocytes. Additionally, LDL cholesterol exposure causes a decrease in the expression of low‐density lipoprotein receptor (LDLr), 3‐hydroxy‐3‐methylglutaryl‐CoA reductase (HMGCR), and sterol regulatory element‐binding transcription factor ...
Gabriela Joras Baumart, Matheus Scarpatto Rodrigues, Juliete Nathali Sholl, Arieli Cruz de Sousa, Augusto Ferreira Weber, Lílian Corrêa Costa‐Beber, Hémelin Resende Farias, Mariana Viana Costa, Ariadni Mesquita Peres, Pedro Rocha de Camargo, Fernanda Telles Fróes, Rachel Krolow Bast, Andreza Fabro de Bem, Fabrício Figueiró, Fátima T. C. R. Guma, Jade de Oliveira   +15 more
wiley   +1 more source

Correspondence to the Letter to the Editor entitled "Critical evaluation of factorial experimental designs and temporal confounding in comparative analysis of dietary versus parenteral iron administration effects on cortical and trabecular bone parameters" by Zaheer M.H. et al. [PDF]

JBMR Plus
Spasić MV, Mayer B.
europepmc   +1 more source

The 3Rs of Animal Research [PDF]

eBioMedicine, 2022
openaire   +2 more sources

Human Derived Exosome Injections (ASCE+ vs. CELLEXOSOME) Enhance Collagen Remodeling and Angiogenesis in Intact Skin: A Comparative Experimental Study

Journal of Cosmetic Dermatology, Volume 25, Issue 3, March 2026.
ABSTRACT Background Exosomes derived from human cells have emerged as promising biological agents for enhancing skin quality through stimulation of collagen remodeling and angiogenesis. While their role in wound healing is well established, their effects on intact, non‐injured skin remain insufficiently investigated.
Noury Adel, Jack Kolenda, Francisco Llano, Jesper Thulesen, Francisco Hernandez Gomez Crespo, Yundun Shen, Youn Kyong Jo, Gabriela Yareli Zavala Resendiz, Diego Ivan Briseno Torres, Jesus Alejandro Lopez‐Lara, Ida Vega Thulesen   +10 more
wiley   +1 more source

Building a sustainable framework for laboratory animal welfare and ethics education: challenges and reform strategies. [PDF]

Front Vet Sci
Zhang J, Zhang L.
europepmc   +1 more source

Comparison of Human and Canine P‐Glycoprotein Substrates at R, P, and H Binding Sites

Journal of Veterinary Pharmacology and Therapeutics, Volume 49, Issue 2, Page 120-130, March 2026.
ABSTRACT P‐glycoprotein (P‐gp) greatly impacts substrate drug disposition, so much so that regulatory agencies recommend ascertaining the P‐gp status of active pharmaceutical ingredients (APIs) intended for human use. Arguably, the P‐gp status of drugs intended for canine patients is equally, if not more, important.
Neal S. Burke, Katrina L. Mealey
wiley   +1 more source

A quality framework for cryopreserved rodent disease models: INFRAFRONTIER quality principles in EMMA archiving and distribution. [PDF]

Mamm Genome
Ehlich H, Blease A, Biju R, Gustems M, Song F, Fessele S, Massimi M, Bozonelos K, Ntafis V, Hiltunen AE, Marschall S, Stoeger C, Khorshidi Z, Ziadi A, Jambou K, Armagno A, Scavizzi F, Raspa M, Fernandez J, Del Hierro MJ, Ayadi A, Pensavalle J, Prevost G, Dufková L, Krupkova M, Nickl P, Krimpenfort P, van de Ven M, Jonkers J, Valera Vázquez G, Raess M, Beckers J, Moles A, Dahlhoff M, Montoliu L, Hérault Y, Hinttala R, Kontoyiannis DL, Sedlacek R, Hrabě de Angelis M, Boersma AA, Matteoni R.   +41 more
europepmc   +1 more source

Antenatal betamethasone impairs markers of cardiac development and function in near‐term lambs

Experimental Physiology, Volume 111, Issue 3, Page 988-1007, 1 March 2026.
Abstract figure Summary of key molecular differences in the left ventricle of near‐term lambs exposed to antenatal betamethasone, compared to saline. Pregnant ewes received two doses of either saline (Saline) or betamethasone (Betamethasone, intramuscular, 11.4 mg) given 24 h apart, before delivery at 140 days of gestation (dG, term = 150 dG).
Reza Amanollahi, Ashley S. Meakin, Stacey L. Holman, Vicki L. Clifton, Kent L. Thornburg, Michael D. Wiese, Kathryn L. Gatford, Mitchell C. Lock, Janna L. Morrison   +8 more
wiley   +1 more source