Results 81 to 90 of about 14,239 (267)

Restoration of Degraded Tropical Peatland in Indonesia: A Review

Land, 2021
Tropical peatlands are fragile ecosystems with an important role in conserving biodiversity, water quality and availability, preventing floods, soil intrusion, erosion and sedimentation, and providing a livelihood for people.
Tri Wira Yuwati, Dony Rachmanadi, Pratiwi, Maman Turjaman, Yonky Indrajaya, Hunggul Yudono Setio Hadi Nugroho, Muhammad Abdul Qirom, Budi Hadi Narendra, Bondan Winarno, Sri Lestari, Purwanto Budi Santosa, Rahardyan Nugroho Adi, Endang Savitri, Pamungkas Buana Putra, Reni Setyo Wahyuningtyas, Retno Prayudyaningsih, Wawan Halwany, Besri Nasrul, Bastoni, Daniel Mendham   +19 more
doaj   +1 more source

Big data and its impact on the 3Rs: a home cage monitoring oriented review

Frontiers Big Data
Undisturbed home cage recording of mouse activity and behavior has received increasing attention in recent years. In parallel, several technologies have been developed in a bid to automate data collection and interpretation.
S. Fuochi, M. Rigamonti, Eoin C. O’Connor, P. Girolamo, Livia D'Angelo   +4 more
semanticscholar   +1 more source

Membrane Fusion‐Mediated Cytosolic Delivery of Threose Nucleic Acids via Homotypic Nanoparticles Overcomes Drug Resistance in Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
This study introduces a biomimetic “nanofusion” platform that integrates the biostability of threose nucleic acids (TNA) with homotypic cell‐membrane cloaking to combat drug‐resistant TNBC. By leveraging a non‐canonical membrane‐fusion pathway for direct cytosolic delivery, the platform bypasses endosomal sequestration. To achieve potent AKT2 silencing
Wei Zheng, Tristan Juin Han Chang, Xinchao Li, Zhongqi Zhou, Chung Tin, Kenward Vong, Pierre Karam, Pik Kwan Lo   +7 more
wiley   +1 more source

Exploring resilience capacities with food innovators: a narrative approach

Global Sustainability, 2020
We interviewed grassroots food innovators in South Africa to explore the diverse ways in which their narratives expressed different capacities for resilience, such as dealing with surprise and shaping desirable change. We drew on key resilience themes of
Megan Lindow, Rika Preiser, Reinette Biggs   +2 more
doaj   +1 more source

Current Collector Engineering for New Efficient Bioresorbable Sodium‐Ion Batteries

Advanced Science, EarlyView.
A bioresorbable Na‐ion battery is proposed with Mo or Mg thin‐film current collectors for temporary implants. Mo‐based batteries exhibit superior electrochemical performance and stable cycling compared with Mg counterparts. XPS was used to investigate the Mo/Mg surface oxidation.
Bincy Lathakumary Vijayan, Eleonora Vandini, Vedi Kuyil Azhagan Muniraj, Hussien Hammoud, Oussama Jamai, Eve Djenizian, Marc Ramuz, Daniela Giuliani, Manuela Zavatti, Yann Tison, Hervé Martinez, Lucas Teolis, Esma Ismailova, David Moreau, Sébastien Maria, Thierry Djenizian   +15 more
wiley   +1 more source

Integrating 3Rs approaches in WHO guidelines for the batch release testing of biologicals: Reports from a series of NC3Rs stakeholder workshops.

Biologicals (Print)
A recent report presented to the WHO has highlighted significant opportunities for the implementation of 3Rs approaches (i.e. Replacement, Reduction and Refinement of animal tests) within their manuals, guidelines and recommendations for vaccines and ...
Elliot Lilley, Richard Isbrucker, Anthony Holmes   +2 more
semanticscholar   +1 more source

EphB1‐Mediated Transient Blood‐Brain Barrier Opening Facilitates a Ferritin‐Based Nanotherapeutic for Alzheimer's Disease

Advanced Science, EarlyView.
We constructed a brain‐targeted AFn‐DPZ nanodrug delivery system and identified EphB1 as its receptor on the blood‐brain barrier (BBB). This system facilitates drug transport across the BBB and thereby ameliorates cognitive impairment in Alzheimer's disease.
Shilin Wen, Jingjing Gao, Zhixian Wang, Qiumin Ma, Xiao‐Ling Xu, Jianer Chen   +5 more
wiley   +1 more source

Beyond Anthropocentrism: The Moral and Strategic Philosophy behind Russell and Burch’s 3Rs in Animal Experimentation

Science and Engineering Ethics
The 3Rs framework in animal experimentation– “replace, reduce, refine” – has been alleged to be expressive of anthropocentrism, the view that only humans are directly morally relevant.
Nico Dario Müller
semanticscholar   +1 more source

Black Hole Quencher‐Enhanced Plasmonic Photothermal Conversion

Advanced Science, EarlyView.
Researchers have developed a universal method to boost plasmonic photothermal conversion by attaching black hole quencher (BHQ) molecules to matched metal nanostructures. This hybrid approach increases efficiency by roughly threefold, reaching up to 69.1% in the near‐infrared‐II window.
Ruiyuan Zhang, Xinru Chen, Lin Shen, Jin Li   +3 more
wiley   +1 more source

Innovative Test Strip‐Based Colorimetric Sensors Integrated With Affinity Chromatography: Acetylcholinesterase Inhibitor Screening Breakthrough in Lycium Barbarum Leaves

Advanced Science, EarlyView.
Schematic diagrams illustrating the breakthrough in the screening of AChE inhibitors from LBL, and the research process of the pharmacodynamics of the NCP are presented. ABSTRACT Current Alzheimer's drugs exhibit limited effectiveness, highlighting the necessity for multi‐target treatments.
Yuping Sa, Hui Yuan, Jingui Ma, Zhigang Yang, Mei Wang, Weibiao Wang, Lingling Yang, Fen Ma, Weiman Zhang, Gidion Wilson Mening'oo, Guoning Chen, Xueqin Ma   +11 more
wiley   +1 more source