Results 71 to 80 of about 13,325 (255)

Membrane Fusion‐Mediated Cytosolic Delivery of Threose Nucleic Acids via Homotypic Nanoparticles Overcomes Drug Resistance in Triple‐Negative Breast Cancer

open access: yesAdvanced Science, EarlyView.
This study introduces a biomimetic “nanofusion” platform that integrates the biostability of threose nucleic acids (TNA) with homotypic cell‐membrane cloaking to combat drug‐resistant TNBC. By leveraging a non‐canonical membrane‐fusion pathway for direct cytosolic delivery, the platform bypasses endosomal sequestration. To achieve potent AKT2 silencing
Wei Zheng   +7 more
wiley   +1 more source

Restoration of Degraded Tropical Peatland in Indonesia: A Review

open access: yesLand, 2021
Tropical peatlands are fragile ecosystems with an important role in conserving biodiversity, water quality and availability, preventing floods, soil intrusion, erosion and sedimentation, and providing a livelihood for people.
Tri Wira Yuwati   +19 more
doaj   +1 more source

The 3Rs in Animal Welfare Bodies at Swedish Universities - Knowledge, Attitudes, Implementation [PDF]

open access: yes, 2021
The implementation of the 3Rs (replacement, reduction and refinement) is emphasized in EU Directive 2010/63.16 task of the animal welfare bodies (AWB) is to strengthen animal welfare and develop the 3Rs at research animal facilities. In 2016, we surveyed
Tornqvist, Elin   +3 more
core  

Current Collector Engineering for New Efficient Bioresorbable Sodium‐Ion Batteries

open access: yesAdvanced Science, EarlyView.
A bioresorbable Na‐ion battery is proposed with Mo or Mg thin‐film current collectors for temporary implants. Mo‐based batteries exhibit superior electrochemical performance and stable cycling compared with Mg counterparts. XPS was used to investigate the Mo/Mg surface oxidation.
Bincy Lathakumary Vijayan   +15 more
wiley   +1 more source

Exploring resilience capacities with food innovators: a narrative approach

open access: yesGlobal Sustainability, 2020
We interviewed grassroots food innovators in South Africa to explore the diverse ways in which their narratives expressed different capacities for resilience, such as dealing with surprise and shaping desirable change. We drew on key resilience themes of
Megan Lindow   +2 more
doaj   +1 more source

3Rs Principle and Legislative Decrees to Achieve High Standard of Animal Research

open access: yesAnimals, 2023
Animal experimentation is a vast ecosystem that tries to make different issues such as legislative, ethical and scientific coexist. Research in animal experimentation has made many strides thanks to the 3Rs principle and the attached legislative decrees,
Paolo Verderio   +5 more
doaj   +1 more source

Lung maneuvers of large amplitudes for probing physiological alterations in mouse models of asthma

open access: yesAnimal Models and Experimental Medicine, EarlyView.
Lung maneuvers of small amplitudes, such as the ones performed in oscillometry, are the current gold standard to probe lung mechanics in animals, but they are insensitive to detect baseline physiological alterations in mouse models of asthma. Herein, lung maneuvers of different amplitudes were compared in two mouse models of asthma.
Magali Boucher   +4 more
wiley   +1 more source

Animal research in the UK: Regulation, implementation, welfare and development of new approach methodologies

open access: yesAnimal Models and Experimental Medicine, EarlyView.
Scientific research with animals in the UK is regulated by the Animals (Scientific Procedures) Act 1986 with the National Centre for the Replacement, Refinement and Reduction of Animals in Research providing support for best practice and facilitating development of new approach methodologies.
Ewan St. John Smith   +6 more
wiley   +1 more source

Descriptive, comparative, and functional anatomy of the facial musculature in cattle (Bos taurus)

open access: yesThe Anatomical Record, EarlyView.
Abstract Facial expressions can provide insight into animal emotions and pain, but no standardized system for assessing the entire facial display in cattle (Bos taurus Linnaeus) exists. The Facial Action Coding System (FACS), originally developed for humans, identifies distinct facial movements based on mimetic muscles.
Maja Söderlind   +6 more
wiley   +1 more source

Operational Performance Implications of Circular Economy Implementation: An Empirical Exploration in the Manufacturing Sector

open access: yesBusiness Strategy and the Environment, EarlyView.
ABSTRACT The global manufacturing sector has increasingly adopted circular economy (CE) practices to address sustainability challenges and improve operational efficiency. This study explores the impact of five CE practices—reduce, reuse, remanufacture, recycle, and recover—on key operational performance dimensions: quality, speed, dependability ...
Jose Arturo Garza‐Reyes   +5 more
wiley   +1 more source

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