Results 71 to 80 of about 14,239 (267)
Maskless Fabrication of PLA‐Based Neural Arrays for CNS Recording and Stimulation
Advanced Materials Interfaces, EarlyView.Biodegradable neural interfaces enable bidirectional communication with the CNS. Through electrochemical characterization, ageing tests with impedance monitoring, and in vivo validation, we assess the performance of PLA‐based epicortical and spinal implants.
Anna De Salvo +14 more
wiley +1 more source
Advanced Science, EarlyView.This study presents a human Bone (and Bone Marrow)‐on‐a‐Chip model based on native human bone scaffolds and autologous cells. Dynamic perfusion and sequential cell seeding replicate the physiological bone remodeling process in vitro, enabling the long‐term culture of functional, mature bone marrow immune subpopulations.
Nina Stelzer +17 more
wiley +1 more source
60 Years of the 3Rs Symposium: Lessons Learned and the Road Ahead
ALTEXWhen The Principles of Humane Experimental Technique was published in 1959, authors William Russell and Rex Burch had a modest goal: to make researchers think about what they were doing in the laboratory – and to do it more humanely.
Michael Balls +14 more
semanticscholar +1 more source
Editorial: 3Rs approach (replace, reduce and refine animal models) to improve preclinical research
Frontiers in Physiology, 2022 “3Rs”means Replacement, Reduction, Refinement, a conception developed more than 50 years ago to improve welfare of animals used in research. This concept should be widely known by biomedical researchers, being a fundamental principle of investigations ...
L. Calvillo
semanticscholar +1 more source
Optimization of B Cell Responses in Human Immune System Mice Through Organoid Based Screening
Advanced Science, EarlyView.Human immune system (HIS) mice show limited B cell responses to immunization. Using HIS mouse spleen organoids, this study identifies cytokine combinations and innate immune signals that drive human B cell expansion, differentiation, and class‐switch. Applying these signals in vivo through temporal separation enables antigen‐specific IgG responses and ...
Haiqiao Sun +6 more
wiley +1 more source
The rise of Generative AI and possible effects on the economy
Economics and Business Review, 2023 The aim of the paper is to analyse the likely implications of Generative AI (GAI) on various aspects of business and the economy. Amid the rapid growth and maturing of Generative AI technologies such as Large Language Models (like ChatGPT by OpenAI) a ...
Orchard Tim, Tasiemski Leszek
doaj +1 more source
Biologicals (Print), 2022 The UK National Centre for the Replacement, Refinement, and Reduction of Animals in Research (NC3Rs) has been tasked by the World Health Organization (WHO) to review the extent to which animal-based testing methods are described in their manuals ...
Elliot Lilley +7 more
semanticscholar +1 more source
Advanced Science, EarlyView.This study utilized alloy micro‐galvanic coupling design to regulate the release of essential elements, thereby programming immune responses and promoting regeneration. The sacrificial anodic process of Zn‐0.8Mg reduced Zn2+ release compared to the “large cathode‐small anode” coupling of Zn‐0.8Fe.
Chaoyang Sun +14 more
wiley +1 more source
Implementation of the 3Rs Concept in Quality Control of Biologicals: Status and Prospects (Review)
Безопасность и риск фармакотерапииINTRODUCTION. Many countries are implementing an increasing number of alternatives to animal testing in the research, development, and quality control of medicines under the concept of 3Rs (replacement, reduction, and refinement).
L. A. Gaiderova +5 more
doaj +1 more source
Researchers' attitudes to the 3Rs-An upturned hierarchy? [PDF]
PLoS ONE, 2018 Animal use in biomedical research is generally justified by its potential benefits to the health of humans, or other animals, or the environment. However, ethical acceptability also requires scientists to limit harm to animals in their research. Training
Nuno Henrique Franco +2 more
doaj +1 more source