Results 61 to 70 of about 37,025 (306)
Alternatives to laboratory animals : ATLA, 2023 Animal experimentation has been integral to drug discovery and development and safety assessment for many years, since it provides insights into the mechanisms of drug efficacy and toxicity (e.g.
Nikita Narayan Naik +30 more
semanticscholar +1 more source
Molecular Oncology, EarlyView.Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova +25 more
wiley +1 more source
Static spherically symmetric solutions in mimetic gravity: rotation curves & wormholes
, 2016 In this work, we analyse static spherically symmetric solutions in the framework of mimetic gravity, an extension of general relativity where the conformal degree of freedom of gravity is isolated in a covariant fashion.
Myrzakulov, Ratbay +3 more
core +1 more source
An Engineered Living Material With Pro‐Angiogenic Activity Inducible by Near‐Infrared Light
Advanced Functional Materials, EarlyView.NIR‐responsive engineered living materials (ELMs) for controlled angiogenesis: Near‐infrared (800 nm) light activates engineered probiotic bacteria within alginate‐based living materials to secrete a blood vessel‐regenerating protein. The released protein promotes pro‐angiogenic effects in endothelial networks and chick chorioallantoic membranes.
Anwesha Chatterjee +4 more
wiley +1 more source
Frontiers in Marine Science, 2020 Endotoxin testing is a vital part of quality and safety control in pharmaceutical production. The primary method for this testing in North America and Europe is the limulus amebocyte lysate (LAL) test, a critical component of which is the blood of ...
Richard Gorman
doaj +1 more source
ASCA Observations of NLS1s: BH Mass Estimation from X-ray Variability and X-ray Spectra
, 2000 ASCA observations of Narrow-Line Seyfert 1 galaxies (NLS1s) are presented. We focus on the black hole size of the NLS1 sources by employing two independent methods for the mass estimation; one is using X-ray variability, the other is using a blackbody ...
Boller +4 more
core +2 more sources
Gravitational Effects in g Factor Measurements and High-Precision Spectroscopy: Limits of Einstein's Equivalence Principle [PDF]
, 2018 We study the interplay of general relativity, the equivalence principle, and high-precision experiments involving atomic transitions and g factor measurements.
Jentschura, Ulrich D.
core +3 more sources
Supporting the 3Rs worldwide: The 3Rs Database program
Biomedical Science and Engineering, 2021 Our 3Rs databases and informative websites facilitate the implementation of 3Rs methods.
openaire +2 more sources
Strategies to apply 3Rs in preclinical testing
Pharmacology Research & Perspectives, 2021 Animal experimentation has been fundamental in biological and biomedical research. To guarantee the maximum quality, efficacy and/or safety of products intended for the use in humans in vivo testing is necessary; however, for over 60 years, alternative ...
S. Gorzalczany, A. R. Rodriguez Basso
semanticscholar +1 more source
Advanced Healthcare Materials, EarlyView.Cerebral organoids are transforming brain research, yet the field remains fragmented. This comprehensive systematic review maps 738 studies published between 2014 and 2024 to uncover trends, gaps, and opportunities across neuroscience. Introducing OrganoidMap—an interactive, open‐access platform to explore and compare models—this work enables ...
Anna Wolfram +10 more
wiley +1 more source