Results 61 to 70 of about 14,239 (267)

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Advances in Animal Models and Cutting-Edge Research in Alternatives: Proceedings of the Third International Conference on 3Rs Research and Progress, Vishakhapatnam, 2022

Alternatives to laboratory animals : ATLA, 2023
Animal experimentation has been integral to drug discovery and development and safety assessment for many years, since it provides insights into the mechanisms of drug efficacy and toxicity (e.g.
Nikita Narayan Naik, Bharadwaja Vadloori, Suresh Poosala, P. Srivastava, S. Coecke, Adrian J. Smith, Aysha Akhtar, C. Roper, S. Radhakrishnan, Balaji Bhyravbhatla, M. Damle, V. K. Pulla, J. Hackethal, R. Horland, Albert P. Li, Falguni Pati, M. S. Singh, P. Occhetta, R. Bisht, P. Dandekar, Krishna Bhagavatula, D. Pajkrt, Michael Johnson, Tilo Weber, John Huang, Lisiena Hysenaj, Banerjee Mallar, Bhat Ramray, Santosh G Dixit, Shreekanth V Joshi, Mandar M. Kulkarni   +30 more
semanticscholar   +1 more source

Swiss 3R Competence Centre: Promoting the 3Rs implementation

Biomedical Science and Engineering, 2020
This contribution describes the history and activity of the Swiss 3R Competence Centre (3RCC), which has been founded in 2018. Among the most relevant activities, a call for project proposals on 3Rs was launched in 2018, with 47 proposals received for selection, followed by a call for nominations for a 3Rs award, which will be announced in Sept.
openaire   +2 more sources

A Novel Perfused Full‐Thickness Human Skin Microphysiological System for Modeling Injury, Regeneration, Tumor Pathophysiology, and Therapeutics Development

Advanced Healthcare Materials, EarlyView.
What if human skin could remain fully alive and functional outside the body for weeks? A New Alternative Method (NAM) based on a vascularized full‐thickness skin microphysiological system achieves precisely this, preserving native vasculature, resident immunity, and metabolic activity for up to three weeks, while faithfully recapitulating radiation ...
Yusuf Surucu, Hamid Malekzadeh, Alexa Rivera Del Rio Hernandez, Naresh Mahajan, Ethan Banks, Dayyan Ur Rahman, José A. Arellano, Katherine S. Yang, Alexey Altman, G.V. Naveen Kumar, Matthew L. Steinhauser, Jeffrey A. Gusenoff, J. Peter Rubin, Asim Ejaz   +13 more
wiley   +1 more source

A Lightweight, 3D‐Printable, Low‐Cost, “One‐Click” Dorsal Skin Window for High‐Quality Long‐Term Multimodal Subcutaneous Tumor Imaging

Advanced Healthcare Materials, EarlyView.
An innovative, lightweight 3D‐printed skinfold chamber system is presented for long‐term intravital imaging. This affordable, biocompatible platform simplifies surgical implantation and allows high‐resolution, multimodal visualization of the tumor microenvironment for up to four weeks.
Iván Cortés Domínguez, Xabier Morales Urteaga, Maider Esparza, Lucía Grande, Ainhoa Urbiola, Cristina Ederra, Tomas Muñoz Santoro, Beatrice Pinci, Alvaro Teijeira, Carlos Ortiz de Solórzano   +9 more
wiley   +1 more source

Hydrogel‐Based Airway‐on‐Tube With Perfusable Endothelial Lumen and Outward Epithelialization

Advanced Materials, EarlyView.
A hydrogel‐based airway‐on‐tube platform featuring a perfusable endothelial lumen and outward epithelialization is presented. The system supports primary human bronchial epithelial and lung microvascular endothelial coculture under air‐liquid interface conditions.
Ali Doryab, Jack F. Murphy, Michael Bartolf‐Kopp, Jenny C‐C Hsin, Alice Chernaik, Frank McCaughan, Yan Yan Shery Huang, Tomasz Jungst, Jürgen Groll   +8 more
wiley   +1 more source

Strategies to apply 3Rs in preclinical testing

Pharmacology Research & Perspectives, 2021
Animal experimentation has been fundamental in biological and biomedical research. To guarantee the maximum quality, efficacy and/or safety of products intended for the use in humans in vivo testing is necessary; however, for over 60 years, alternative ...
S. Gorzalczany, A. R. Rodriguez Basso
semanticscholar   +1 more source

Improving Guest and Owner Satisfaction through a Circular Economy: An Agritourism Case Study

Tourism and Hospitality
This study examines the role of agritourism in developing strategies to promote a circular economy by applying the 3Rs (reduce, reuse, and recycle) and improving guests’ satisfaction.
Paula Tavares de Carvalho, Ricardo Jorge Raimundo, José Dias Lopes   +2 more
doaj   +1 more source

Atlantic Horseshoe Crabs and Endotoxin Testing: Perspectives on Alternatives, Sustainable Methods, and the 3Rs (Replacement, Reduction, and Refinement)

Frontiers in Marine Science, 2020
Endotoxin testing is a vital part of quality and safety control in pharmaceutical production. The primary method for this testing in North America and Europe is the limulus amebocyte lysate (LAL) test, a critical component of which is the blood of ...
Richard Gorman
doaj   +1 more source

Culture of care in animal research – Expanding the 3Rs to include people

Laboratory Animals. Journal of the Laboratory Animal Science Association, 2022
Research on animals is essential for science and medical progress. While it is still necessary to conduct this research, it is essential to apply the highest standards in animal welfare, including animal husbandry and care.
F. Ferrara, B. Hiebl, P. Kunzmann, Florian Hutter, F. Afkham, Megan R. LaFollette, Christian Gruber   +6 more
semanticscholar   +1 more source