Results 61 to 70 of about 13,325 (255)

21st century skills = 3Rs + 4Cs

, 2012
There is widespread agreement amongst educators and the general public about the importance of the traditional fundamental building blocks that underpin learning. These skills are often referred to as the 3Rs - reading, writing and arithmetic.
Therese Keane (18924862)
core   +1 more source

The 3Rs in Animal Welfare Bodies at Swedish Universities - Knowledge, Attitudes, Implementation [Elektronisk resurs]

, 2021
The implementation of the 3Rs (replacement, reduction and refinement) is emphasized in EU Directive 2010/63.16 task of the animal welfare bodies (AWB) is to strengthen animal welfare and develop the 3Rs at research animal facilities. In 2016, we surveyed
Olsson, Ulf,, Sveriges lantbruksuniversitet., Berg, Lotta,, Lindsjö, Johan,   +3 more
core   +1 more source

Optimization of B Cell Responses in Human Immune System Mice Through Organoid Based Screening

Advanced Science, EarlyView.
Human immune system (HIS) mice show limited B cell responses to immunization. Using HIS mouse spleen organoids, this study identifies cytokine combinations and innate immune signals that drive human B cell expansion, differentiation, and class‐switch. Applying these signals in vivo through temporal separation enables antigen‐specific IgG responses and ...
Haiqiao Sun, He Li, Xu Zhu, Zijian Zhang, Deshan Ren, Shuai Ding, Yan Li   +6 more
wiley   +1 more source

Cephalopods in neuroscience: regulations, research and the 3Rs [PDF]

Invertebrate Neuroscience, 2014
Cephalopods have been utilised in neuroscience research for more than 100 years particularly because of their phenotypic plasticity, complex and centralised nervous system, tractability for studies of learning and cellular mechanisms of memory (e.g. long-term potentiation) and anatomical features facilitating physiological studies (e.g.
Fiorito G, Affuso A, Anderson DB, Basil J, Bonnaud L, Botta G, Cole A, D'ANGELO, LIVIA, DE GIROLAMO, PAOLO, Dennison N, Dickel L, DI COSMO, ANNA, Di Cristo C, Gestal C, Fonseca R, Grasso F, Kristiansen T, Kuba M, Maffucci F, Manciocco A, Mark FC, Melillo D, Osorio D, Palumbo A, Perkins K, Ponte G, Raspa M, Shashar N, Smith J, Smith D, Sykes A, Villanueva R, Tublitz N, Zullo L, Andrews P.   +34 more
openaire   +9 more sources

High‐Performance Prevascularized SHED‐Laden rGO@Hydrogel Achieves Optimized Diabetic Bone Defect Repair

Advanced Science, EarlyView.
A high‐performance 3D scaffold integrating rGO and SHEDs is developed to overcome impaired healing in diabetic bone defects. By driving extracellular matrix remodeling, rGO creates a pro‐angiogenic niche that significantly accelerates in vitro vascular network formation.
Can Zhang, Yiyuan Kang, Shulin Lai, Chunyi Wang, Guixin He, Kehui Jian, Suhan Yin, Xiner Tan, Xinru Zhou, Wenjing Liu, Fujian Zhao, Jia Liu, Longquan Shao   +12 more
wiley   +1 more source

Implementation of the 3Rs Concept in Quality Control of Biologicals: Status and Prospects (Review)

Безопасность и риск фармакотерапии
INTRODUCTION. Many countries are implementing an increasing number of alternatives to animal testing in the research, development, and quality control of medicines under the concept of 3Rs (replacement, reduction, and refinement).
L. A. Gaiderova, N. A. Alpatova, O. V. Golovinskaya, A. M. Guskov, E. K. Lipatova, M. N. Lavrova   +5 more
doaj   +1 more source

The 3Rs in Experimental Liver Disease

Animals, 2023
Patients with cirrhosis present multiple physiological and immunological alterations that play a very important role in the development of clinically relevant secondary complications to the disease. Experimentation in animal models is essential to understand the pathogenesis of human diseases and, considering the high prevalence of liver disease ...
Sebastian Martinez-Lopez, Enrique Angel-Gomis, Elisabet Sanchez-Ardid, Alberto Pastor-Campos, Joanna Picó, Isabel Gomez-Hurtado   +5 more
openaire   +5 more sources

The 3Rs of Cell Therapy [PDF]

, 2017
The 3Rs for a good education are “reading, 'riting, and 'rithmetic.” The basis for good health care solutions for the emergent field of cell therapy in the future will also involve 3Rs: regulation, reimbursement, and realization of value.
Caplan, AI, Reeve, B, Mason, C
core  

Micro‐Galvanic Coupling Programs the Therapeutic Zinc Ion Window to Reconfigure Immune Cascades for Pro‐Regenerative Bone Healing

Advanced Science, EarlyView.
This study utilized alloy micro‐galvanic coupling design to regulate the release of essential elements, thereby programming immune responses and promoting regeneration. The sacrificial anodic process of Zn‐0.8Mg reduced Zn2+ release compared to the “large cathode‐small anode” coupling of Zn‐0.8Fe.
Chaoyang Sun, Bo Jia, Jiahui Shi, Shuang Li, Guo Bao, Dong Bian, Kai Chen, Junlong Tan, Xuenan Gu, Yan Guan, Yu Qin, Xinhua Qu, Xiaogang Wang, Yufeng Zheng, Hongtao Yang   +14 more
wiley   +1 more source

The rise of Generative AI and possible effects on the economy

Economics and Business Review, 2023
The aim of the paper is to analyse the likely implications of Generative AI (GAI) on various aspects of business and the economy. Amid the rapid growth and maturing of Generative AI technologies such as Large Language Models (like ChatGPT by OpenAI) a ...
Orchard Tim, Tasiemski Leszek
doaj   +1 more source