Results 11 to 20 of about 24,212 (246)

The 4-Aminopyridine Model of Acute Seizures in vitro Elucidates Efficacy of New Antiepileptic Drugs [PDF]

Frontiers in Neuroscience, 2019
Up to date, preclinical screening for new antiepileptic substances is performed by a combination of different in vivo models of acute seizures, for which large numbers of animals are necessary.
Hanno Heuzeroth, Matthias Wawra, Pawel Fidzinski, Ramazan Dag, Martin Holtkamp   +4 more
doaj   +3 more sources

Sleep Deprivation‐Induced Anxiety Alleviated by Oral Administration of 4‐Aminopyridine in Male Mice [PDF]

Brain and Behavior
Purpose Insufficient sleep and insomnia are common issues associated with modern lifestyles that often contribute to the development of mental health disorders.
Ehsan Hosseini
doaj   +2 more sources

Phase IIB Randomized Trial on the Use of 4-Aminopyridine in Guillain-Barré Syndrome [PDF]

Archives of Rehabilitation Research and Clinical Translation, 2021
Objective: To determine the safety and efficacy of orally delivered 4-aminopyridine (4-AP) in persons with Guillain-Barré Syndrome (GBS) >6 months from initial diagnosis. Design: A randomized, double-blind, placebo-controlled, crossover study.
Jay M. Meythaler, JD, MD, Robert C. Brunner, MD, Jean Peduzzi, PhD   +2 more
doaj   +2 more sources

GAA-FGF14 disease: defining its frequency, molecular basis, and 4-aminopyridine response in a large downbeat nystagmus cohortResearch in context [PDF]

EBioMedicine
Summary: Background: GAA-FGF14 disease/spinocerebellar ataxia 27B is a recently described neurodegenerative disease caused by (GAA)≥250 expansions in the fibroblast growth factor 14 (FGF14) gene, but its phenotypic spectrum, pathogenic threshold, and ...
David Pellerin, Felix Heindl, Carlo Wilke, Matt C. Danzi, Andreas Traschütz, Catherine Ashton, Marie-Josée Dicaire, Alexanne Cuillerier, Giulia Del Gobbo, Kym M. Boycott, Jens Claassen, Dan Rujescu, Annette M. Hartmann, Stephan Zuchner, Bernard Brais, Michael Strupp, Matthis Synofzik   +16 more
doaj   +2 more sources

Radiochemical Synthesis and Evaluation of 3-[¹¹C]Methyl-4-aminopyridine in Rodents and Nonhuman Primates for Imaging Potassium Channels in the CNS. [PDF]

ACS Chem Neurosci, 2022
Sun Y, Guehl NJ, Zhou YP, Takahashi K, Belov V, Dhaynaut M, Moon SH, El Fakhri G, Normandin MD, Brugarolas P.   +9 more
europepmc   +3 more sources

New Solid Forms of Nitrofurantoin and 4-Aminopyridine Salt: Influence of Salt Hydration Level on Crystal Packing and Physicochemical Properties. [PDF]

Molecules, 2022
Boycov DE, Drozd KV, Manin AN, Churakov AV, Perlovich GL.   +4 more
europepmc   +3 more sources

157. Dietary Supplementation With 4-aminopyridine (4AP) to Promote Enhanced Wound Healing in Type II Diabetes [PDF]

Plast Reconstr Surg Glob Open
Nguyen A, Leckenby J.
europepmc   +2 more sources

PHOTOACTINIC IRRADIATION EFFECT ON REFRACTION INDICE OF ORGANIC CO-CRYSTALS BASED ON AMINOPYRIDINE SERIES [PDF]

Научно-технический вестник информационных технологий, механики и оптики, 2020
Subject of Research. The paper presents research of photoactinic radiation effect on refractive indice of organic nonlinear optical co-crystals: 2.6-diaminopyridine-4-nitrophenol and 4-aminopyridine-4-nitrophenol. Method. The research technique included
Kirill E. Zhevaikin, Maria I. Fokina, Alina S. Shirokova   +2 more
doaj   +1 more source

Corrigendum: Transdermal delivery of 4-aminopyridine accelerates motor functional recovery and improves nerve morphology following sciatic nerve crush injury in mice.

Neural Regen Res, 2021
europepmc   +2 more sources

Synthesis of 2-aminopyridine Lactones and Studies of Their Antioxidant, Antibacterial and Antifungal Properties

Chemistry Proceedings, 2021
In the present work, the synthesis and biological activities of substituted 2-aminopyridine δ-lactone derivatives were achieved. 4,6,6-trimethyl-2-oxo-5,6-dihydro-2H-pyran-3-carbonitrile was synthesised from 4-hydroxy-4-methylpentan-2-one, followed by ...
Fadila Salhi, Nawel Cheikh, Didier Villemin, Nathalie Bar   +3 more
doaj   +1 more source