Results 21 to 30 of about 24,212 (246)

4-Aminopyridine — A Review [PDF]

Anaesthesia and Intensive Care, 1982
4-aminopyridine is the first of the aminopyridines to be used in clinical practice. It blocks potassium channels and thereby increases acetylcholine, and possibly noradrenaline, release at nerve terminals. In man the drug has a significant action at the neuromuscular junction, but has little effect on the autonomic nervous system or muscle (smooth ...
N, Soni, P, Kam
openaire   +2 more sources

4-Aminopyridine Decreases MPTP-Induced Behavioral Disturbances in Animal Model of Parkinson’s Disease

International Clinical Neuroscience Journal, 2015
Background and purpose: Progressive degeneration of dopaminergic neurons in the midbrain is the main mechanism of Parkinson’s disease (PD). Although potassium channels affect neural activity and death in this area, little research has investigated the ...
Reza Taherian, Mehran Arab Ahmadi
doaj   +1 more source

The crystal structure of poly[bis(μ2−3−aminopyridine−4−carboxylato−κ2N:O)Zinc(II)], [Zn(C6H5N2O2)2]n

Zeitschrift für Kristallographie - New Crystal Structures, 2023
[Zn(C6H5N2O2)2${({\mathrm{C}}_{6}{\mathrm{H}}_{5}{\mathrm{N}}_{2}{\mathrm{O}}_{2})}_{2}$]n, orthorhombic, P212121 (no. 19), a = 7.6139(7) Å, b = 12.4890(13) Å, c = 13.9382(13) Å, V = 1325.4(2) Å3, Z = 4, Rgt(F) = 0.0391, wRref(F2) = 0.0710, T = 296 K.
Liu Fang-Fang, Ping Zhao-Yan, Zhou Wei-Wei, Zhao Wang   +3 more
doaj   +1 more source

Convulsant actions of 4-aminopyridine on the guinea-pig olfactory cortex slice [PDF]

, 1982
The effects of bath-applied 4-aminopyridine on neurones and extracellular potassium and calcium concentrations were recorded in slices of guinea-pig olfactory cortex. Neurones were orthodromically activated by stimulating the lateral olfactory tract.
Baranyi, Ben-Ari, Brismar, Brown, Buckle, Collins, Constanti, DiFrancesco, Dingemanse, Galvan, Galvan, Galvan, Gerrit Ten Bruggencate, Gilbey, Golenhofen, Halliwell, Heinemann, Jankowska, Jefferys, Kocsis, Lemeignan, Lipicky, Llinaś, Lundh, Martin Galvan, Matthews, McAfee, Mori, Neuman, Nicholson, Nicoll, Pelhate, Peter Grafe, Pichon, Scholfield, Scholfield, Schwartzkroin, Schwartzkroin, Sherratt, Shimahara, Spyker, Szente, Thesleff, Thompson, Ulbricht, von Haxthausen, Yanagisawa, Yeh   +47 more
core   +1 more source

4-Aminopyridinium azide 4-aminopyridine solvate

Acta Crystallographica Section E, 2010
In the title compound, C5H7N2+·N3−·C5H6N2, all N atoms of the azide anion are situated on a twofold rotational axis, so the 4-aminopyridinium cation and 4-aminopyridine molecule, being related by symmetry, occupy one position ...
Hui-Fen Qian, Wei Huang
doaj   +1 more source

Presynaptic actions of 4-Aminopyridine and γ-aminobutyric acid on rat sympathetic ganglia in vitro [PDF]

, 1980
Responses to bath-applications of 4-aminopyridine (4-AP) and -aminobutyric acid (GABA) were recorded intracellularly from neurones in the rat isolated superior cervical ganglion.
A Nistri, A Tokunaga, B Hue, B Katz, C Nicholson, CL Schauf, DA Brown, DA Brown, DA Brown, DA Brown, DA McAfee, DI Wallis, E Jankowska, E Kato, E Kato, G. ten Bruggencate, H Lundh, H Lundh, H Meves, IG Marshall, JE Heuser, JZ Yeh, JZ Yeh, K Golenhofen, M Lemeignan, M Lemeignan, M. Galvan, NG Bowery, P. Grafe, PR Adams, R Llinás, SY Chiu, T Brismar, T Yanagisawa, W Ulbricht, WC Bowman, WW Douglas   +36 more
core   +1 more source

Phosphoric acid doped polysulfone membranes with aminopyridine pendant groups and imidazole cross-links [PDF]

, 2015
Udel polysulfone based membranes with 4-aminopyridine pendant groups and cross-linking imidazole units are synthesized in a simple two step reaction. The ratio of 4-aminopyridine and imidazole is varied and the materials are extensively characterized ...
Cleemann, Lars Nilausen, Elsøe, Katrine, Han, Jonghee, Henkensmeier, Dirk, Hink, Steffen, Jang, Jong Hyun, Kim, Hyoung Juhn, Li, Qingfeng, Nam, Suk Woo   +8 more
core   +1 more source

Effect of ropivacaine combined with pancuronium on neuromuscular transmission and effectiveness of neostigmine and 4-aminopyridine for blockade reversal: experimental study

Revista Brasileira de Anestesiologia, 2015
BACKGROUND AND OBJECTIVES: The local anesthetic effects on neuromuscular junction and its influence on blockade produced by nondepolarizing neuromuscular blockers are still under-investigated; however, this interaction has been described in experimental ...
Angélica de Fátima Braga, Vanessa Henriques Carvalho, Franklin Sarmento Braga, Gloria Maria Braga Potério, Filipe Nadir Caparica Santos   +4 more
doaj   +3 more sources

Synthesis and Characterization of Palladium (II) Complexes With Some Pyridine Derivatives

Al-Mustansiriyah Journal of Pharmaceutical Sciences, 2008
Complexes of palladium (II) with pyridine derivatives in general formula: trans- [PdCl2L1 2], (where: L1 = 2- picoline, 3- picoline, 4- picoline); [pd L1 4](BF4) 2, (Where: L1=3-picoline, 4-picoline); trans- [PdCl2L2 2] and [pd L2 4] (BF4) 2, (Where: L2
M. J. Al-Jeboori, S. M. Lateef, A. R. A. AL-Shuaibi   +2 more
doaj   +1 more source

Redetermination of para-aminopyridine (fampridine, EL-970) at 150 K [PDF]

, 2005
The structure of fampridine (EL-970) or 4-aminopyridine, C₅H₆N₂, has been redetermined at 150 K. The room-temperature structure has been reported previously [Chao & Schempp (1977). Acta Cryst. B33, 1557-1564]. Pyramidalization at the amine N atom occurs
Anderson, Frankie P., Gallagher, John F., Kenny, Peter T.M., Lough, Alan J.   +3 more
core   +1 more source