Results 41 to 50 of about 24,212 (246)

Synthesis and enzymatic evaluation of 2- and 4-aminothiazole-based inhibitors of neuronal nitric oxide synthase

Beilstein Journal of Organic Chemistry, 2009
Highly potent and selective inhibitors of neuronal nitric oxide synthase (nNOS) possessing a 2-aminopyridine group were recently designed and synthesized in our laboratory and were shown to have significant in vivo efficacy.
Graham R. Lawton, Haitao Ji, Pavel Martásek, Linda J. Roman, Richard B. Silverman   +4 more
doaj   +1 more source

Crystal structure and Hirshfeld surface analysis of 4-aminopyridinium thiocyanate–4-aminopyridine (1/1)

Acta Crystallographica Section E: Crystallographic Communications, 2020
In the crystals of the title compound, C5H7N2+·CNS−·C5H6N2, the components are linked by three N—H...N and two N—H...S hydrogen bonds, resulting in two interpenetrating three-dimensional networks.
M. Renugadevi, A. Sinthiya, Kumaradhas Poomani, Suganya Suresh   +3 more
doaj   +1 more source

Physiological sharp wave-ripples and interictal events in vitro: What’s the difference? [PDF]

, 2014
Sharp wave-ripples and interictal events are physiological and pathological forms of transient high activity in the hippocampus with similar features.
Freund, Tamás, Gulyás, Attila, Karlócai, R. Mária, Kohus, Zsolt, Káli, Szabolcs, Máté, Zoltán, Szabó, Gábor, Ulbert, István   +7 more
core   +1 more source

Downbeat nystagmus: aetiology and comorbidity in 117 patients [PDF]

, 2008
Objectives: Downbeat nystagmus (DBN) is the most common form of acquired involuntary ocular oscillation overriding fixation. According to previous studies, the cause of DBN is unsolved in up to 44% of cases.
Brandt, Thomas, Glaser, Mirjam, Strupp, Michael, Wagner, Judith N.   +3 more
core   +1 more source

Chlorido(4-methylpyridin-2-amine-κN1)(2-{[(4-methylpyridin-2-yl)imino-κN]methyl}phenolato-κO)copper(II)

Acta Crystallographica Section E, 2012
In the title complex, [Cu(C13H11N2O)Cl(C6H8N2)], the CuII atom adopts a distorted tetrahedral geometry being coordinated by the phenolic O atom and the azomethine N atom of the Schiff base ligand N-salicylidene 2-aminopyridine, and by the 2-aminopyridine
Bussa Bhagyaraju, P. Sambasiva Rao, Toka Swu   +2 more
doaj   +1 more source

Functional Neurorehabilitation in Dogs with an Incomplete Recovery 3 Months following Intervertebral Disc Surgery: A Case Series

Animals, 2021
This case series study aimed to evaluate the safety, feasibility, and positive outcome of the neurorehabilitation multimodal protocol (NRMP) in 16 chronic post-surgical IVDD Hansen type I dogs, with OFS 0/DPP− (n = 9) and OFS 1/DPP+ (n = 7).
Ângela Martins, Débora Gouveia, Ana Cardoso, Carla Carvalho, Cátia Silva, Tiago Coelho, Óscar Gamboa, António Ferreira   +7 more
doaj   +1 more source

Facilitatory actions of guanidine on synaptic transmission in mammalian brain slices [PDF]

, 1979
Guanidine administration may be beneficial in the treatment of amyotrophic lateral sclerosis and related diseases; however, the actions of guanidine on the mammalian central nervous system have not been investigated.
Galvan, Martin, Grafe, Peter, Ten Bruggencate, Gerrit   +2 more
core   +1 more source

Thermally Drawn Multifunctional All‐Hydrogel Fibers for Anti‐Fibrotic and Multimodal Neural Interfaces

Advanced Materials, EarlyView.
Hydrogels demonstrate material properties that mimic the mechanical and chemical environments of biological tissues. Yet, they face challenges during their integration into 3D interfaces. By identifying a class of thermoplastic hydrogels, a strategy is developed to pattern hydrogels in thermally drawn fibers.
Changhoon Sung, Kum Seok Nam, Yeji Kim, Honey Kang, Kanghyeon Kim, Chanwoong Yoon, Somin Lee, Ain Chung, Jiheong Kang, Young‐Gyun Park, Alan Jung Park, Haider Butt, Hyunwoo Yuk, Seongjun Park   +13 more
wiley   +1 more source

4‐Aminopyridine promotes functional recovery and remyelination in acute peripheral nerve injury

EMBO Molecular Medicine, 2016
Traumatic peripheral nerve damage is a major medical problem without effective treatment options. In repurposing studies on 4‐aminopyridine (4‐AP), a potassium channel blocker that provides symptomatic relief in some chronic neurological afflictions, we ...
Kuang‐Ching Tseng, Haiyan Li, Andrew Clark, Leigh Sundem, Michael Zuscik, Mark Noble, John Elfar   +6 more
doaj   +1 more source

Two new mononuclear manganese(III) salen complexes

Acta Chimica Slovenica, 2014
Two new Mn(III)-salen complexes with 4-aminopyridine (4-apy) have been prepared and structurally characterized. [Mn(ac)(4-apy)(sal)], 1,exhibits mononuclear molecular structure with an octahedral environment around the Mn center.
Nina Lah, Sabina Grabner, Peter Bukovec
doaj   +1 more source