Results 71 to 80 of about 21,834 (203)

Late expression of FosB transcription factor in 4-aminopyridine-induced seizures in the rat cerebral cortex [PDF]

, 2008
In order to deliver services to citizens, public sector agencies of today offer various types of channels for interaction. In this article we aim to develop an understanding of the reciprocal relation between multi‑channel services and work prac tice. By
Bagosi, Andrea, Fejesné Bakos, Mónika, Krisztin-Péva, Beáta, Mihály, András   +3 more
core   +1 more source

Targeting Hsp90 with cemdomespib reduces seizure burden and alters disease course in preclinical epilepsy models

Epilepsia, EarlyView.
Abstract Objective Epilepsy is a chronic neurological disorder characterized by recurrent seizures and frequent cognitive and psychiatric comorbidities. Although current antiseizure medications provide symptomatic relief, they fail to prevent or modify epileptogenesis.
Yara Sheeni, Prince Kumar Singh, Sereen Sandouka, Taige Zhang, Alina Nemirovski, Aseel Saadi, Rhoda Olowe Taiwo, Matthew C. Walker, Tawfeeq Shekh‐Ahmad   +8 more
wiley   +1 more source

Inhibition of 4-aminopyridine-induced seizures in mice by a novel 3-substituted 1,4-benzodiazepine

Фармацевтичний журнал, 2019
Some of highly effective antiepileptic substances share the polymodal pharmacological action which determines the possibility of their use for treatment of pathogenetically similar diseases. Inhibitory mediator systems influence for example, suggests the
N. Ya. Golovenko, V. B. Larionov, A. S. Reder, I. P. Valivodz’   +3 more
doaj   +1 more source

A-Type KV Channels in Dorsal Root Ganglion Neurons: Diversity, Function, and Dysfunction [PDF]

, 2018
A-type voltage-gated potassium (Kv) channels are major regulators of neuronal excitability that have been mainly characterized in the central nervous system. By contrast, there is a paucity of knowledge about the molecular physiology of these Kv channels
Covarrubias, Manuel, Muqeem, Tanziyah, Ritter, David M., Zemel, Benjamin M.   +3 more
core   +1 more source

Molecular dissection of I(A) in cortical pyramidal neurons reveals three distinct components encoded by Kv4.2, Kv4.3, and Kv1.4 alpha-subunits [PDF]

, 2010
The rapidly activating and inactivating voltage-gated K(+) (Kv) current, I(A), is broadly expressed in neurons and is a key regulator of action potential repolarization, repetitive firing, backpropagation (into dendrites) of action potentials, and ...
Nerbonne, Jeanne M, Norris, Aaron J
core   +2 more sources

Interictal and seizure‐onset scalp electroencephalographic patterns in malformations of cortical development

Epilepsia, EarlyView.
Abstract Objective Malformations of cortical development (MCDs) are a frequent cause of drug‐resistant epilepsy and a common indication for resective epilepsy surgery. As magnetic resonance imaging (MRI) lacks sensitivity for subtle MCDs, supplemental diagnostic tools are needed.
Lubna Shakhatreh, Liz Edenberg P. Quiles, Zhibin Chen, Ofer M. Gonen, Saba Mohidat, Lyn Millist, Callum Hollis, Andrea Sundram, Piero Perucca, Terence J. O'Brien, Patrick Kwan   +10 more
wiley   +1 more source

4-Aminopyridine Decreases Progesterone Production by Porcine Granulosa Cells

Reproductive Biology and Endocrinology, 2003
Background Ion channels occur as large families of related genes with cell-specific expression patterns. Granulosa cells have been shown to express voltage-gated potassium channels from more than one family. The purpose of this study was to determine the
Mitchell Brianna M, Mason Diane E, von Stein Fred B, Ganta Suhasini, Li Yan, Freeman Lisa C   +5 more
doaj   +1 more source

Glutamate-mediated blood-brain barrier opening. implications for neuroprotection and drug delivery [PDF]

, 2016
The blood-brain barrier is a highly selective anatomical and functional interface allowing a unique environment for neuro-glia networks. Blood-brain barrier dysfunction is common in most brain disorders and is associated with disease course and delayed ...
CECCANTI , MARCO, Chassidim, Y, COLONNESE, Claudio, D'ELIA, ALESSANDRO, Fassler, M, Friedman, A., INGHILLERI, Maurizio, Nucciarelli, V, ONESTI, EMANUELA, Pell, Gs, Prager, O, Raccah, R, Roth, Y, SALVATI, Maurizio, SANTORO, Antonio, Shahar, H, Vazana, U, Veksler, R, Zangen, A   +18 more
core   +1 more source

Precision therapies for genetic epilepsies in 2025: Promises and pitfalls

Epilepsia Open, EarlyView.
Abstract By targeting the underlying etiology, precision therapies offer an exciting paradigm shift to improve the stagnant outcomes of drug‐resistant epilepsies, including developmental and epileptic encephalopathies. Unlike conventional antiseizure medications (ASMs) which only treat the symptoms (seizures) but have no effect on the underlying ...
Shuyu Wang, Emilio Perucca, Samuel F. Berkovic, Piero Perucca   +3 more
wiley   +1 more source

In vitro ictogenesis and parahippocampal networks in a rodent model of temporal lobe epilepsy

Neurobiology of Disease, 2010
Temporal lobe epilepsy (TLE) is a chronic epileptic disorder involving the hippocampal formation. Details on the interactions between the hippocampus proper and parahippocampal networks during ictogenesis remain, however, unclear.
G. Panuccio, M. D'Antuono, P. de Guzman, L. De Lannoy, G. Biagini, M. Avoli   +5 more
doaj   +1 more source