Results 111 to 120 of about 32,447,375 (296)
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
IGOR and Computer Assisted Innovation in Chemistry
CHIMIA, 1985 IGOR (Interactive Generation of Organic Reactions) is the first general-purpose, artificialintelligence-type computer program for generating graphic representations of unprecedented chemistry.
Johannes Bauer +3 more
doaj +1 more source
Guided block matching and 4-D transform domain filter projection denoising method for dynamic PET image reconstruction. [PDF]
EJNMMI Phys, 2023 Xin L, Zhuo W, Liu H, Xie T.
europepmc +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Tubular proteinuria and vitamin D deficiency in sickle cell disease [PDF]
, 2019 Kidney disease is a significant complication of sickle cell disease (SCD) with great public health concern, causing over 18% of total patient mortality. Proximal tubule (PT) dysfunction, including tubular proteinuria, is a common early symptom of kidney ...
Gliozzi, Megan
core
New Journal of Physics, 2013 The adsorption of benzene on metal surfaces is an important benchmark system for hybrid inorganic/organic interfaces. The reliable determination of the interface geometry and binding energy presents a significant challenge for both theory and experiment.
Wei Liu +6 more
doaj +1 more source
Attention-LSTM based prediction model for aircraft 4-D trajectory. [PDF]
Sci Rep, 2022 Jia P, Chen H, Zhang L, Han D.
europepmc +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
The Association Between Serum Vitamin D Concentration and Nueromuscular Function in Patients with Crohn's Disease [PDF]
, 2007 Serum vitamin D concentrations are not typically assessed in patients with Crohn's disease, even though neuromuscular complaints are one of the most common complaints observed.
Salacinski, Amanda J
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