Results 91 to 100 of about 26,058,575 (297)
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
4-D Micro-CT of the Mouse Heart
Molecular Imaging, 2005 Purpose: Demonstrate noninvasive imaging methods for in vivo characterization of cardiac structure and function in mice using a micro-CT system that provides high photon fluence rate and integrated motion control. Materials and Methods: Simultaneous cardiac- and respiratory-gated micro-CT was performed in C57BL/6 mice during constant intravenous ...
Cristian T. Badea +3 more
openaire +3 more sources
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
, 1898 Extract from speech of Charles D. Drake, chairman of Committee of Seventy, delivered at St.
Drake, Charles D.
core
, 2007 An alternative synthesis of 4-amino-3-hydroxy-4,5,6,6a-tetrahydro-3aH- cyclopenta[d]isoxazole-4-carboxylic acid, a conformationally constrained analogue of aspartic acid, is described.
G. Roda +11 more
core +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
, 1994 Two lactarane, sesquiterpenes, furoscrobiculin D and blennin D, previously isolated from the mushrooms Lactarius scrobiculatus and Lactarius blennius, respectively, have been submitted to conformational analysis by molecular mechanics. The results of the
VIDARI, GIOVANNI +5 more
core +1 more source
Клиническая онкогематология, 2018 Aim. To evaluate the efficacy of maintenance therapy in multiple myeloma (MM) patients after autologous hematopoietic stem cell transplantation (auto-HSCT) based on the results of MRI of bone marrow. Materials & Methods.
Maksim Valer’evich Solov’ev +6 more
doaj +1 more source
4-D Generative Model for PET/MRI Reconstruction [PDF]
, 2011 We introduce a 4-dimensional joint generative probabilistic model for estimation of activity in a PET/MRI imaging system. The model is based on a mixture of Gaussians, relating time dependent activity and MRI image intensity to a hidden static variable, allowing one to estimate jointly activity, the parameters that capture the interdependence of the ...
Stefano Pedemonte +4 more
openaire +2 more sources
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source