Results 81 to 90 of about 26,058,575 (297)

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

MEDIATION OF CHEMOTHERAPY-INDUCED APOPTOSIS BY THE LYSOSOMAL PROTEASE CATHEPSIN D [PDF]

, 2005
One of the most common hallmarks of cancer is dysregulation of cellular apoptotic processes. A comprehensive knowledge of the underlying mechanisms of the apoptotic machinery is vital for the identification of new drug targets and the development of ...
Emert-Sedlak, Lori A
core  

Determination of the Minimal Residual Disease Threshold in Acute Myeloid Leukemia Treated with ‘ОМЛ-17’ and ‘mОМЛ-17’ Regimens

Клиническая онкогематология
BACKGROUND. Minimal residual disease (MRD) refers to the tumor cells detected in complete remission patients by highly sensitive methods (PCR and flow cytometry). Each treatment regimen requires the determination of MRD threshold, i.e., the leukemic cell
Irina Vladimirovna Galtseva, E. N. Parovichnikova, K. A. Nikiforova, Yu. O. Davydova, N. M. Kapranov, I. A. Lukianova, A. A. Ievleva, Yu. A. Chabaeva, Z. T. Fidarova, L. A. Kuzmina, V. V. Troitskaya, T. V. Gaponova, S. M. Kulikov   +12 more
doaj   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Willis D. Johnson photo album, page 4

, 1940
Scan of page 4 from Willis D. Johnson photo album showing scenes from a trip to Echo Park and Dinosaur National Monument, Colorado and ...

core  

Thrombotic and Hemorrhagic Complications in the Treatment of Acute Lymphoblastic Leukemia with L-Asparaginase

Клиническая онкогематология, 2018
The article provides a literature review on the use of the L-asparaginase (ASP) in acute lymphoblastic leukemia (ALL) and describes two clinical cases.
Gennadii Martinovich Galstyan, O. A. Polevodova, A. V. Bazhenov, V. V. Troitskaya, O. A. Gavrilina, D. G. Gitel’zon, A. E. Vasil’ev, E. N. Parovichnikova   +7 more
doaj   +1 more source

Intermediate Results of Prospective, Randomized, Comparative Study of NHL BFM-90 and СНОЕР Efficacy in Primary ALK-Positive Anaplastic Large-Cell Lymphoma

Клиническая онкогематология, 2020
Aim. To compare NHL BFM-90 and CHOEP efficacy in adult patients with ALK-positive anaplastic large-cell lymphoma (ALK+ ALCL). Materials & Methods. Within the period from June 2014 to December 2019 the prospective randomized comparative study at the ...
Liliya Gamilevna Gorenkova, S. K. Kravchenko, E. E. Klebanova, A. M. Kovrigina, K. A. Sychevskaya, E. G. Gemdzhian, E. S. Nesterova, Ya. K. Mangasarova, A. V. Misyurin, Yu. V. Sidorova, T. N. Obukhova   +10 more
doaj   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Response-Adapted Strategy in the Treatment of Primary Mediastinal Large B-Cell Lymphoma: Results of a Prospective Single-Center Clinical Trial

Клиническая онкогематология
BACKGROUND. Up to now, neither the optimal treatment regimen for primary mediastinal large B-cell lymphoma (PMBCL), nor poor/favorable prognostic factors for risk stratification at the disease onset have been found.
Yana Konstantinovna Mangasarova, R. R. Abdurashidova, A. U. Magomedova, O. V. Margolin, E. S. Nesterova, L. G. Gorenkova, M. O. Bagova, E. A. Fastova, D. S. Belkina, A. M. Kovrigina, N. G. Gabeeva, D. A. Koroleva, S. K. Kravchenko, Yu. A. Chabaeva, E. E. Zvonkov   +14 more
doaj   +1 more source