Results 191 to 200 of about 9,315,415 (239)

Pharmacologic therapies for hypertrophic cardiomyopathy: The past, the present, and the future. [PDF]

JRSM Cardiovasc Dis
Halațiu VB, Cozac DA, Scridon A.
europepmc   +1 more source

Potentially inappropriate medications for patients with heart failure: a nationwide retrospective study from 2012 to 2022. [PDF]

J Pharm Policy Pract
Sunaga T, Ishii S, Nagao M, Nakamura S, Iso Y, Ebato M.   +5 more
europepmc   +1 more source

Cooperative Aldehyde Chemistry Maps an Orthogonal Lysine Reactivity Landscape. [PDF]

J Am Chem Soc
Galindo AV, Sihag P, Talbott JM, Raj M.
europepmc   +1 more source

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Diversified Synthetic Pathway of 1, 4-Dihydropyridines: A Class of Pharmacologically Important Molecules

Mini-Reviews in Medicinal Chemistry, 2021
The current review discusses the different synthetic pathways for one of the most important and interesting heterocyclic ring systems, 1,4-dihydropyridine. This cyclic system depicts diverse pharmacological action on several receptors, channels, and enzymes. Dihydropyridine moiety plays an important role in several calcium-channel blockers. Moreover,
Shubham, Khot, Pratibha B, Auti, Samrat A, Khedkar   +2 more
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N‐alkylation of 1, 4‐dihydropyridine derivatives

Bulletin des Sociétés Chimiques Belges, 1973
AbstractA series of 1‐alkyl‐2, 6‐dimethyl‐3, 5‐diethoxycarbonyl‐4‐aryl‐1, 4‐dihydropyridines have been synthesised by the reaction of the corresponding 1, 4‐dihydro‐pyridines with consecutively sodium hydride and alkyl halides.
R. A. Dommisse, F. C. Alderweireldt
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1, 4‐Dihydropyridine mit Etacrynsäure‐Partialstruktur

Archiv der Pharmazie, 1992
AbstractAusgehend von dem Acetophenon 3 werden über die Nitrobenzyliden‐Verbindungen 4 und 5 die 1,4‐Dihydropyridine (DHP) 6 und 7 mit einem Dichlorphenoxyessigsäure‐Substituenten hergestellt. Die DHP werden zu den Pyridinen 8 und 9 oxidiert. Bei der Bestrahlung des DHP 6a entsteht die cyclische Hydroxamsäure 10.
Klaus Görlitzer, Wolfgang Düwel
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Synthesis of 2,3-dihydrobenzofuran-3-spiro-4′-dihydropyridines

Tetrahedron Letters, 1981
Abstract 2,3-Dihydrobenzofuran-3-spiro-4′-dihydropyridines are readily available via intramolecular addition of enolates to pyridinium ions.
Dwight D. Weller, Glenn R. Luellen
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1, 4-Dihydropyridines: A Class of Pharmacologically Important Molecules

Mini-Reviews in Medicinal Chemistry, 2014
The 1,4-dihydropyridines (DHPs), a class of drugs possess a wide variety of biological and pharmacological actions, have represented one of the most important groups of calcium-channel modulating agents and have experienced widespread use in the treatment of cardiovascular disease which include antihypertensive, antianginal, vasodilator and cardiac ...
Samrat A, Khedkar, Pratibha B, Auti
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Synthese et reaction de diacyl-1,4 alkyl-4 dihydropyridines

Tetrahedron, 1973
Resume L'action du zinc et des anhydrides acetique, propionique et butyrique sur des pyridines substituees en C-4 donne des diacyl-1,4 alkyl-4 dihydropyridines, qui peuvent egalement etre obtenues par reaction radicalaire. L'acetyl-1 methylene-4 methyl-5 dihydro-4,5 azepine 24 a ete preparee par solvolyse du tosylate 23 , derivant de la diacetyl-1,
P.M. Atlani, J.F. Biellmann, J. Moron
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ChemInform Abstract: SYNTHESIS OF 2,3‐DIHYDROBENZOFURAN‐3‐SPIRO‐4′‐DIHYDROPYRIDINES

Chemischer Informationsdienst, 1982
AbstractBei der Kondensation von Salicylaldehydmethylether (I) mit 2‐Acetyl‐furan (II) erhält man unter alkalischen Bedingungen das Diketon (III), das durch weitere Kondensation mit Hydroxylamin, anschließende Permanganatoxidation und Thermolyse über das Pyridin (IVa) und die Dicarbonsäure (IVb) zum Decarboxylierungsprodukt (IVc) führt.
D. D. WELLER, G. R. LUELLEN
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