Results 161 to 170 of about 12,760,006 (203)

Purification and properties of hog liver 4-hydroxyphenylpyruvate dioxygenase

Archives of Biochemistry and Biophysics, 1982
Abstract The purification of hog liver 4-hydroxyphenylpyruvate dioxygenase (EC 1.13.11.27), and the determination of some of its characteristics, are reported. The enzyme was purified 330-fold in 22% yield from an acetone powder extract by ammonium sulfate fractionation, chromatography twice using sulfopropyl Sephadex under carefully controlled pH ...
P A, Roche, T J, Moorehead, G A, Hamilton   +2 more
openaire   +2 more sources

Pyrazole–Isoindoline-1,3-dione Hybrid: A Promising Scaffold for 4-Hydroxyphenylpyruvate Dioxygenase Inhibitors

Journal of Agricultural and Food Chemistry, 2019
The discovery of 4-hydroxyphenylpyruvate dioxygenase (HPPD, EC 1.13.11.27) inhibitors has been an active area of research due to their great potential as herbicides for weed control. Starting from the binding mode of known inhibitors of HPPD, a series of
Yang Jing-Fang, Hong-Yan Lin, Wen-Chao Yang   +2 more
exaly   +2 more sources

Discovery of novel benzofuran scaffold as 4‐hydroxyphenylpyruvate dioxygenase inhibitors

Pest Management Science, 2020
AbstractBACKGROUND4‐Hydroxyphenylpyruvate dioxygenase (HPPD) plays an important role in addressing the issue of plant protection research. This study sheds new light on the differences in molecular scaffold from commercialized HPPD inhibitors.RESULTSThe compounds A1‐A18 and B1‐B27 were synthesized for in vitro and greenhouse experiments. The greenhouse
Hao Huang, Jian‐qiu Zhang, Jian‐min Liu, Man‐man Wang, Lei Shu, Yi‐le Yan, Xiao‐hang Zhan, Ping Wang, Xue‐ting Huan, Da‐yong Zhang   +9 more
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Identification of a novel 4-hydroxyphenylpyruvate dioxygenase from the soil metagenome

Biochemical and Biophysical Research Communications, 2008
4-Hydroxyphenylpyruvate dioxygenase (HPPD) is a Fe(II)-dependent, non-heme oxygenase that converts 4-hydroxyphenylpyruvate to homogentisate. Essential cofactors, such as plastoquinone and tocopherol, are produced by HPPD-dependent anabolic pathways in plants.
Chang-Muk, Lee, Yun-Soo, Yeo, Jung-Han, Lee, Soo-Jin, Kim, Jung-Bong, Kim, Nam Soo, Han, Bon-Sung, Koo, Sang-Hong, Yoon   +7 more
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Improving the herbicide resistance of 4-hydroxyphenylpyruvate dioxygenase SpHPPD by directed evolution

Enzyme and Microbial Technology, 2022
Topramezone, a highly efficient 4-hydroxyphenylpyruvate dioxygenase (HPPD)-inhibitor herbicide, is an ideal target for herbicide-resistant genetic engineering. However, there is still a lack of HPPD gene that is highly resistant to topramezone. In previous studies, we obtained a topramezone-resistant HPPD (SpHPPDm) gene from Sphingobium sp.
Haiyan, Wang, Bin, Liu, Peng, Lei, Jianchun, Zhu, Le, Chen, Qin, He, Jian, He   +6 more
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Design and Syntheses of Proherbicides Targeting 4-Hydroxyphenylpyruvate Dioxygenase

Journal of Agricultural and Food Chemistry
4-Hydroxyphenylpyruvate dioxygenase (HPPD, EC 1.13.11.27) is regarded as a crucial target in the domain of herbicide discovery. Herein, we adopted the proherbicides concept, based on the initially discovered lead compound II-aa. Our group has designed four derivatives by incorporating alkyl, carbonyl ester, sulfonyl ester, and phosphate ester fragments.
Bo He, Li-jun Chen, Yi-xuan Fu, Tian-zhu Zhang, Feng-xu Wu, Jin Dong, Liang-Kun Yu, Xian-Quan Wang, Hong-Yan Lin, Guang-Fu Yang   +9 more
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Purification and Characterization of 4-Hydroxyphenylpyruvate Dioxygenase from Maize

Pesticide Science, 1996
The proposed target enzyme for benzoylcyclohexanedione herbicides, 4-hydroxyphenylpyruvate dioxygenase (HPPD) was purified from etiolated maize seedlings with a purification factor of 105. Enzyme activity was measured by detection of carbon dioxide formed from radiolabelled substrate. The enzyme has a pH optimum of 7.3 and an apparent molecular mass of
Istvan Cs. Barta, Peter Böger
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Advances in Understanding the Toxicity of 4-Hydroxyphenylpyruvate Dioxygenase-Inhibiting Herbicides

Journal of Agricultural and Food Chemistry
4-Hydroxyphenylpyruvate dioxygenase inhibiting herbicides (HIHs) represent a recent class (HRAC group 27) of herbicides that offer many advantages, such as broad-spectrum activity, crop selectivity, and low resistance rates. However, emerging studies have highlighted the potential toxicity of HIHs in the environment.
Ferdinand Ndikuryayo, Xue-Yan Gong, Wen-Chao Yang   +2 more
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Mechanism and Mechanism-Based Inactivation of 4-Hydroxyphenylpyruvate Dioxygenase

Bioorganic Chemistry, 1994
Abstract Six substrate analogs of 4-hydroxyphenylpyruvate, specifically pentafluorophenylpyruvate, 4-hydroxytetrafluorophenylpyruvate,2-thienylpyruvate, 3-thienylpyruvate, thiophenol oxalate, and p -thiocresoloxalate were synthesized and their interactions with porcine liver 4-hydroxyphenylpyruvate dioxygenase investigated.
B.J.R. Forbes, G.A. Gordon
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4-Hydroxyphenylpyruvate Dioxygenase Inhibitors: From Molecular Design to Synthesis

Journal of Agricultural and Food Chemistry
Weed resistance is a critical issue in crop production. Among the known herbicides, 4-hydroxyphenylpyruvate dioxygenase (HPPD) inhibitors are crucial for addressing weed resistance. HPPD inhibitors constitute a pivotal aspect of contemporary crop protection strategies.
Tengfei Ma, Shuang Gao, Li-Xia Zhao, Fei Ye, Ying Fu   +4 more
openaire   +2 more sources