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Effects of 4-nitroquinoline 1-oxide on the DNA-protein complex
Comparative Biochemistry and Physiology Part B: Comparative Biochemistry, 1986The effects of 4-nitroquinoline 1-oxide (4NQO), a well known carcinogenic compound, on the DNA-protein complex and DNA Folding Proteins were investigated. FM3A cells were treated with 10(-6) M or 10(-5) M 4NQO for 30 min. Treatment with the 10(-6) M concentration was confirmed to cause the sedimentation of the DNA-protein complex to become slower.
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Caffeine inhibits cell transformation by 4-nitroquinoline-1-oxide
Nature, 1975SOMATIC mutation has been considered a likely initiating step in chemical carcinogenesis1–3, chiefly because of the close correlation between the mutagenic and carcinogenic activity of various chemicals4–6. Study of cells from patients with disease predisposing to a high incidence of cancer, such as xeroderma pigmentosum and Fanconi's anaemia, has ...
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Reactions of 4-Nitroquinoline 1-Oxide with Aluminum Chloride
Russian Journal of Organic Chemistry, 20014-Nitroquinoline 1-oxide reacts with aluminum chloride to give 4-chloroquinoline 1-oxide. Aluminum chloride with 4-nitroquinoline 1-oxide forms a molecular complex in which it acts as electron acceptor and effective nucleophilic reagent (a source of chloride ions).
V. P. Andreev, Ya. P. Nizhnik
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Immortalization of normal human fibroblasts by treatment with 4‐nitroquinoline 1‐oxide
International Journal of Cancer, 1993AbstractNormal human fibroblasts (the OUMS‐24 strain), derived from a 6‐week‐old human embryo, were transformed (into the OUMS‐24F line) and immortalized by repeated treatments (59 times) with 4‐nitroquinoline 1‐oxide (4NQO). Treatment began during primary culture and ended at the 51st population doubling level (PDL).
L, Bai +4 more
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Persistence of 4-nitroquinoline-1-oxide induced lesions in human lymphocytes
Mutation Research/DNA Repair, 1996Liquid holding (LH) recovery was matched with three-way differential staining (TWD) to assess the reduction of damage induced in DNA following treatment with 4-nitroquinoline-1-oxide (4NQO) in resting (GO) lymphocytes. Human peripheral lymphocytes (HPL) from three donors were used to evaluate lesion persistence and individual repair capacity.
Ponzanelli I +2 more
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4-Nitroquinoline-1-Oxide: Factors determining its mutagenicity in bacteria
Mutation Research/Genetic Toxicology, 1981In bacteria, 4-nitroquinoline-1-oxide (NQO) causes primarily mutations of the base-substitution type although frameshift mutations are also induced. The adducts formed are presumably recognized by error-prone DNA repair enzymes as evidenced by the much greater activity in plasmid pKM101-bearing tester strains.
E C, McCoy +3 more
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Lack of effect of 4-nitroquinoline 1-oxide on cellular NAD levels
Mutation Research Letters, 1984Human KB cells were treated with doses of 4-nitroquinoline 1-oxide (4NQO) or dimethyl sulfate (DMS) that produced equal numbers of DNA-strand breaks when measured by velocity sedimentation analysis in an alkaline sucrose gradient. The DMS treatment also caused a profound and sustained lowering of cellular NAD content.
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High sensitivity of xeroderma pigmentosum cells to the carcinogen 4-nitroquinoline-1-oxide
Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 1972Jun-Ichi Furuyama +2 more
exaly
Mutagenic effect of a carcinogen, 4-nitroquinoline 1-oxide, in bacteriophage T4
Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 1970Hideya Endo
exaly