Results 191 to 200 of about 5,785 (211)

Greener Synthesis of some Bioactive 2, 5-Disubstituted-1, 3, 4-Oxadiazoles

Research Journal of Pharmacy and Technology, 2016
In the present paper, a series of substituted 1,3,4-oxadiazoles have been synthesized by three different methods i.e. conventional heating, microwave irradiation method 1 and microwave irradiation method 2. Conventional heating, microwave irradiation method 1 and microwave irradiation method 2 were compared in terms percent yield, reaction time ...
Parin K. Vora, Rakesh R. Somani, adhuri H. Jain, Sonali S. Parab, Pallavi M. Patil   +4 more
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Synthesis of arylethylene derivatives of 2, 5-diphenyl-1, 3, 4-oxadiazole

Chemistry of Heterocyclic Compounds, 1971
The synthesis of arylethylene derivatives of 2,5-diphenyl-1,3,4-oxadiazole by the Wittig reaction from 2-(p-bromomethylphenyl)-5-phenyl-1,3,4-oxadiazole and aromatic aldehydes is described. The compounds obtained fluoresce strongly on irradiation with UV light.
B. M. Krasovitskii, V. I. Grigor'eva
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Study on 1, 3, 4-Oxadiazole Derivatives as an Antibacterial and Antifungal Agents

2021
In the present investigation a new series of 1, 3, 4-oxadiazoles (3a-j) were synthesized by reacting INH (1) and substituted aromatic acids (2) in presence of POCl3. The new compounds were established on the basis of IR, 1H NMR and Mass spectral data.
B. C. Revanasiddappa, E. V. S. Subrahmanyam   +1 more
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Pharmacophore studies of 1, 3, 4-oxadiazole nucleus: Lead compounds as α-glucosidase inhibitors

Food and Chemical Toxicology, 2019
α-glucosidase inhibition is a rational approach in the effective management of type 2 diabetes. Several inhibitors of this enzyme class are in clinical use, but are riddled with efficacy, potency and safety challenges. For this reason, new effective α-glucosidase inhibitors are under investigation.
Haroon Khan, Muhammad Zafar, Seema Patel, SM Mukarrum Shah, Anupam Bishayee   +4 more
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Synthesis and biological evaluation of 1, 2, 4‐oxadiazole derivatives as novel GPR119 agonists

Chemical Biology & Drug Design, 2016
A series of 1, 2, 4‐oxadiazole derivatives have been designed and synthesized, and 25 compounds were evaluated their abilities by the assay of cAMP concentration in GPR119‐transfected HEK293T cells. All compounds showed acceptable agonistic effects on GPR119. Among these compounds, 4p exhibited the best agonistic effects with the EC50 of 20.6 nm, which
Suhong, Fu, Wei, Xiang, Jinying, Chen, Liang, Ma, Lijuan, Chen   +4 more
openaire   +2 more sources

Anti-inflammatory potentials of some novel Murrayanine containing 1, 3, 4-Oxadiazole derivatives

Asian Journal of Pharmacy and Technology, 2018
Based on the assumption that designing compounds with all the three features; a natural product, a synthetic component, and a functional Schiff’s base will surely lead to the development of more potent and safe analogs. The present research endeavors at designing a novel molecule from a previously reported starting material ( E )-2-((1-methoxy-9H ...
Debarshi Kar Mahapatra, Ruchi S. Shivhare, Vinod G. Ugale   +2 more
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Novel 1, 2, 4-oxadiazoles as potent and selective histamine H3 receptor antagonists

Bioorganic & Medicinal Chemistry Letters, 1996
Abstract Replacement of the isothiourea moiety of known histamine H 3 antagonists by certain 5-membered heteroaromatic systems can give compounds with an improved activity profile. One of these, 3-[(4-chlorophenyl)methyl]-5-[2-(1H-imidazol-4-yl)ethyl] 1,2,4-oxadiazole (GR175737) is a potent, selective, orally active and centally penetrating H 3 ...
J.W. Clitherow, P. Beswick, W.J. Irving, D.I.C. Scopes, J.C. Barnes, J. Clapham, J.D. Brown, D.J. Evans, A.G. Hayes   +8 more
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Design, Synthesis and Anti Cancer Evaluation of novel 1, 3, 4-oxadiazoles

Research Journal of Pharmacy and Technology
We designed and synthesized newer heterocyclic compounds with 1, 3, 4-thiadiazole, pyrimidine, and 1, 3, 4 -oxadiazole, with aimed to develop Histone Deacetylase (HDAC) inhibitors. The 1, 3, 4 - oxadiazole nucleus known for its diverse pharmacological properties and incorporating the thiadiazole and pyrimidine groups.
Meghna H. Seta, Monika T. Kyada
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ChemInform Abstract: Synthesis of Substituted 2‐(1′,3′,4′‐Oxadiazol‐2′‐yl)indoles.

Chemischer Informationsdienst, 1986
AbstractAseries of title compounds of type (IV), (VII) and (IX) is synthesized starting from the hydrazides (I).
K. H. SINNUR, S. SIDDAPPA, S. P. HIREMATH, M. G. PUROHIT   +3 more
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The preparation of 1, 3, 4-oxadiazoles

Chemistry of Heterocyclic Compounds, 1970
Ya. A. Levin, M. S. Skorobogatova
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