Results 271 to 280 of about 11,638,573 (298)

Design, Synthesis and Cytotoxicity of Novel Coumarin-1,2,3-triazole-1,2,4- Oxadiazole Hybrids as Potent Anti-breast Cancer Agents

Letters in Drug Design & Discovery, 2019
This work reports design, synthesis, and in vitro cytotoxicity of novel coumarin-1,2,3-triazole-1,2,4-oxadiazole hybrids against three breast cancer cell lines MCF-7, MDA-MB-231, and T-47D.
M. Mohammadi‐Khanaposhtani, Kiana Fahimi, Elahe Karimpour-razkenari, M. Safavi, M. Mahdavi, Mina Saeedi, T. Akbarzadeh   +6 more
semanticscholar   +1 more source

Novel 1, 2, 4-oxadiazoles as potent and selective histamine H3 receptor antagonists

Bioorganic & Medicinal Chemistry Letters, 1996
Abstract Replacement of the isothiourea moiety of known histamine H 3 antagonists by certain 5-membered heteroaromatic systems can give compounds with an improved activity profile. One of these, 3-[(4-chlorophenyl)methyl]-5-[2-(1H-imidazol-4-yl)ethyl] 1,2,4-oxadiazole (GR175737) is a potent, selective, orally active and centally penetrating H 3 ...
J.W. Clitherow, P. Beswick, W.J. Irving, D.I.C. Scopes, J.C. Barnes, J. Clapham, J.D. Brown, D.J. Evans, A.G. Hayes   +8 more
openaire   +1 more source

Design, Synthesis and Anti Cancer Evaluation of novel 1, 3, 4-oxadiazoles

Research Journal of Pharmacy and Technology
We designed and synthesized newer heterocyclic compounds with 1, 3, 4-thiadiazole, pyrimidine, and 1, 3, 4 -oxadiazole, with aimed to develop Histone Deacetylase (HDAC) inhibitors. The 1, 3, 4 - oxadiazole nucleus known for its diverse pharmacological properties and incorporating the thiadiazole and pyrimidine groups.
Meghna H. Seta, Monika T. Kyada
openaire   +1 more source

Synthesis, insecticidal activities and DFT study of pyrimidin-4-amine derivatives containing the 1,2,4-oxadiazole motif

Frontiers of Chemical Science and Engineering, 2021
Yong-Hui Wen, Long Cheng, Tianming Xu, Xing-Hai Liu, Ning‐Jie Wu   +4 more
semanticscholar   +1 more source

Molecular Structure, FT-IR Spectra, MEP and HOMO-LUMO Investigation of 2-(4-Fluorophenyl)-5-phenyl-1, 3,4-oxadiazole Using DFT Theory Calculations

, 2021
Sunil L. Dhonnar, N. V. Sadgir, V. A. Adole, B. Jagdale   +3 more
semanticscholar   +1 more source

ChemInform Abstract: Synthesis of Substituted 2‐(1′,3′,4′‐Oxadiazol‐2′‐yl)indoles.

Chemischer Informationsdienst, 1986
AbstractAseries of title compounds of type (IV), (VII) and (IX) is synthesized starting from the hydrazides (I).
K. H. SINNUR, S. SIDDAPPA, S. P. HIREMATH, M. G. PUROHIT   +3 more
openaire   +1 more source

Insights into the inhibition mechanism of 2,5-bis(4-pyridyl)-1,3,4-oxadiazole for carbon steel corrosion in hydrochloric acid pickling via experimental and computational approaches

Journal of Molecular Liquids, 2021
I. Nadi, M. Bouanis, F. Benhiba, K. Nohair, A. Nyassi, A. Zarrouk, C. Jama, F. Bentiss   +7 more
semanticscholar   +1 more source

The preparation of 1, 3, 4-oxadiazoles

Chemistry of Heterocyclic Compounds, 1970
Ya. A. Levin, M. S. Skorobogatova
openaire   +1 more source

1, 3, 4-Oxadiazole: A Versatile Compound With Potent Analgesic Activity

Oxadiazole is a heterocyclic ring with 5 members that has 1 oxygen atom, 2 nitrogen atoms, 2 double bonds, and 2 carbons. In furan, they are created by placing two methylene groups (=CH) for two nitrogen (-N=) atoms. The aromaticity was reduced by the substitution of these groups. There were four different isomer of oxadiazole that were identified: 1,3,
openaire   +1 more source

5‐(1‐Alkenyl)‐1, 3, 4‐oxadiazol‐2(3H)‐one

Helvetica Chimica Acta, 1974
Abstract3‐(2‐alkenoyl)‐thiocarbazic acid O‐methyl esters 1 are desulfurated by bromine and the unknown intermediates are transformed by alkali to 5‐(1‐alkenyl)‐1, 3, 4‐oxadiazol‐2(3H)‐ones (2). This type of oxadiazolone substitution is not realizable by the common ring closure of hydrazides with phosgene due to pyrazolidinone ring closure of ...
openaire   +1 more source