Results 51 to 60 of about 9,301,702 (224)

Review Article: The Impact of the Gut Microbiome on Ulcerative Colitis Pharmacotherapy

Alimentary Pharmacology &Therapeutics, EarlyView.
The gut microbiome modulates ulcerative colitis pharmacotherapy through microbial drug metabolism, immune regulation and altered drug bioavailability. Microbial composition influences response to aminosalicylates, corticosteroids, immunomodulators, biologics and small molecules, while microbiome‐targeted therapies show emerging promise.
Kate Collins, Srinivas Kamath, Rachel H. Davis, Samuel P. Costello, Robert V. Bryant, Alice S. Day, Paul Joyce   +6 more
wiley   +1 more source

Benzyl N-{2-[5-(4-chlorophenyl)-1,2,4-oxadiazol-3-yl]propan-2-yl}carbamate

Acta Crystallographica Section E, 2011
In the title 1,2,4-oxadiazole derivative, C19H18ClN3O3, the 1,2,4-oxadiazole ring makes dihedral angles of 12.83 (8) and 4.89 (8)°, respectively, with the benzyl and 4-chlorophenyl rings, while the dihedral angle between the ...
Hoong-Kun Fun, V. Sumangala, G. K. Nagaraja, Boja Poojary, Suchada Chantrapromma   +4 more
doaj   +1 more source

Planejamento, síntese e caracterização de derivados do 9,10-bis(5-fenil-1,3,4-oxadiazol-2-IL)Antraceno [PDF]

, 2015
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências Físicas e Matemáticas, Programa de Pós-Graduação em Química, Florianópolis, 2015Neste trabalho é descrito o planejamento, síntese e caracterização de uma série de novos ...
Ratto Neto, Carlos Alberto
core  

The effects of azo-oxadiazole-based bent-shaped molecules on the temperature range and the light-responsive performance of blue phase liquid crystal

, 2019
A series of light-responsive azo-oxadiazole-based bent-shaped molecules was synthesised and characterised. Their effects as dopants on the blue phases (BPs) range of the chiral nematic liquid crystal (N*LC) matrix and light-responsive properties ...
Yong-Bo Yu (594692), Dong Wang (73290), Wan-Li He (3960296), Lei Ren (277946), Hui Cao (182176), Zi-Mo Jiang (6522065), Ying Lu (66401), Zhou Yang (329522), Zhao-Feng Yu (6522068)   +8 more
core   +1 more source

Harnessing benzamides as plant stress inhibitors, growth promoters and in management of crop resilience—A review

Plant Biology, EarlyView.
Benzamides boost crop resilience by inhibiting poly(ADP‐ribose) polymerase (PARP) to enhance stress tolerance and, through their antimicrobial, herbicidal, and insecticidal derivatives, they offer broad protection for sustainable crop improvement. Abstract Benzamides have emerged as potent stress inhibitors and growth promoters in plant biotechnology ...
M. J. Koetle, T. E. Motaung, S. O. Amoo
wiley   +1 more source

Synthesis, Characterization and Antifungal Evaluation of 5-Substituted-4-Amino-1,2,4-Triazole-3-Thioesters

Molecules, 2011
A series of 5-substituted-4-amino-1,2,4-triazole-3-thioesters was synthesized by converting variously substituted organic acids successively into the corresponding esters, hydrazides, 5-substituted-1,3,4-oxadiazole-2-thiols, 5-substituted-1,2,4-triazole ...
Aurangzeb Hasan, Shelly Gapil, Noel Francis Thomas   +2 more
doaj   +1 more source

Modification of Chitosan and Polymethyl methacrylate with 5-Phenyl-1,3,4-oxadiazole Derivatives and their Antifungal Activity [PDF]

Delta Journal of Science, 2019
Functionalization of chitosan (Cs) and modified polymethylmethacrylate (PMMA) with 5-phenyl-1,3,4-oxadiazole derivatives was achieved for biological applications. Reaction of 5-phenyl-1,3,4-oxadiazole-2-thiol (1) with both Cs and functionalized PMMA with
E. G. I. Hamada, Ahmed A. Elbarbary, El-Refaie Kenawy   +2 more
doaj   +1 more source

Pyridines from azabicyclo[3.2.0]hept-2-en-4-ones through a proposed azacyclopentadienone

, 2012
Pyridines have been formed by heating azabicyclo[3.2.0]hept-2-en-4-ones in toluene. The generation of a 3-azacyclopentadienone intermediate via a [2+2]-cycloreversion is proposed as the key step.
Khan, Musharraf, Khan, Musharraf N., Vishnu V. R. Kondakal, M. Ilyas Qamar, Qamar, M. Ilyas, Hemming, Karl, Rice, Craig R., Karl Hemming, Craig R. Rice, Kondakal, Vishnu V.R., Qamar, Muhammad Ilyas, Arnaud Pitard, Pitard, Arnaud, Musharraf N. Khan, Kondakal, Vishnu   +14 more
core   +1 more source

2‐Pyrazoline‐5‐One Derivative Suppresses Cell Proliferation and Induces Apoptosis With Upregulation of Bax in Breast Cancer Cells

Journal of Biochemical and Molecular Toxicology, Volume 40, Issue 7, July 2026.
2‐Pyrazoline‐5‐one derivative inhibits proliferation and migration and induces Bax‐mediated apoptosis in breast cancer cells. ABSTRACT The most common cancer in women worldwide is still breast cancer. Among its subtypes, luminal A and triple‐negative breast cancers present significant therapeutic challenges due to intrinsic drug resistance and absence ...
Sevgi Kocyigit Sevinc, Ş. Güniz Küçükgüzel, Sevim Rollas, Fulya Yukcu   +3 more
wiley   +1 more source

Multi‐Targeting Ligands as Prospective Therapeutics for Alzheimer's Disease, a Prevalent Neurodegenerative Disorder: Mechanistic Insights, Emerging Targets and Drug Discovery Campaigns

Medicinal Research Reviews, Volume 46, Issue 4, Page 1173-1229, July 2026.
ABSTRACT Alzheimer's disease (AD) is a debilitating neurodegenerative condition characterized by progressive cognitive impairment, memory deterioration, and neuronal dysfunction. Its complex pathophysiology involves multiple interlinked processes, including amyloid‐β (Aβ) aggregation, tau hyperphosphorylation, oxidative stress, neuroinflammation ...
Amandeep Thakur, Mandeep Rana, Sakshi Vanjani, Kei‐Chi Liou, Rajeev Taliyan, Kunal Nepali, Chih‐Hao Yang   +6 more
wiley   +1 more source