Results 61 to 70 of about 7,227 (274)

Multi‐Targeting Ligands as Prospective Therapeutics for Alzheimer's Disease, a Prevalent Neurodegenerative Disorder: Mechanistic Insights, Emerging Targets and Drug Discovery Campaigns

Medicinal Research Reviews, EarlyView.
ABSTRACT Alzheimer's disease (AD) is a debilitating neurodegenerative condition characterized by progressive cognitive impairment, memory deterioration, and neuronal dysfunction. Its complex pathophysiology involves multiple interlinked processes, including amyloid‐β (Aβ) aggregation, tau hyperphosphorylation, oxidative stress, neuroinflammation ...
Amandeep Thakur, Mandeep Rana, Sakshi Vanjani, Kei‐Chi Liou, Rajeev Taliyan, Kunal Nepali, Chih‐Hao Yang   +6 more
wiley   +1 more source

In silico design, synthesis , DFT and Antimicrobial evaluation of some 2,5 substituted 1,3,4,Oxadiazole derivatives [PDF]

, 2017
In the present study, simple fourteen 2, 5 substituted 1,3,4- oxadiazole derivatives were subjected to molecular properties prediction and drug likeness by molinspriration software.
Gnanvel, S., Kannan, K., kavitha, S., Zulfareen, N.   +3 more
core   +2 more sources

Characterization of Structure, Properties, and Energetic Performance of a 1:1 Ammonium Dinitramide‐3,4‐Diaminofurazan Cocrystal

Propellants, Explosives, Pyrotechnics, EarlyView.
Ammonium dinitramide (ADN) and 3,4‐Diaminofurazan (DAF) form a 1:1 energetic cocrystal. We report its crystal structure and spectroscopic signature and evaluate thermal stability, decomposition behavior, hygroscopicity, and combustion properties. Propellant performance calculations benchmark the material against guanylurea dinitramide (GuDN) and ...
Peter Schultz, Uwe Schaller, Thomas Heintz   +2 more
wiley   +1 more source

Inhibition Effect of N, N'-Dimethylaminoethanol on the Corrosion of Austenitic Stainless Steel Type 304 [PDF]

, 2012
The effect of N,N'-dimethylaminoethanol on the corrosion of austenitic stainless steel type 304 in 3M H2SO4 has been studied by weight-loss method and linear polarization measurement in different concentrations of the compound.
Fedotova, T., Loto, C. A., Loto, R. T.
core   +1 more source

Synthesis and Characterization of an Azido Nitrofurazanyl Ether: An Energy‐Rich Heterocyclic Plasticizer With a Low Glass Transition Temperature

Propellants, Explosives, Pyrotechnics, EarlyView.
ABSTRACT We report on the synthesis and characterization of 3‐(2‐(2‐azidoethoxy)ethoxy)‐4‐nitro‐1,2,5‐oxadiazole (NFPEG2N3), which is a liquid nitrofurazanyl ether that was designed to be an energy‐rich plasticizer for glycidyl azide polymer (GAP)‐ and nitrocellulose (NC)‐based formulations.
P. Lieber, A. Omlor, U. Schaller, T. M. Klapötke   +3 more
wiley   +1 more source

Molecular Docking Studies of 2-Mercapto-5-(3-Methoxyphenyl) 1, 3, 4 Oxadiazole Thiones with Focal Adhesion Kinase [PDF]

, 2014
The main objective of the present work is to perform molecular docking studies of the ligand 2- Mercapto-5-(3-Methoxy phenyl) 1,3,4 oxadiazole with protein focal adhesion kinase. A good correlation was observed in binding affinity of this complex.
Guruprasad, R., Kiran, K.S., Kokila, M.K.   +2 more
core  

Advanced design and application for viologen‐based redox devices with customizable functionalities

Responsive Materials, EarlyView.
This review examines viologen‐based materials with customizable functionalities achieved through molecular engineering strategies such as side‐chain modification and composite formation. It emphasizes their utility in electrochromic devices, multicolor displays, and energy storage, while discussing stability challenges and outlining future development ...
Yuxin Chang, Yuchen Ge, Luzi Wang, Jinqian Mao, Zhongzhi Qu, Na Li, Dongqi Liu, Jiupeng Zhao   +7 more
wiley   +1 more source

A Review of Modern Methods of Synthesis 1, 3, 4-Oxadiazole as a Bioactive Compounds

Wasit Journal for Pure sciences, 2023
ABSTRACT: Oxadiazole ring is a heterocyclic molecule with an oxygen and two nitrogen atoms spread throughout its five-membered structure. There are four different isomers that have been discovered, Because of their wide applications in a range of sectors, including medications . Some of these biological activity are; anticonvulsant capacity, anticancer
openaire   +2 more sources

Preliminary structure-activity relationship studies on some novel s-substituted aliphatic analogues of 5-{1-[(4- chlorophenyl) sulfonyl]-3-piperidinyl}-1, 3, 4-oxadiazol-2-yl sulfide [PDF]

, 2016
Purpose: To study the structure-activity relationships of synthetic multifunctional sulfides through evaluation of lipoxygenase and anti-bacterial activities.Methods: S-substituted derivatives of the parent compound 5-(1-(4- chlorophenylsulfonyl ...
Abbasi, M. Athar, Ahmed, Irshad, Hassan, Sidra, Khan, Khalid M., Nafeesa, Khadija, Rehman, Aziz-ur-   +5 more
core   +2 more sources

Harnessing benzamides as plant stress inhibitors, growth promoters and in management of crop resilience—A review

Plant Biology, EarlyView.
Benzamides boost crop resilience by inhibiting poly(ADP‐ribose) polymerase (PARP) to enhance stress tolerance and, through their antimicrobial, herbicidal, and insecticidal derivatives, they offer broad protection for sustainable crop improvement. Abstract Benzamides have emerged as potent stress inhibitors and growth promoters in plant biotechnology ...
M. J. Koetle, T. E. Motaung, S. O. Amoo
wiley   +1 more source