Results 11 to 20 of about 3,073 (165)

Activity Profiling of Nitro-Substituted Di(Hetero)Aryl 1,3,4- and 1,2,4-Oxadiazoles: Antimicrobial, Cholinesterase Inhibition and Antioxidant Potential. [PDF]

Arch Pharm (Weinheim)
Novel nitro‐substituted diaryl 1,3,4‐ and 1,2,4‐oxadiazoles were synthesised via molecular hybridisation of bioactive heterocycles. Selected derivatives exhibited potent antimicrobial activity, including against Mycobacterium tuberculosis and Staphylococcus aureus, and cholinesterase inhibitory activity, with promising selectivity.
Šikorová E, Štěpánková Š, Frýbová E, Konečná K, Korbielová J, Švarcová M, Janďourek O, Pflégr V, Bősze S, Krátký M.   +9 more
europepmc   +2 more sources

Frame-Shifted Synthesis of Oligoheterocycles as a Platform for Molecular Design. [PDF]

Angew Chem Int Ed Engl
Modern chemistry seeks to turn the simple raw materials into complex molecules that matter in health, agriculture, and technology. Among these, oligoheterocycles stand out for their versatility, yet they are most often built by cross‐coupling reactions that often rely on expensive metal catalysts.
Bastick KAC, Griesbach CE, Huang BZ, Cordell MJ, Ou YD, Aspuru-Guzik A, Yudin AK.   +6 more
europepmc   +3 more sources

Synthesis of new hybrid quinazoline compounds as antiproliferative agents for breast and colon cancer treatment [PDF]

, 2022
Purpose: To evaluate newly synthesized fuoryl quinazoline derivatives for antitumor efficacy.Methods: Fuoryl quinazoline derivatives were synthesized and the structures of the synthesized compounds were characterized using standard techniques. The 3-(4,5-
Ahmed, Marwa F, Eed, Emad M, Khalifa, Amany S   +2 more
core   +2 more sources

Strategies against nonsense: oxadiazoles as translational readthrough-inducing drugs (TRIDs) [PDF]

, 2019
This review focuses on the use of oxadiazoles as translational readthrough-inducing drugs (TRIDs) to rescue the functional full-length protein expression in mendelian genetic diseases caused by nonsense mutations.
Campofelice A., Di Leonardo A., Lentini L., Melfi R., Pace A., Pibiri I., Tutone M.   +6 more
core   +1 more source

Design, synthesis, and biological investigation of oxadiazolyl, thiadiazolyl, and pyrimidinyl linked antipyrine derivatives as potential non-acidic anti-inflammatory agents [PDF]

, 2023
A novel series of 12 antipyrine derivatives containing 1,3,4-oxadiazoles (4a-d), 1,3,4-thiadiazoles (6a-d), and pyrimidines (8a-d), was preparedand assessed for its potential in vitro COX-2 inhibitors.
Al-Sanea M. M., Brogi S., Elshal M., Hamdi A., M Elbargisy R., Mohamed A. A. B., Mostafa E. M., Othman D. I. A., Parambi D. G. T., S Tawfik S., Selim S., Ur Rahman H.   +11 more
core   +1 more source

A convenient synthesis of 1,3,4-thiadiazole and 1,3,4-oxadiazole based peptidomimetics employing diacylhydrazines derived from amino acids [PDF]

, 2010
Synthesis of novel orthogonally protected 1,3,4-thiadiazole and 1,3,4-oxadiazole tethered dipeptide mimetics is described. Both the heterocycles are prepared via a set of diacylhydrazines derived from amino acids.
Lamani, R.S., Nagendra, G., Narendra, N., Sureshbabu, V.V.   +3 more
core   +1 more source

A Graphene Acid - TiO2 Nanohybrid as Multifunctional Heterogeneous Photocatalyst for the Synthesis of 1,3,4-Oxadiazoles [PDF]

, 2022
The immobilization of TiO2 nanoparticles on graphene acid (GA), a conductive graphene derivative densely functionalized with COOH groups, is presented.
Alemán Lara, José Julián, Barawi, Mariam, Blanco Fernández, Matías, De La Peña O. Shea, Víctor A., Navío, Cristina, Sciarretta, Martina   +5 more
core   +1 more source

Synthesis, characterization and antioxidant activity studies of new coumarin tethered 1,3,4-oxadiazole analogues [PDF]

, 2021
The present work describes the synthesis of a series of substituted 3-(5-phenyl-1,3,4-oxadiazol-2-yl)-2H-chromen-2-ones 7(a-j) using substituted aldehydes with analogues of hydrazine hydrates by grinding technique in the presence of Iodine which helps in
Ajay Kumar, K., Dileep Kumar, A., Sudeep, P., Vagish, C.   +3 more
core   +1 more source

Shaping 1,2,4-Triazolium Fluorinated Ionic Liquid Crystals [PDF]

, 2023
The synthesis and thermotropic behaviour of some di-alkyloxy-phenyl-1,2,4-triazolium trifluoromethane-sulfonate salts bearing a seven-carbon atom perfluoroalkyl chain on the cation is herein described. The fluorinated salts presenting a 1,2,4-triazole as
Buscemi S., Fiduccia I., Pace A., Palumbo Piccionello A., Pibiri I., Rizzo C.   +5 more
core   +1 more source

Syntheses, Evaluation and Characterization of Some 1, 3, 4‐Oxadiazoles as Antimicrobial Agents [PDF]

Journal of Chemistry, 2009
1,3,4‐Oxadiazoles show various biological activities and have been synthesized from different compounds. 1,3,4‐oxadiazole is popularly known for its antimicrobial, anti‐inflammatory, pesticidal and antihypertensive activities etc. It is well known that the synthesis of heterocyclic compounds tend to contain multi‐structure in a molecule.
Niti Bhardwaj, S. K. Saraf, Pankaj Sharma, Pradeep Kumar   +3 more
openaire   +2 more sources