Design, synthesis, and biological investigation of oxadiazolyl, thiadiazolyl, and pyrimidinyl linked antipyrine derivatives as potential non-acidic anti-inflammatory agents [PDF]
Journal of Enzyme Inhibition and Medicinal Chemistry, 2023 A novel series of 12 antipyrine derivatives containing 1,3,4-oxadiazoles (4a-d), 1,3,4-thiadiazoles (6a-d), and pyrimidines (8a-d), was preparedand assessed for its potential in vitro COX-2 inhibitors.
Mohammad M. Al-Sanea +11 more
doaj +3 more sources
Synthesis And Biological Activities Of 1, 3, 4-Oxadiazole Derivatives: A Review Of Literature. [PDF]
International Journal of Advanced Research, 2018 A series of derivatives of 1, 3, 4-oxadiazole having verities of biological activities can be synthesised by various methods. The activities include anticancer, antimicrobial, anti- inflammatory, anti- HIV, anti tubercular, anti diabetic, antifungal etc.
Baijika P +3 more
core +4 more sources
Synthesis and antimalarial activity of novel chiral and achiral benzenesulfonamides bearing 1, 3, 4-oxadiazole moieties [PDF]
Journal of Enzyme Inhibition and Medicinal Chemistry, 2007 A series of new benzenesulfonamides, most of which are chiral, incorporating 1, 3, 4-oxadiazole and amino acid moieties have been synthesized. Some of these compounds were screened for antimalarial activity and also evaluated for their ability to inhibit hem polymerization.
M. Zareef +6 more
openaire +8 more sources
The Role of Five-Membered Aromatic Rings Containing N and O in Modulating Bile Acid Receptors: An Overview. [PDF]
ChemMedChemSeveral derivatives incorporating five‐membered aromatic rings are described in this review as bile acid receptor modulators, particularly targeting the farnesoid X receptor and the G protein‐coupled bile acid receptor 1. This review provides a comprehensive analysis of patents and literature that is useful to support researchers in the design of new ...
Finamore C +5 more
europepmc +2 more sources
Synthesis and Biological evalution of some substituted 2-dibenzyl amino 1,3,4-oxadiazoles , thiadiazoles and 1,2,4-triazoles [PDF]
مجلة التربية والعلم, 2013 In this paper the synthesis of some substituted 2-dibenzyl 1,3,4-oxadiazole, thiadiazole and 1,2,4-triazoles derived from dibenzyl amine is reported scheme-1.
Khalid Daoud, Shaima Ismmaeel
doaj +1 more source
2D-QSAR study of synthesized novel derivatives of 1,3,4- Oxadiazoles as anti-inflammatory activity
BLDE University Journal of Health Sciences, 2020 Oxadiazole is a five-membered heterocyclic compound containing oxygen and two nitrogen atoms at C-1, C-3 and C-4 positions respectively. These derivatives are synthesized by both conventional as well as microwave-assisted.
M Somashekhar, R B Kotnal
doaj +1 more source
Synthesis of some substituted 1,3,4-oxadiazoles, 1,3,4-thiadiazoles and 1,2,4-triazoles from 2-(2,3-dimethylphenyl amino) benzoic acid [PDF]
مجلة التربية والعلم, 2009 In this paper the synthesis of some substituted 1,3,4-oxadiazoles, 1,3,4-thiadiazoles and 1,2,4-triazoles was achieved. 2-(2,3-dimethyl phenyl amino) benzoic acid was esterified to its ethyl ester by its reaction with absolute ethanol in presence of ...
Khalid Daoud +2 more
doaj +1 more source
Pharmaceuticals, 2022 2,5-Disubstituted 1,3,4-oxadiazoles are privileged versatile scaffolds in medicinal chemistry that have exhibited diverse biological activities. Acetyl- (AChE) and butyrylcholinesterase (BChE) inhibitors are used, e.g., to treat dementias and myasthenia ...
Václav Pflégr +5 more
doaj +1 more source
Synthesis of some substituted 1,3,4-oxadiazoles, thiadiazoles and 1,2,4-triazoles [PDF]
مجلة التربية والعلم, 2009 In this paper the synthesis of some substituted 1,3,4-oxadiazoles, 1,3,4-thiadiazoles and 1,2,4-triazoles is reported. Ethyl methacrylate was treated with hydrazine hydrate in ethanol to give the corresponding hydrazide (1).
Shereen R. Mohamed
doaj +1 more source
Synthesis of new hybrid quinazoline compounds as antiproliferative agents for breast and colon cancer treatment [PDF]
, 2022 Purpose: To evaluate newly synthesized fuoryl quinazoline derivatives for antitumor efficacy.Methods: Fuoryl quinazoline derivatives were synthesized and the structures of the synthesized compounds were characterized using standard techniques. The 3-(4,5-
Ahmed, Marwa F +2 more
core +2 more sources