Results 21 to 30 of about 12,849,117 (223)
Synthesis and antimicrobial activity of some new pyrazolo[3,4-b] pyrazines and related heterocycles [PDF]
Assiut University Journal of Multidisciplinary Scientific Research, 2018 3-Methyl-1-phenyl-6-pyrrol-1-yl-1H-pyrazolo[3,4-b]pyrazine-5-carboxylic acid hydrazide (5) could be obtained in a four-step reaction starting from 6-amino-3-methyl-1-phenyl-1H-pyrazolo[3,4-b]pyrazine-4-carbonitrile 1.
doaj +1 more source
Molecules, 2022 Dipeptidyl peptidase-IV (DPP-IV) inhibitors, often known as gliptins, have been used to treat type 2 diabetes mellitus (T2DM). They may be combined with other medications as an additional treatment or used alone as a monotherapy.
Badrud Duza Mohammad +8 more
doaj +1 more source
Journal of Enzyme Inhibition and Medicinal Chemistry, 2023 A novel series of 12 antipyrine derivatives containing 1,3,4-oxadiazoles (4a-d), 1,3,4-thiadiazoles (6a-d), and pyrimidines (8a-d), was preparedand assessed for its potential in vitro COX-2 inhibitors.
Mohammad M. Al-Sanea +11 more
doaj +1 more source
ANTIMICROBIAL ACTIVITY OF 1, 3, 4-OXADIAZOLES: A REVIEW
International Journal of Medical Sciences and Pharma Research, 2016 This review provides readers with an overview of their broad spectrum of pharmacological activities for 1, 3, 4-oxadiazole derivatives, and as reported over the past years. The search for new antimicrobial agents will consequently always remain as an important and challenging task for medicinal chemists.
, Himanshu, Vivek Kumar Joshi
openaire +1 more source
Synthesis, Reactions and Antioxidant Activity of 5-(3', 4'-dihydroxy-tetrahydrofuran-2'-yl)-2-methyl-3-carbohydrazide [PDF]
Iranian Journal of Chemistry & Chemical Engineering, 2019 In this manuscript, we describe the synthesis of the carbohydrazide 2. Acid-catalyzed condensation with several carbonyl compounds to afford the corresponding carbohydrazide derivatives 3-12.
Mohamed El Sadek +4 more
doaj
Expanding Synthesizable Space of Disubstituted 1,2,4-Oxadiazoles
, 2017 One-pot synthesis of 3,5-disubstituted 1,2,4-oxadiazoles from carboxylic acids and nitriles was optimized to parallel chemistry. The method was validated on a 141 member library; the desired products were recovered with a high success rate and in ...
Andrey Tolmachev (1514266) +10 more
core +1 more source
Synthesis and antimicrobial activity of 2,5-bis(Pyrazol-3-yl or Triazol-4-yl)-1,3,4-oxadiazoles [PDF]
, 2022 The reaction of pyrazole-3-carbohydrazide (1) or 1,2,3-triazole-4-carbohydrazides 5a,b and 2-(ethoxymethylene)malononitrile (2) in ethanol under reflux conditions afforded the corresponding N,N'-diacylhydrazines 3 or 6a,b, respectively in high yields ...
Mohamed, Hanan A. +4 more
core +1 more source
, 2016 The scope of intramolecular Diels−Alder and a novel tandem Diels−Alder/1,3-dipolar cycloaddition cascade of 1,3,4-oxadiazoles is disclosed. In the cases examined, the tandem cycloadditions construct three new rings with formation of four new C−C bonds ...
Dale L. Boger (1306542) +7 more
core +1 more source
E-Journal of Chemistry, 2011 A series of new 3-isoxazoline substituted phthalazine methylsulfonyl-oxadiazoles were prepared from methyl 2-(4-oxo-3,4-dihydrophthalazin-1-yl) acetate.
A. M. Sridhara +5 more
doaj +1 more source
Angewandte Chemie, Volume 138, Issue 41, 5 October 2026.Modular access to underexplored C5‐sulfenyl thiazoles via an intermolecular Pummerer rearrangement is reported. The methodology exhibits a broad functional group tolerance enabling the seamless design of trisubstituted thiazole cores bearing a sulfur handle for further elaboration.
Joe L. Smy +5 more
wiley +2 more sources