Results 21 to 30 of about 9,297,922 (227)
Фармацевтичний журнал, 2019 1,3,4-Thiadiazole and oxadiazole hetetocycles are well-known pharmacophore scaffolds, which possess wide possibility for chemical modification and identified diverse pharmacological potential.
M. I. Lelyukh
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Bioactive Oxadiazoles 2.0 [PDF]
, 2022 Oxadiazoles are electron-poor, five-membered aromatic heterocycles that contain one oxygen and two nitrogen atoms [...
Antonio Palumbo Piccionello
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Toxicological Evaluation of Anti-Scrapie Trimethoxychalcones and Oxadiazoles
Anais da Academia Brasileira de Ciências, 2015 An altered form of the cellular prion protein, the PrPScor PrPRes, is implicated in the occurrence of the still untreatable transmissible spongiform encephalopathies.
CLAUDIA P. FIGUEIREDO +10 more
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Synthesis and Antineoplastic Evaluation of Novel Unsymmetrical 1,3,4-Oxadiazoles [PDF]
, 2016 A series of novel 1,3,4-oxadiazoles was synthesized and evaluated for their cytotoxic activity in in vitro tumor models. Four of the new compounds (2d, 2j, 2k, and 2n) showed growth inhibition in the XTT dye assay.
Giansalvo Pinna (3367052) +7 more
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2:1 Adducts Arising from Reactions between Benzynes and 1,3,4-Oxadiazoles [PDF]
2:1 adducts arise from the reaction of 2,5-diaryl-1,3,4-oxadiazoles and benzynes generated from the hexadehydro-Diels–Alder (HDDA) reaction. Density functional theory computations support a mechanistic manifold that includes a concerted SNAr process ...
Paul V. Kevorkian (10522165) +2 more
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Oxidative Cyclization Protocol for the Preparation of Energetic 3‑Amino-5‑R‑1,2,4-oxadiazoles [PDF]
, 2018 An efficient method has been developed for the synthesis of energetic 3-amino-5-R-1,2,4-oxadiazoles via iodobenzene diacetate (IBD)-mediated oxidative cyclization in high yields at ambient temperature.
Jean’ne M. Shreeve (1267290) +3 more
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ANTIMICROBIAL ACTIVITY OF 1, 3, 4-OXADIAZOLES: A REVIEW
International Journal of Medical Sciences and Pharma Research, 2016 This review provides readers with an overview of their broad spectrum of pharmacological activities for 1, 3, 4-oxadiazole derivatives, and as reported over the past years. The search for new antimicrobial agents will consequently always remain as an important and challenging task for medicinal chemists.
, Himanshu, Vivek Kumar Joshi
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Oxadiazoles in Medicinal Chemistry [PDF]
, 2016 Oxadiazoles are five-membered heteroaromatic rings containing two carbons, two nitrogens, and one oxygen atom, and they exist in different regioisomeric forms.
Eric Wellner (1589959) +4 more
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Synthesis and antimicrobial activity of some new pyrazolo[3,4-b] pyrazines and related heterocycles [PDF]
Assiut University Journal of Multidisciplinary Scientific Research, 2018 3-Methyl-1-phenyl-6-pyrrol-1-yl-1H-pyrazolo[3,4-b]pyrazine-5-carboxylic acid hydrazide (5) could be obtained in a four-step reaction starting from 6-amino-3-methyl-1-phenyl-1H-pyrazolo[3,4-b]pyrazine-4-carbonitrile 1.
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Molecules, 2022 Dipeptidyl peptidase-IV (DPP-IV) inhibitors, often known as gliptins, have been used to treat type 2 diabetes mellitus (T2DM). They may be combined with other medications as an additional treatment or used alone as a monotherapy.
Badrud Duza Mohammad +8 more
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