Results 41 to 50 of about 3,269 (232)

Synthesis and antimalarial activity of novel chiral and achiral benzenesulfonamides bearing 1, 3, 4-oxadiazole moieties. [PDF]

, 2007
A series of new benzenesulfonamides, most of which are chiral, incorporating 1, 3, 4-oxadiazole and amino acid moieties have been synthesized. Some of these compounds were screened for antimalarial activity and also evaluated for their ability to inhibit
Claudiu T. Supuran, Javid H. Zaidi, Juan Rodrigues, Muhammad Arfan, Muhammad Zareef, Neira Gamboa de Domínguez, Rashid Iqbal   +6 more
core   +2 more sources

Molecular docking studies of 1, 3, 4 oxadiazoles Derivatives as anti-convulsive agents [PDF]

World Journal of Advanced Research and Reviews, 2020
Molecular docking is a computational technique that places a small molecule (ligand) in the binding site of its macromolecular target (receptor) and estimates its binding affinity. The present study attempted the high throughput in-silico screening of 65 compounds docked with the GABAA receptor (PDB ID: 4COF) using Molegro virtual docker (6.0).
Jangra, Sachin, Kumar, Sachin, Manjusha Choudhary   +2 more
openaire   +1 more source

Structural Variations in the Central Heterocyclic Scaffold of Tripartite 2,6-Difluorobenzamides: Influence on Their Antibacterial Activity against MDR Staphylococcus aureus

Molecules, 2022
Five series of heterocyclic tripartite 2,6-difluorobenzamides, namely 1,2,3-triazoles, 1,2,4- and 1,3,4-oxadiazoles, analogs of reported model anti-staphylococcal compounds, were prepared. The purpose was to investigate the influence of the nature of the
Thibaut Barbier, Cédric Badiou, Floriane Davy, Yves Queneau, Oana Dumitrescu, Gérard Lina, Laurent Soulère   +6 more
doaj   +1 more source

ANTIMICROBIAL ACTIVITY OF 1, 3, 4-OXADIAZOLES: A REVIEW

International Journal of Medical Sciences and Pharma Research, 2016
This review provides readers with an overview of their broad spectrum of pharmacological activities for 1, 3, 4-oxadiazole derivatives, and as reported over the past years. The search for new antimicrobial agents will consequently always remain as an important and challenging task for medicinal chemists.
, Himanshu, Vivek Kumar Joshi
openaire   +1 more source

Isosteric Substitution Enables Rational Design of Two‐Dimensional Energetic Crystals

Advanced Science, EarlyView.
Isosteric substitution transforms a classical nitro–amine motif into two‐dimensional aminofurazans with performance beyond TATB. ABSTRACT Two‐dimensional (2D) energetic crystals dissipate mechanical insult via interlayer slip, yet their molecular design space remains narrow.
Linyuan Wen, Wentong Tu, Tao Yu, Chao Chen, Zhixiang Zhang, Zhixiang Xie, Yingzhe Liu   +6 more
wiley   +1 more source

Decoupling Intrinsic Molecular Efficacy From Platform Effects: An Interpretable Machine Learning Framework for Unbiased Perovskite Passivator Discovery

Advanced Science, EarlyView.
This study establishes an interpretable machine learning framework that disentangles the intrinsic molecular efficacy of passivators from experimental platform effects—enabling unbiased, high‐throughput discovery of effective perovskite surface modifiers.
Jing Zhang, Ziyuan Li, Shan Gao, Zhen Zhu, Jing Wang, Xiangmei Duan   +5 more
wiley   +1 more source

Design, synthesis, characterization and computational docking studies of novel sulfonamide derivatives [PDF]

This study reports three novel sulfonamide derivatives 4-Chloro-N-[(4-methylphenyl) sulphonyl]-N-propyl ben- zamide (1A), N-(2-hydroxyphenyl)-4-methyl benzene sulfonamide (1B) and 4-methyl-N-(2-nitrophenyl) ben- zene sulfonamide (1C).
Ashiq, Ayesha, Bokhari, Saleem Ahmed, Khalid, Rana Rehan, Maryam, Arooma, Qureshi, Fahim Ashraf, Rauf, Sadaf Abdul, Saleem, Hira, Siddiqi, Abdul Rauf   +7 more
core   +1 more source

Reaktionen von 3-Dimethylamino-2,2-dimethyl-2H-azirin mit aromatischen Carbonsäurehydraziden

CHIMIA, 1978
Reaction of 3-dimethylamino-2,2-dimethyl-2H-azirine (1) with salicylic acid hydrazide (2c) in acetonitrile at room temperature gives the amidrazone 3c as a primary product in 78% yield. Cyclization of 3c in methanol leads to the 1,2,5,6-tetrahydro-1,2,4-
Stanislav Chaloupka, Heinz Heimgartner
doaj   +1 more source

Synthesis and Antimicrobial Evaluation of Some New Oxadiazoles Derived from Phenylpropionohydrazides

Molecules, 2009
In this study a series ofnew1-(2-aryl-5-phenethyl-1,3,4-oxadiazol-3(2H)-yl)ethanones 2a-e was synthesized by the cyclization of imines 1a-e using acetic anhydride. The products were evaluated for anti-bacterial and anti-fungal activity.
Mohammad Ali, Mohammad Shaharyar, Neeraj Kumar Fuloria, Vijender Singh   +3 more
doaj   +1 more source

Synthesis of 2, 5-disubstituted-1, 3, 4-oxadiazole derivatives

Journal of Drug Delivery and Therapeutics, 2019
Synthesis of a series of various 2, 5-disubstituted-1, 3, 4-oxadiazole derivatives (7a-7u) have been done. Synthesis of a series of intermediates (3a-3c and 5a-5c) have been also done, ethyl-2-phenoxyacetate (3a), ethyl 2-(2, 4-dichlorophenoxy)acetate (3b), ethyl 2-(4-nitrorophenoxy) acetate (3c), 2-phenoxyacetohydrazide (5a), 2-(2, 4-dichlorophenoxy ...
Raghvendra Singh Bhadauria, Neetesh Kumar Sharma, Sanwar Mal Solet   +2 more
openaire   +1 more source