Results 61 to 70 of about 2,991 (181)

Synthesis, toxicity towards brine shrimp (Artemia salina Leach) and antimicrobial activity evaluation of 3,5-diphenylchlorinated-1,2,4- oxadiazoles = Síntese, toxicidade frente a Artemia salina Leach e avaliação da atividade antimicrobiana de 1,2,4-oxadiazóis-3,5-difenilclorados

Acta Scientiarum: Technology, 2005
The known oxadiazoles 3,5-bis-(phenyl)-1,2,4-oxadiazole (3a); the 3-(4-chlorophenyl)-5-phenyl-1,2,4-oxadiazole (3b); and the new 3,5-diphenylchlorinated-1,2,4-oxadiazoles 3c-e were synthesized from the reaction of benzamidoximes with an appropriated acid
Silvio Luiz Machado, Luciane Vieira dos Santos, Willian Ferreira da Costa, Benedito Prado Dias Filho, Maria Helena Sarragiotto   +4 more
doaj  

A Review of Modern Methods of Synthesis 1, 3, 4-Oxadiazole as a Bioactive Compounds

Wasit Journal for Pure sciences, 2023
ABSTRACT: Oxadiazole ring is a heterocyclic molecule with an oxygen and two nitrogen atoms spread throughout its five-membered structure. There are four different isomers that have been discovered, Because of their wide applications in a range of sectors, including medications . Some of these biological activity are; anticonvulsant capacity, anticancer
openaire   +2 more sources

Decoupling Intrinsic Molecular Efficacy From Platform Effects: An Interpretable Machine Learning Framework for Unbiased Perovskite Passivator Discovery

Advanced Science, Volume 13, Issue 41, 22 July 2026.
This study establishes an interpretable machine learning framework that disentangles the intrinsic molecular efficacy of passivators from experimental platform effects—enabling unbiased, high‐throughput discovery of effective perovskite surface modifiers.
Jing Zhang, Ziyuan Li, Shan Gao, Zhen Zhu, Jing Wang, Xiangmei Duan   +5 more
wiley   +1 more source

5-Furan-2yl[1,3,4]oxadiazole-2-thiol, 5-Furan-2yl-4H [1,2,4] triazole-3-thiol and Their Thiol-Thione Tautomerism

Molecules, 2005
5-Furan-2-yl[1,3,4]oxadiazole-2-thiol (Ia) and 5-furan-2-yl-4H-[1,2,4]-triazole-3-thiol (Ib) were synthesized from furan-2-carboxylic acid hydrazide. Mannich basesand methyl derivatives were then prepared.
A. Cansız, A. Çetin, M. Koparır   +2 more
doaj   +1 more source

The Solid‐State Emission of AIPE‐Active Tricarbonylrhenium(I) Complexes Shifts to the Red: The Unexpected Performance of Triphenylphosphine Derivatives

Aggregate, Volume 7, Issue 7, July 2026.
New phosphino tricarbonylrhenium(I) complexes have efficient red emission in the aggregate and solid states. The good photostability and the vast possibilities of chemical modifications make these Re‐based complexes the starting point of a new generation of red emitters with aggregation‐induced phosphorescence emission (AIPE) characteristics.
Valentine Guilbaud, Mariusz Wolff, Maëlle Deleuzière, Evelyne Delfourne, Corinne Vanucci‐Bacqué, Charles‐Louis Serpentini, Sonia Mallet‐Ladeira, Eric Benoist, Suzanne Fery‐Forgues   +8 more
wiley   +1 more source

SYNTHESIS AND BIOLOGICAL EVALUATION OF 1H-(INDOLE-5-YL)-3-SUBSTITUTED-1,2,4-OXADIAZOLES AS NOVEL 5-LOX INHIBITORS

Journal of the Turkish Chemical Society, Section A: Chemistry
: A series of indolyloxadiazoles were synthesized from amidoxime and indole 3-carboxaldehyde using CAN as a catalyst and PEG as a solvent. In vitro, a 5-LOX inhibitory assay has been performed for all the synthesized compounds. Among the tested compounds,
Siddaiah Vidavalur, Sunanda Kumari Kadiri, Berihu Tekluu   +2 more
doaj   +1 more source

2‐Pyrazoline‐5‐One Derivative Suppresses Cell Proliferation and Induces Apoptosis With Upregulation of Bax in Breast Cancer Cells

Journal of Biochemical and Molecular Toxicology, Volume 40, Issue 7, July 2026.
2‐Pyrazoline‐5‐one derivative inhibits proliferation and migration and induces Bax‐mediated apoptosis in breast cancer cells. ABSTRACT The most common cancer in women worldwide is still breast cancer. Among its subtypes, luminal A and triple‐negative breast cancers present significant therapeutic challenges due to intrinsic drug resistance and absence ...
Sevgi Kocyigit Sevinc, Ş. Güniz Küçükgüzel, Sevim Rollas, Fulya Yukcu   +3 more
wiley   +1 more source

Synthesis and cytotoxic evaluation of some quinazolinone- 5-(4-chlorophenyl) 1, 3, 4-oxadiazole conjugates

Research in Pharmaceutical Sciences, 2019
1, 3, 4- Oxadiazoles and quinazolinones are privileged structures with extensive biological activities. On account of reported anticancer activity of them, in this study, a multi-step reaction procedure has been developed for the synthesis of some ...
Farshid Hassanzadeh, Hojjat Sadeghi-Aliabadi, Elham Jafari, Azadeh Sharifzadeh, Nasim Dana   +4 more
doaj   +1 more source

SYNTHESIS AND EVALUATION OF ANTITUBERCULAR ACTIVITY OF 1, 3, 4-OXADIAZOLE DERIVATIVES

Asian Journal of Pharmaceutical and Clinical Research
Objective: The present study aimed to design, synthesize, and evaluate two novel series of 1,3,4-oxadiazole derivatives for their antitubercular activity against Mycobacterium tuberculosis H37Rv, supported by molecular docking and absorption, bio-distribution, metabolism, and excretion (ADME) predictions to identify potential lead molecules.
null NAMITHA KN, null VELMURUGAN V
openaire   +1 more source

Synthesis, Cytotoxicity, Xanthine Oxidase Inhibition, Antioxidant of New Pyrazolo{3,4 d}Pyrimidine Derivatives

مجلة بغداد للعلوم, 2019
Allopurinol derivative were prepared by reacting the (1-chloroacetyl)-2-Hydropyrazolo{3,4-d}pyrimidine-4-oneiwith 5- methoxy- 2-aminoibenzothiazoleiunder certain conditions to obtain new compound  ( N- (2-aminoacetyl (5-methoxy) benzothiazole -2yl) (A4),
Khammas et al.
doaj   +1 more source