Results 51 to 60 of about 12,849,117 (223)

Advancing Therapies for Mycobacterial Diseases: From Small Molecules to Host‐Directed Strategies

Medicinal Research Reviews, EarlyView.
ABSTRACT The global burden of multidrug‐resistant tuberculosis (MDR‐TB) and the rising incidence of nontuberculous mycobacterial (NTM) infections highlight the urgent need for innovative therapeutic strategies. Current treatments are prolonged, toxic, and increasingly compromised by resistance and limited diagnostic capacity.
Tânia Silva, Alessandra Aiello, Tonino Alonzi, M. Alice Carvalho, Vladimir Finger, Delia Goletti, Sven Hoffner, Yousra Kherabi, Jan Korabecny, Julia Kulczyńska, Agnieszka Kyzioł, Alicia Lacoma, Filomena Martins, Zorica Nanovic, Sepideh Hosseiniporgham, Martina Hrast Rambaher, Leonardo Antonio Sechi, Daria Smalchuk, Grażyna Stochel, Lydia Tabernero, Nancy L. Tateosian, Violeta Valcheva, Anamarija Zega, Mafalda Sarraguça   +23 more
wiley   +1 more source

Synthesis and Antimicrobial Evaluation of Some New Oxadiazoles Derived from Phenylpropionohydrazides

Molecules, 2009
In this study a series ofnew1-(2-aryl-5-phenethyl-1,3,4-oxadiazol-3(2H)-yl)ethanones 2a-e was synthesized by the cyclization of imines 1a-e using acetic anhydride. The products were evaluated for anti-bacterial and anti-fungal activity.
Mohammad Ali, Mohammad Shaharyar, Neeraj Kumar Fuloria, Vijender Singh   +3 more
doaj   +1 more source

Oxaziridines: Versatile Reagents in Modern Organic Synthesis

The Chemical Record, EarlyView.
Being capable of transferring an O atom and N‐group/atom, oxaziridines are considered multitasking agents. These are employed for diverse organic transformations, such as epoxidation of olefins, α‐ and γ‐hydroxylation/amination of carbonyl compounds, oxidation of sulfides, [3+2]cycloaddition with unsaturated systems.
Ajeet Chandra, Subba Rao Cheekatla, Keshaba Nanda Parida   +2 more
wiley   +1 more source

1, 3, 4-Oxadiazoles : Part III. Mannich Bases Derived from 5-(o-) Hydroxyphenyl-1, 3, 4-Oxadiazol-2-thione

, 1974
Department Of Chemistry, S. C. College, Ballia Manuscript received 17 September 1973; revised 28 March 1974; accepted 4 April 1974 A number of 3-substituted aminomethy1-5-(o-)hydroxyphenyl-1, 3, 4-oxadiazol-2-thiones have been prepared by the application of Mannich reaction.
VISHNU JI RAM, H. N. PANDEY
openaire   +2 more sources

Harnessing benzamides as plant stress inhibitors, growth promoters and in management of crop resilience—A review

Plant Biology, EarlyView.
Benzamides boost crop resilience by inhibiting poly(ADP‐ribose) polymerase (PARP) to enhance stress tolerance and, through their antimicrobial, herbicidal, and insecticidal derivatives, they offer broad protection for sustainable crop improvement. Abstract Benzamides have emerged as potent stress inhibitors and growth promoters in plant biotechnology ...
M. J. Koetle, T. E. Motaung, S. O. Amoo
wiley   +1 more source

Ring transformations of heterocycles. Part 1. Transformation of 4‐amino‐Δ2‐1,2,4‐oxadiazolines into 1,3,4‐oxadiazoles

, 1991
3‐Aryl‐4‐amino‐δ2‐1,2,4‐oxadiazolines 3 and their N‐chloroacetyl derivatives 4, upon treatment with chloroacetic anhydride in refluxing toluene, afford 2‐chloromethyl‐5‐aryl‐1,3,4‐oxadiazoles 5, suggesting the conversion sequence 3 → 4 → 5.
Woydt, M, El‐abadelah, MM, Rademacher, Paul, Awadallah, Adel M., Nazer, MZ, Hussein, AQ   +5 more
core   +1 more source

Development of Predictive Antioxidant Models for 1,3,4-Oxadiazoles by Quantitative Structure Activity Relationship

Journal of the Turkish Chemical Society, Section A: Chemistry, 2019
The free radical scavenging properties of 1,3,4-oxadiazoles have been explored by the application of quantitative structure activity relationship (QSAR) studies.
Ikechukwu Alisi, Adamu Uzairu, Stephen Eyije Abechi, Suleiman Ola Idris   +3 more
doaj   +1 more source

Design, Synthesis and Bioactivity Evaluation of Novel 2-(pyrazol-4-yl)-1,3,4-oxadiazoles Containing an Imidazole Fragment as Antibacterial Agents

Molecules, 2023
Imidazole alkaloids, a common class of five-membered aromatic heterocyclic compounds, exist widely in plants, animals and marine organisms. Because of imidazole’s extensive and excellent biological and pharmacological activities, it has always been a ...
Hongwu Liu, Shan Yang, Ting Li, Siyue Ma, Peiyi Wang, Guoqing Wang, Shanshan Su, Yue Ding, Linli Yang, Xiang Zhou, Song Yang   +10 more
doaj   +1 more source

The Expanding Role of Diazirines in Synthetic Methodology

European Journal of Organic Chemistry, Volume 29, Issue 38, 13 October 2026.
Beyond their established role in photoaffinity labeling, diazirines have emerged as versatile reagents in synthetic chemistry. This review highlights their dual reactivity as carbene and nitrogen‐transfer precursors, showcasing mechanistic insights and diverse applications in cyclopropanations, cycloadditions, skeletal editing, amination, heterocycle ...
Viktor Savic, Dominik Schnalzer, Marko D. Mihovilovic, Michael Schnürch   +3 more
wiley   +1 more source

Studies on 1,3,4-Oxadiazoles. Part-IX. Preparation and Antimicrobial Activity of 2-Phenyl-5-p-(2',4'-bis-ethylamino-s-triazin-6'-ylaminophenyl)-1 ,3,4,-oxadiazoles

, 1988
Department of Chemistry, Saurashtra University, Rajkot-360 005 Manuscript received 15 February 1987, revised 18 April 1988, accepted 17 May 2988 Studies on 1,3,4-Oxadiazoles. Part-IX.
HANSA PAREKH, C. L. PATEL
core   +1 more source