Results 51 to 60 of about 3,269 (232)

Mechanistic Paths for the Gold(I)‐Catalyzed Heteroannulation of Salicylic Amides With Apolar Alkynes Explored With Density Functional Theory Calculations

European Journal of Organic Chemistry, EarlyView.
A manifold of catalytic reaction paths can operate in the Au(I)‐catalyzed heteroannulation of salicylic amides and alkynes. However, a subtle initial nucleophilic advantage of N versus O and a kinetic bottleneck at an advanced stage of the mechanistic machinery seems to suffice for the reaction to run on a single path and with exquisite selectivity. We
Ioannis Stylianakis, Evaggelia Vlachou, Carlos Silva López, Antonios Kolocouris   +3 more
wiley   +1 more source

Design, Synthesis and Bioactivity Evaluation of Novel 2-(pyrazol-4-yl)-1,3,4-oxadiazoles Containing an Imidazole Fragment as Antibacterial Agents

Molecules, 2023
Imidazole alkaloids, a common class of five-membered aromatic heterocyclic compounds, exist widely in plants, animals and marine organisms. Because of imidazole’s extensive and excellent biological and pharmacological activities, it has always been a ...
Hongwu Liu, Shan Yang, Ting Li, Siyue Ma, Peiyi Wang, Guoqing Wang, Shanshan Su, Yue Ding, Linli Yang, Xiang Zhou, Song Yang   +10 more
doaj   +1 more source

Push–Pull Ynamines and Push–Pull Ynamides: Synthesis, Structure, Reactivity, and Application

European Journal of Organic Chemistry, EarlyView.
Push–pull ynamines and push–pull ynamides, which carry an EWG and an amino or amido group as EDG, are highly interesting classes of EDG‐EWG alkynes that have been intensively studied due to their exceptional reactivity. In this review, the synthesis, structure, reactivity, and application of push–pull ynamines, push–pull ynecarbamates, push–pull ...
Hans‐Joachim Gais
wiley   +1 more source

Development of Predictive Antioxidant Models for 1,3,4-Oxadiazoles by Quantitative Structure Activity Relationship

Journal of the Turkish Chemical Society, Section A: Chemistry, 2019
The free radical scavenging properties of 1,3,4-oxadiazoles have been explored by the application of quantitative structure activity relationship (QSAR) studies.
Ikechukwu Alisi, Adamu Uzairu, Stephen Eyije Abechi, Suleiman Ola Idris   +3 more
doaj   +1 more source

Multi‐Targeting Ligands as Prospective Therapeutics for Alzheimer's Disease, a Prevalent Neurodegenerative Disorder: Mechanistic Insights, Emerging Targets and Drug Discovery Campaigns

Medicinal Research Reviews, EarlyView.
ABSTRACT Alzheimer's disease (AD) is a debilitating neurodegenerative condition characterized by progressive cognitive impairment, memory deterioration, and neuronal dysfunction. Its complex pathophysiology involves multiple interlinked processes, including amyloid‐β (Aβ) aggregation, tau hyperphosphorylation, oxidative stress, neuroinflammation ...
Amandeep Thakur, Mandeep Rana, Sakshi Vanjani, Kei‐Chi Liou, Rajeev Taliyan, Kunal Nepali, Chih‐Hao Yang   +6 more
wiley   +1 more source

Synthesis of some new 4-(2,4-dimethyl-phenyl)-2H-phthalazinone derivatives

Journal of Scientific Research in Science, 2021
Aroylation of m-xylene by phthalic anhydride under Friedel craft’s reaction conditions to afford the corresponding o-aroylbenzoic acid derivative (2), which followed by cyclization reaction with hydroxylamine hydrochloride to produce the correlating ...
Mamdouh A. Taha, Ibrahim E. El-Shamy, Asmaa K. Mourad, Ahmed Th. Ali   +3 more
doaj   +1 more source

Characterization of Structure, Properties, and Energetic Performance of a 1:1 Ammonium Dinitramide‐3,4‐Diaminofurazan Cocrystal

Propellants, Explosives, Pyrotechnics, EarlyView.
Ammonium dinitramide (ADN) and 3,4‐Diaminofurazan (DAF) form a 1:1 energetic cocrystal. We report its crystal structure and spectroscopic signature and evaluate thermal stability, decomposition behavior, hygroscopicity, and combustion properties. Propellant performance calculations benchmark the material against guanylurea dinitramide (GuDN) and ...
Peter Schultz, Uwe Schaller, Thomas Heintz   +2 more
wiley   +1 more source

A Handy and Solventless Direct Route to Primary 3-[3-Aryl)-1,2,4-oxadiazol-5-yl]propionamides Using Microwave Irradiation

Molecules, 2006
A one-step, simple and straightforward synthesis of the title amides from the corresponding carboxylic acids, urea and imidazole under microwave irradiation is described.
Rajendra M. Srivastava, Ricardo A.W. Neves   +1 more
doaj   +1 more source

A one-pot synthesis-functionalization strategy for streamlined access to 2,5-disubstituted 1,3, 4-oxadiazoles from carboxylic acids [PDF]

, 2022
A one-pot 1,3,4-oxadiazole synthesis-arylation strategy for accessing 2,5-disubstituted 1,3,4-oxadiazoles, from carboxylic acids, N-isocyaniminotriphenylphosphorane (NIITP), and aryl iodides, is reported.
Dixon, Darren J, Matheau-Raven, Daniel
core   +2 more sources

Synthesis and Characterization of an Azido Nitrofurazanyl Ether: An Energy‐Rich Heterocyclic Plasticizer With a Low Glass Transition Temperature

Propellants, Explosives, Pyrotechnics, EarlyView.
ABSTRACT We report on the synthesis and characterization of 3‐(2‐(2‐azidoethoxy)ethoxy)‐4‐nitro‐1,2,5‐oxadiazole (NFPEG2N3), which is a liquid nitrofurazanyl ether that was designed to be an energy‐rich plasticizer for glycidyl azide polymer (GAP)‐ and nitrocellulose (NC)‐based formulations.
P. Lieber, A. Omlor, U. Schaller, T. M. Klapötke   +3 more
wiley   +1 more source