Results 31 to 40 of about 3,073 (165)
Chemistry &Biodiversity, Volume 23, Issue 1, January 2026.Initial screening of the synthesized compounds revealed that compounds MK175 and MK169 inhibited LPS‐induced IL‐1β release in human aortic smooth muscle cells. ABSTRACT Proinflammatory cytokine interleukin (IL)‐1β is a key mediator of the inflammatory response in atherosclerosis.
Dimitra T. Pournara +6 more
wiley +1 more source
DESIGN, SYNTHESIS AND ANTIFUNGAL EVALUATION OF NOVEL SUBSTITUTED 1, 3, 4-OXADIAZOLES, AND 1, 3, 4-THIADIAZOLES [PDF]
, 2015 Objective: The purpose of this research is to evaluate the antifungal activity of synthesized conjugates of thiophene with 1, 3, 4-oxadiazoles and 1, 3, 4-thiadiazoles using in vitro methods.Methods: The series of (IVa-e) and (Va-e) compounds were ...
Mishra, Pradeep, Upadhyay, Prabhat K
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Decoding Urease Inhibition: A Comprehensive Review of Inhibitor Scaffolds
ChemMedChem, Volume 21, Issue 2, January 2026.Representative functional groups known for urease inhibition are reviewed within diverse scaffolds using structure–activity analyses to identify features associated with high inhibitory activity. Urease is a metalloenzyme produced by a wide range of organisms and plays a critical role in nitrogen microbial metabolism by catalyzing the hydrolysis of ...
Nuno Martinho, Natália Aniceto
wiley +1 more source
DESIGN AND ANTIINFLAMATORY ACTIVITY OF SOME NOVEL OXADIAZOLE DERIVATIVES – AN OVERVIEW [PDF]
, 2013 Oxadiazole derivates play vital role in biological field suchas anti-microbial, anti-viral, anti-tubercular, antiinflammatoryand anti-convulsant activity. Therapeuticsignificance of these clinically useful drugs in treatment ofinflammation encouraged the
A MISHRA, AK MISHRA, A GUPTA, V GUPTA,
core +1 more source
ChemMedChem, Volume 21, Issue 1, January 2026.Investigation of the structure‐activity relationship on W482 (1) with a pyrimidine‐2,4‐diamine scaffold culminated in analog 51 with enhanced anti‐plasmodial activity. Forward genetics and phenotypic examination revealed the ABCI3 transporter protein as a putative resistance mechanism.
Mahta Mansouri +14 more
wiley +1 more source
A Hybrid Photo/Biocatalytic System for the Sustainable Synthesis of L‐Alanine From Urea and Pyruvate
ChemSusChem, Volume 19, Issue 2, January 2026.We present a visible‐light driven photo‐biocatalytic system combining urease (URE), L‐alanine dehydrogenase (AlDH) and visible‐light driven nicotinamide adenine dinucleotide (NADH) regeneration system consisting of triethanolamine (TEOA), zinc meso‐tetra(4‐sulfonatophenyl)porphyrin tetrasodium salt (ZnTPPS4‐) and [Cp*Rh(bpy)(H2O)]2+.
Kyosuke Yamada, Yutaka Amao
wiley +1 more source
Synthesis and antiviral activity of 2-3,5 dinitropheny1-5-substituted phenyl 1,3,4-oxadiazoles [PDF]
, 2020 3, 5 dinitro benzoic acid hydrazide was prepared by the hydrazinolysis of the corresponding ethyl ester. Condensation of this hydrazide with different aromatic acids in presence of POCl3 gave 2-3, 5 dinitropheny1-5-substituted pheny1 1, 3, 4-oxadiazoles.
Jyoti, Archana
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Synthesis, Characterization of some New 1, 3, 4-Oxadiazole derivatives based on 4- amino benzoic acid [PDF]
, 2016 In this research various of 2,5-disubstituted 1,3,4-oxadiazole (Schiff base, oxo-thiazolidine , and other compounds) were synthesized from 2,5-di(4,4?- amino-1,3,4-oxadiazole ) which use quently synthesized from mixture of 4-amino benzoic acid and ...
Al-Sahib, Sanaa A. +3 more
core +2 more sources
Piperazine Derivatives: A Privileged Scaffold in Modern Synthesis and Medicinal Chemistry
ChemistryOpen, Volume 15, Issue 1, January 2026.Piperazine‐based bioactive molecules represent a versatile class of compounds with broad therapeutic potential. Structural modification of the piperazine scaffold governs key structure–activity relationships, enabling antibacterial, antifungal, antitumor, neuroactive, and anti‐inflammatory activities.
Assel Ten +5 more
wiley +1 more source
The synthesis of potential analgesics derived from thebaine [PDF]
, 1979 The thesis describes the synthesis of novel bridged thebaine derivatives with heterocyclic rings attached to C-7 and a study of the associated chemistry. Use has been made of the α-hydrazide (3) formed from the α-ester (2), itself prepared by Diels-Alder
Michael Burton (4178776)
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