Results 61 to 70 of about 5,642 (192)

Profiling of HCAR1 signalling reveals Gαi/o and Gαs activation without β‐arrestin recruitment and the discovery of an allosteric agonist

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Lactate, historically viewed as a metabolic by‐product, has emerged as a signalling molecule via the G protein–coupled receptor Hydroxycarboxylic Acid Receptor 1 (HCAR1). The receptor is primarily expressed in adipocytes but also found in various other tissues.
Simon Lind, Shane C. Wright, Emilia Gvozdenovic, Kristina Nilsson, Kenneth L. Granberg, Michel Bouvier, Linda C. Johansson   +6 more
wiley   +1 more source

Efficient synthesis of novel benzo[b][1,8]naphthyridin-4(1H)-ones and pyrido[2,3-b]quinoxalin-4(1H)-ones from alkynones and primary amines [PDF]

, 2013
An efficient palladium-catalyzed cyclization of o-chlorohetaryl ynones with aliphatic and aromatic primary amines represents a simple access to a wide range of benzo[b][1,8]naphthyridin-4(1H)-one and pyrido[2,3-b]quinoxalin-4(1H)- one derivatives in good
Altenburger, K., Gevorgyan, A., Iaroshenko, V. O., Knepper, I., Langer, P., Mkrtchyan, S., Sosnovskikh, V. Y., Villinger, A., Zahid, M.   +8 more
core   +1 more source

Comparative evaluation of noncanonical amino acids as site‐specific NMR probes for the complex of E. coli SSB with single‐stranded DNA without isotope labelling

The FEBS Journal, EarlyView.
Genetic encoding of noncanonical amino acids (ncAA) enables their site‐specific installation in proteins. This work compares the nuclear magnetic resonance (NMR) performance of different ncAAs in a large protein−DNA complex (~ 100 kDa) without isotope labelling. The ncAAs deliver readily detectable NMR signals in the complex between E.
Sreelakshmi Mekkattu Tharayil, Haocheng Qianzhu, Elwy H. Abdelkader, Adarshi P. Welegedara, Josemon George, Christoph Nitsche, Thomas Huber, Gottfried Otting   +7 more
wiley   +1 more source

Asymmetric Negishi and Kumada Couplings

Advanced Synthesis &Catalysis, Volume 368, Issue 5, 3 March 2026.
This review summarizes asymmetric Negishi and Kumada cross‐coupling reactions from the 1980s through 2025. It examines enantioselective and enantiospecific transformations catalyzed by nickel, palladium, and cobalt complexes , highlighting ligand design, mechanistic insights, and applications in constructing complex chiral molecules and natural ...
Rui‐Heng Wang, Aishun Ding, Ramon Rios
wiley   +1 more source

Frame‐Shifted Synthesis of Oligoheterocycles as a Platform for Molecular Design

Angewandte Chemie, Volume 138, Issue 2, 9 January 2026.
Modern chemistry seeks to turn the simple raw materials into complex molecules that matter in health, agriculture, and technology. Among these, oligoheterocycles stand out for their versatility, yet they are most often built by cross‐coupling reactions that often rely on expensive metal catalysts.
Kane A. C. Bastick, Caleb E. Griesbach, Ben Zhen Huang, Morgan J. Cordell, Yang (Daniel) Ou, Alán Aspuru‐Guzik, Andrei K. Yudin   +6 more
wiley   +2 more sources

A study of substituent effects on the NH bond in alkyl and aryl 4,6-disubstituted-3-cyano-2-pyridones [PDF]

Journal of the Serbian Chemical Society, 2007
Substituent effects on the IR stretching frequencies and 1H-NMR chemical shifts of the pyridone NH group in 4- and 6-disubstituted alkyl and aryl 3-cyano- 2-pyridones were investigated.
Mišić-Vuković Milica, Jovanović Slobodanka, Mijin Dušan, Csanadi Janos, Đoković Dejan   +4 more
doaj   +3 more sources

New syntheses of 5,6- and 7,8-diaminoquinolines

Beilstein Journal of Organic Chemistry, 2013
The synthesis of 5,6- and 7,8-diaminoquinoline derivatives starting from angularly annelated selenadiazoloquinolones is presented. Simple chlorination of the pyridone ring followed by reductive deselenation of the 1,2,5-selenadiazole ring afforded novel ...
Maroš Bella, Viktor Milata
doaj   +1 more source

Cytotoxic hexadepsipeptides and anti-coronaviral 4-hydroxy-2-pyridones from an endophytic Fusarium sp.

Frontiers in Chemistry, 2023
Three new hexadepsipeptides (1–3), along with beauvericin (4), beauvericin D (5), and four 4-hydroxy-2-pyridone derivatives (6–9) were isolated from the endophytic fungus Fusarium sp. CPCC 400857 that derived from the stem of tea plant.
Shanshan Chang, Biying Yan, Yuchuan Chen, Wuli Zhao, Rongmei Gao, Yuhuan Li, Liyan Yu, Yunying Xie, Shuyi Si, Minghua Chen   +9 more
doaj   +1 more source

Dinuclear Rhodium(I)–N‐Heterocyclic Carbene Complexes as Alkyne Hydropyridonation Catalysts

European Journal of Inorganic Chemistry, Volume 29, Issue 7, 2 March 2026.
Catalyst Improvement by NHC tuning: A series of new RhI–NHC dinuclear complexes has been revealed as efficient alkyne hydropyridonation catalysts. 333053IMes complex displays the highest reactivity of the series, suggesting that a moderate steric demand combined with balanced σ‐donation facilitates precatalyst activation and substrate exchange.
Belinda Español‐Sánchez, Mert Olgun Karataş, Andrea Di Giuseppe, Ulugbek Togaev, Vincenzo Passarelli, Luis A. Oro, Jesús J. Pérez‐Torrente, Ricardo Castarlenas   +7 more
wiley   +1 more source

Synthesis, structure and solvatochromic properties of some novel 5-arylazo-6-hydroxy-4-phenyl-3-cyano-2-pyridone dyes

Chemistry Central Journal, 2012
Background A series of some novel arylazo pyridone dyes was synthesized from the corresponding diazonium salt and 6-hydroxy-4-phenyl-3-cyano-2-pyridone using a classical reaction for the synthesis of the azo compounds.
Alimmari Adel, Mijin Dušan, Vukićević Radovan, Božić Bojan, Valentić Nataša, Vitnik Vesna, Vitnik Željko, Ušćumlić Gordana   +7 more
doaj   +1 more source