Results 201 to 210 of about 11,648,543 (253)

Efficient one-pot radiosynthesis of the ¹¹C-labeled aquaporin-4 inhibitor TGN-020. [PDF]

EJNMMI Radiopharm Chem
Kawamura K, Kumata K, Yamasaki T, Ogawa M, Kurihara Y, Nengaki N, Nakamura Y, Ono M, Takado Y, Igarashi H, Zhang MR.   +10 more
europepmc   +1 more source

PIEZO1 mechanical insensitivity in generalized lymphatic dysplasia with the potential for pharmacological rescue. [PDF]

iScience
Ludlow MJ, Povstyan OV, Linley DM, Martin-Almedina S, Revill C, Cuthbertson K, Smith KA, Fay E, Fotiou E, Bush A, Hogg C, Linden T, Tan NB, White SM, Del Rey Jimenez JC, Sackey E, Dempsey E, Mansour S, Parsonage G, Kalli AC, Foster R, Ostergaard P, Beech DJ.   +22 more
europepmc   +1 more source

Novel furo[2,3-<i>d</i>]pyrimidine derivatives as PI3K/AKT dual inhibitors: design, synthesis, biological evaluation, and molecular dynamics simulation. [PDF]

RSC Med Chem
Reheim MAMA, Elgammal WE, Bashandy MS, Hamed MIA, AboulMagd AM, Khalil MG, Abdou AM, Hassan RA.   +7 more
europepmc   +1 more source

Bromo-Heptahelicene-Bis-Thiadiazole: Photophysics, Chiroptics, and Excited-State Dynamics. [PDF]

Chemphyschem
Kundu D, Chowdhury R, Del Rio N, Cordier M, Vanthuyne N, Friend RH, Srebro-Hooper M, Crassous J.   +7 more
europepmc   +1 more source

Alkoxy-Substituted Anthrabis(Thiadiazole)-Terthiophene Copolymers for Organic Photovoltaics: A Unique Wavy Backbone Enhances Aggregation, Molecular Order, and Device Efficiency. [PDF]

Chem Asian J
Yan Y, Mori H, Yoshino T, Inami R, Chang J, Gao J, Nishihara Y.   +6 more
europepmc   +1 more source

Overcoming the undruggable barrier: Structure-guided discovery of a potent small molecule CD28 antagonist with translational potential. [PDF]

Biomed Pharmacother
Upadhyay S, Nada H, Cho S, Gabr MT.
europepmc   +1 more source

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Synthesis and Evaluation of Imidazole Derivatives Bearing Imidazo[2,1,b] [1,3,4]thiadiazole Moiety as Antibacterial Agents.

Medicinal chemistry, 2023
BACKGROUND Drug-resistant infections kill hundreds of thousands of people globally every year. In previous work, we found that tri-methoxy- and pyridine-substituted imidazoles show strong antibacterial activities.
Wenhui Xu, Siqi Li, Chang-Ji Zheng, Yu-Xuan Yang, Changhao Zhang, C. Jin   +5 more
semanticscholar   +1 more source

Synthesis, X-ray Crystal Structure, and Antimicrobial Studies of New Quinazolin-4(3H)-one Derivatives Containing the 1,2,4-Triazolo[3,4-b][1,3,4]thiadiazole Moiety and 4-Piperidinyl Linker.

Journal of Agricultural and Food Chemistry, 2023
A total of 35 new quinazolinone derivatives bearing the 1,2,4-triazolo[3,4-b][1,3,4]thiadiazole scaffold and the 4-piperidinyl linker were designed, prepared, and assessed for their antibacterial and antifungal activities.
Nan Wu, Yehui Yang, Guangmin Tian, Lian An, Songsong Liu, Taisen Yan, Mingyan Yi, Xiaoping Bao   +7 more
semanticscholar   +1 more source

Inhibition of α-glucosidase enzyme by 'click'-inspired pharmacophore framework 1,3,4-thiadiazole-1,2,3-triazole hybrids.

Future Medicinal Chemistry, 2023
Aim: α-Glucosidase inhibitors are important oral antidiabetic drugs that are used alone or in combination therapy. Materials & methods: In this regard, 1,3,4-thiadiazoles-1,2,3-triazoles were designed, synthesized and evaluated for α-glucosidase enzyme ...
Manoj Dhameja, H. Kumar, Sirisha Kurella, Ravindra Singh, Adepally Uma, Preeti Gupta   +5 more
semanticscholar   +1 more source