Results 31 to 40 of about 11,648,543 (253)

Quantitative assessment of the nature of noncovalent interactions in N-substituted-5-(adamantan-1-yl)-1,3,4-thiadiazole-2-amines: insights from crystallographic and QTAIM analysis

RSC Advances, 2020
Three adamantane-1,3,4-thiadiazole hybrid derivatives namely; N-ethyl-5-(adamantan-1-yl)-1,3,4-thiadiazole-2-amine I, N-(4-fluorophenyl)-5-(adamantan-1-yl)-1,3,4-thiadiazole-2-amine II and (4-bromophenyl)-5-(adamantan-1-yl)-N-1,3,4-thiadiazole-2-amine ...
A. El-Emam, Elangovan Saveeth Kumar, Krishnakumar Janani, -. LamyaH.Al, Wahaibi, O. Blacque, M. El-Awady, N. H. Al-Shaalan, M. Judith, Percino, S. Thamotharan   +10 more
semanticscholar   +1 more source

Synthesis of new thiophene derivatives and their use as photostabilizers for rigid poly(vinyl chloride) [PDF]

, 2015
Five new thiophenes, namely, N-[(3-bromo-2-methylthiophen-5-yl)methylene]-4-methoxyaniline (4a), N-[(3-bromo-2-methylthiophen-5-yl)methylene]-3,4-dimethoxyaniline (4b), N-[(3-bromo-2-methylthiophen-5-yl)methylene]-3,4-dimethylaniline (4c), 3-[(3-bromo-2 ...
Ahmed, Ahmed, Balakit, Asim A., El-Hiti, Gamal A., Smith, Keith, Yousif, Emad   +4 more
core   +3 more sources

Synthesis and Regioselective Reaction of Some Unsymmetrical Heterocyclic Chalcone Derivatives and Spiro Heterocyclic Compounds as Antibacterial Agents

Molecules, 2015
A number of novel heterocyclic chalcone derivatives can be synthesized by thermal and microwave tools. Treatment of 4-(4-Acetylamino- and/or 4-bromo-phenyl)-4-oxobut-2-enoic acids with hydrogen peroxide in alkaline medium were afforded oxirane ...
Maher A. El-Hashash, Sameh A. Rizk, Saad R. Atta-Allah   +2 more
doaj   +1 more source

Synthesis and crystal structure analysis of 2-​(4-​fluorobenzyl)​-​6-​phenylimidazo[2,​1-​b]​- [1,​3,​4]​thiadiazole and its chlorophenyl derivative [PDF]

, 2014
Prepns. of 2-​(4-​fluorobenzyl)​-​6-​phenylimidazo[2,​1-​b]​[1,​3,​4]​thiadiazole and its chlorophenyl deriv. were described. Preliminary anal. was done spectroscopically by means of 1H NMR, 13C NMR spectra, mass spectra and elemental analyses. Further
Afshan Banu, ., Khazi, I.A.M., Noor Shahina Begum, ., Ravi, S. Lamani   +3 more
core   +1 more source

A comparison between observed and DFT calculations on structure of 5-(4-chlorophenyl)-2-amino-1,3,4-thiadiazole

Scientific Reports, 2019
The crystal and molecular structure of 5-(4-chlorophenyl)-2-amino-1,3,4-thiadiazole 3 was reported, which was characterized by various spectroscopic techniques (FT-IR, NMR and HRMS) and single-crystal X-ray diffraction. The crystal structure 3 (C8H6ClN3S)
Nagaraju Kerru, Lalitha Gummidi, S. V. Bhaskaruni, S. Maddila, Parvesh Singh, S. Jonnalagadda   +5 more
semanticscholar   +1 more source

Targeting the Membrane‐Embedded Rhomboid Protease GlpG: A Multimodal Strategy for Inhibitor Discovery and Mechanistic Insight

Angewandte Chemie, EarlyView.
Created in BioRender. Bohg, C. (2026) https://BioRender.Com/ vi9hi4f. Rhomboid proteases are a mechanistically unique and evolutionarily conserved protein family. Despite their pharmacological relevance, the development of selective inhibitors has lagged behind that of soluble proteases.
Claudia Bohg, Yurii Dubanych, Spyridon Kosteletos, Taoran Xiao, Martin Neuenschwander, Tillmann Utesch, Michael Lisurek, Carl Öster, Andreas Oder, Carola Seyffarth, Kathrin Bach, Denise‐Liù Gracias Leone, František Filandr, Marc Wegert, Sascha Lange, Henry Sawczyc, Jens Peter von Kries, Christian P. R. Hackenberger, Edgar Specker, Han Sun, Kvido Stříšovský, Adam Lange   +21 more
wiley   +2 more sources

Hybrids of Thiazolidin-4-Ones and 1,3,4-Thiadiazole: Synthesis and Biological Screening of A Potential New Class of Acetylcholinesterae Inhibitors

Biointerface Research in Applied Chemistry, 2021
Using propanoic acid and thiosemicarbazide as starting materials, a new sequence of thiazolidin-4-one analogs with thiadiazole derivative was synthesized in appreciable yield.
Navidha Aggarwal, Sandeep Jain, Neetu Chopra   +2 more
semanticscholar   +1 more source

Tetraaza[7]–[15]helicenes Synthesized by Two‐Step Strategy: Length‐Controlled Chiral π‐Systems Exhibiting Amplified Circularly Polarized Luminescence

Angewandte Chemie, EarlyView.
A modular two‐step strategy provides tetraaza[n]helicenes (n = 7–15) as a homologous series with tunable photophysical and chiroptical properties. Extension beyond n = 11 induces pronounced through‐space π–π interactions, narrowing the energy gap and amplifying circularly polarized luminescence.
Takashi Otani, Yuchen Wu, Kohei Ueda, Yuki Ikeda, Yuna Tada, Natsuna Kinoshita, Takanori Shibata   +6 more
wiley   +2 more sources

Unusual anti-leukemia activity of nanoformulated naproxen and other non-steroidal anti-inflammatory drugs [PDF]

, 2016
The non-steroidal anti-inflammatory drugs (NSAIDs) are the most widely used pharmaceuticals worldwide. Interestingly, many of them have significant anticancer properties too.
Aboul-Fadl, Adibkia, Adibkia, Baines, Beetge, Bonelli, Caron, Chen, Conte, Correia, Da Silveira, Dalvi, Davis, Deb, Dhumal, Dixit, Dou, Farideh Javid, Ferreira, Fryer, Gangwar, Guo, Gupta, Harris, Hashitani, Jadhav, Kadajji, Kesisoglou, Kheradmandnia, Khwaja, Kim, Kipp, Kocbek, Kumar, Kumar, Kumar, Lee, Levesque, Li, Liu, Lubet, Lukyanov, Mann, Marques, Merisko-Liversidge, Mizushima, Motawi, Pace, Patil, Plakkot, Plano, Prem Felix Siril, Rainsford, Raj Kumar, Rodríguez, Schreinemachers, Shah, Shaik, Sharma, Shete, Singh, Sinha, Skehan, Sondhi, Srinivas, Szkudliński, Terzioglu, Thun, ul-haq, Van Tomme, Van Tulder, Venkatesan, Verma, Verma, Vichai, Wan, Yu   +76 more
core   +1 more source

Synthesis, Spectroscopic Studies and Keto-Enol Tautomerism of Novel 1,3,4-Thiadiazole Derivative Containing 3-Mercaptobutan-2-one and Quinazolin-4-one Moieties

Molecules, 2020
In this study, a novel 1,3,4-thiadiazole derivative containing 3-mercaptobutan-2-one and quinazolin-4-one moieties (Compound 3) is synthesized by the coupling of 2-amino-1,3,4-thiadiazole-5-(3-mercaptobutan-2-one) (Compound 1) with 2-Phenyl-4H-3,1 ...
Sewara J. Mohammed, A. Salih, M. A. Rashid, K. M. Omer, Karzan A. Abdalkarim   +4 more
semanticscholar   +1 more source