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4-Thiadiazole: The Biological Activities
Systematic Reviews in Pharmacy, 20184-Thiadiazole (1,3,4-thiadiazole) nucleus displayed noteworthy industrial efficiencies and has shown various biological activities, especially as a cancer chemo preventive agent. 4-Thiadiazole has been categorized as a member of family of azole that consist of thiadiazole ring.
Hiba Ibraheem +2 more
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Some biochemical effects of 2-ethylamino-1, 3, 4-thiadiazole
Biochemical Pharmacology, 1959Abstract It has previously been demonstrated (Kaplan et a 4 ), that the injection of large doses of nicotinamide results in a ten-fold increase in the diphosphopyridine nucleotide (DPN) content of the liver of mice. The current report shows that the nicotinamide antagonist 2-ethylamino-1,3,4-thiadiazole (EAT) does not behave as a competitive ...
Louis Shuster, Abraham Goldin
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Microwave Assisted Synthesis and Antibacterial Evaluation of 1, 3, 4-Thiadiazole Derivatives
Research Journal of Pharmacy and Technology, 20211,3,4-Thiadiazole is an important heterocyclic moiety, forms an integral core structural component of different categories of drugs such as antimicrobial, antitubercular, anti-inflammatory, antiepileptic, antiviral, antineoplastics, and analgesic agents. It is a key moiety in current discovery and designing of new drugs.
Jayalakshmi P M +2 more
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Synthesis and Antimicrobial activity of Piperazine analogues containing [1, 3, 4] Thiadiazole ring
Research Journal of Pharmacy and Technology, 2021A new series of piperazine-1, 3, 4-thiadiazole has been synthesized, purified and characterized with the help of their analytical and spectral data. Structures of the synthesized compounds were confirmed by IR, 1H NMR and mass spectroscopy. The potential antimicrobial effects of the synthesized compounds were investigated using Vibrio cholera and ...
Kottakki Naveen Kumar +2 more
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PSEUDOTETRAHEDRAL COBALT(II)-COMPLEXES OF 2, 5-DIMETHYL-1, 3, 4-THIADIAZOLE
Journal of Coordination Chemistry, 1979Abstract The cobalt(II) complexes of 2, 5-dimethyl-1, 3, 4-thiadiazole (DTZ) Co(DTZ)2 X2 (X=Cl, Br, I, NO3) have been prepared and investigated. Their observed magnetic moments lie in the range 4.4–4.6 B.M. The complexes have a pseudo-tetrahedral coordination; a threefold splitting of the electronic v 2 and v 3 bands of the halide complexes indicate a ...
A. C. Fabretti +2 more
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Synthesis and biological evaluation of 5-fatty-acylamido-1, 3, 4-thiadiazole-2-thioglycosides
Bioorganic & Medicinal Chemistry Letters, 2017In the present study, the synthesis of 1, 3, 4-thiadiazole-based thioglycosides were accomplished in good yields with employing a convergent synthetic route. The starting material 5-amino-1, 3, 4-thiadiazole-2-thiol and followed by a series of 5-fatty-acylamido-1, 3, 4-thiadiazole-2-thiols (4a-4j) were synthesized with different fatty acid chlorides ...
Srikanth, Vudhgiri +5 more
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Australian Journal of Chemistry, 1985
A series of mono- and bis -(5'-substituted 1',3',4'-thiadiazol-2'- yl )pyridines with strongly basic side chains, e.g., 3,5-bis[5'(2'-N,N- dimethylaminoethylthio )-1',3',4'-thiadiazol-2'-yl]pyridine (1), and (5?-substituted 1',3',4'-thiadiazol-2'-ylmethyl)pyridines have been prepared for evaluation as amplifiers of phleomycin.
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A series of mono- and bis -(5'-substituted 1',3',4'-thiadiazol-2'- yl )pyridines with strongly basic side chains, e.g., 3,5-bis[5'(2'-N,N- dimethylaminoethylthio )-1',3',4'-thiadiazol-2'-yl]pyridine (1), and (5?-substituted 1',3',4'-thiadiazol-2'-ylmethyl)pyridines have been prepared for evaluation as amplifiers of phleomycin.
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[Synthesis and antimycotic activity of derivatives of 1, 3, 4-thiadiazole (3,2a) pyrimidone].
Il Farmaco; edizione scientifica, 1981As a continuation of previous research designed to obtain derivatives of 1,3,4-thiadiazole of pharmacological interest, some derivatives of 1,3,4-thiadiazole[3,2-alpha]pyrimidin-5-one and isomeric 7-one were prepared. The fungistatic activity of the products was tested in vitro against the following: Candida albicans, Candida parapsilosis, Candida ...
Russo F +3 more
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Research Journal of Pharmacy and Technology, 2018
In this work, thiadiazole derivatives were prepared by taking advantage of active sites in (2-amino-5-mercapto-1,3,4-thiadiazole) as base. The main hetrocyclic compounds (1,3,4-thiadiazole, oxazole) etc. 2-amino-5-mercapto-1,3,4-thiadiazole compound [1] was prepared by cyclic closure of thiosemicarbazide compound with anhydrous sodium carbonate and ...
Shetha. F. Al-Zubiady +2 more
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In this work, thiadiazole derivatives were prepared by taking advantage of active sites in (2-amino-5-mercapto-1,3,4-thiadiazole) as base. The main hetrocyclic compounds (1,3,4-thiadiazole, oxazole) etc. 2-amino-5-mercapto-1,3,4-thiadiazole compound [1] was prepared by cyclic closure of thiosemicarbazide compound with anhydrous sodium carbonate and ...
Shetha. F. Al-Zubiady +2 more
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Synthesis, characterization and biological activity of some 1, 3, 4-thiadiazol derivatives.
Pakistan journal of pharmaceutical sciences, 2012Thiadiazoles are their derivatives exhibit a wide variety of pharmacological activities such as Antibacterial and anti-inflammatory. In the present study we have synthesized derivatives some 2,5 substituted 1,3,4- thiadiazoles. The structures of these synthesized compounds were confirmed by IR, NMR, and MASS spectra data. These compounds were evaluated
Arvind Kumar, Singh +2 more
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