Synthesis and biological evaluation of selective phosphonate-bearing 1,2,3-triazole-linked sialyltransferase inhibitors [PDF]
, 2021 The critical role of sialyltransferase (ST) enzymes in tumour cell growth and metastasis, as well as links to multi-drug and radiation resistance, has seen STs emerge as a target for potential antimetastatic cancer treatments.
Andrew P Montgomery (20254962) +4 more
core
Toward Chromoselective Transformations in Biological Systems: Perspectives and Challenges
Angewandte Chemie International Edition, EarlyView.Controlling biological systems with small‐molecule chromophores has evolved into a powerful strategy and is applied from chemical biology to medicine. However, the complexity of in vivo systems cannot be matched by a single wavelength of light. Developing methods to combine and individually control multiple chromophores is crucial.
Nadja A. Simeth
wiley +1 more source
Synthesis, Crystal Structure, EXAFS, and Magnetic Properties of catena-Poly[μ-tris(4-(2-hydroxyethyl)-1,2,4-triazole-N1,N2)copper(II)] Diperchlorate Trihydrate: Relevance with the Structure of the Iron(II) 1,2,4-Triazole Spin Transition Molecular Materials [PDF]
, 2016 [Cu(hyetrz)3](ClO4)2·3H2O (hyetrz = 4-(2-hydroxyethyl)-1,2,4-triazole) represents the first structurally characterized metal(II) chain compound containing triple N1,N2-1,2,4-triazole bridges. The structure has been solved at 298 K by single-crystal X-ray
Yann Garcia (1727962) +9 more
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Zaporožskij Medicinskij Žurnal, 2017 Over the past decade the number of publications, that contain different aspects of chemistry and use of triazoles and tetrazoles have been doubled and continues to grow. Puplications of recent years show that heterocycles with 1,2,3,4-teterazoles and 1,2,
Yu. S. Hulina, A. G. Kaplaushenko
doaj +1 more source
The Synthesis, Antimicrobial Activity, and Molecular Docking of New 1, 2, 4-Triazole, 1, 2, 4-Triazepine, Quinoline, and Pyrimidine Scaffolds Condensed to Naturally Occurring Furochromones. [PDF]
Pharmaceuticals (Basel), 2022 Abu-Hashem AA, Al-Hussain SA.
europepmc +1 more source
Synthesis and cytotoxic activity evaluation of some new 1, 3, 4-oxadiazole, 1, 3, 4-thiadiazole and 1, 2, 4- triazole derivatives attached to phthalimide. [PDF]
Res Pharm Sci, 2021 Hassanzadeh F +3 more
europepmc +1 more source
Late‐Stage Functionalization of Peptides on the Solid Phase
Angewandte Chemie International Edition, EarlyView.Peptide modifications are essential to control pharmacodynamic and pharmacokinetic properties of peptide drugs. Consequently, strategies that allow for efficient and rapid incorporation of non‐canonical modifications into peptides in parallel formats are highly sought after.
Marius Werner +2 more
wiley +1 more source
LiquidsNew experimental vapour pressures and vaporisation enthalpies of the ionic liquids [2,4-dimethyl-1,2,4-triazolium][NTf2], [2-methyl-4-ethyl-1,2,4-triazolium][NTf2], and [2-ethyl-4-methyl-1,2,4-triazolium][NTf2] were measured using the Langmuir method in ...
Sergey P. Verevkin, Dzmitry H. Zaitsau
doaj +1 more source
1-(4-chlorophenyl)triazole [PDF]
, 2019 This dataset contains experimental data from a sample (1-(4-chlorophenyl)triazole, InChI=1S/C8H6ClN3/c9-7-1-3-8(4-2-7)12-6-5-10-11-12/h1-6H). The datasets from the following experiments are available: infrared absorption spectroscopy (
Huang, Yu-Chieh
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Aktualʹnì Pitannâ Farmacevtičnoï ì Medičnoï Nauki ta Praktiki, 2015 Aim. We have continued the study of 1,2,4-triazole derivatives, which contain 2-, 3- , 4-methoxyphenyl or 3,4,5- methoxyphenyl substituents in 5th position of the triazole nucleus.
Yu. G. Samelyuk , A. G. Kaplaushenko
doaj +1 more source