Results 131 to 140 of about 45,597 (250)

Cysteine Peptidases in Antitumor Immunity: Unraveling Antigen‐Presenting Cell Regulation and Therapeutic Potential

iMetaMed, EarlyView.
This review systematically summarizes the central role of cysteine peptidases in modulating antigen‐presenting cell (APC) function and antitumor immune responses, highlighting their critical significance in overcoming tumor immune evasion. Current research has established that cysteine peptidase subtypes, including cathepsins B, S, L, and X, exert ...
Yimao Wu, Xiaoyan Chen, Zichang Chen, Yalun Liang, Gokhan Zengin, Qian Zhang, Wenlong Sun, Meng‐Yao Li   +7 more
wiley   +1 more source

Biological and In Silico Evaluation of Novel Methoxyphenol-1,2,3-Triazole Hybrids as Multifunctional Anti-Alzheimer's and Anticancer Agents. [PDF]

Chem Biol Drug Des
Onur S, Çeşme M, Tümer F.
europepmc   +1 more source

Evaluation of DNA/Chromosome Integrity and Cell Death in Human Metabolically Noncompetent and Competent Cells Exposed to N′‐(3,5‐Difluorobenzylidene)Pyridine‐4‐Carbohydrazide

Journal of Applied Toxicology, EarlyView.
ABSTRACT The N‐acylhydrazone scaffold is recognized as a privileged structure for the design of bioactive substances with increasing applications in medicinal chemistry research. Ensuring the safety of newly developed molecules is a critical step for both human health and environmental protection. Accordingly, this study aimed to evaluate the cytotoxic
Larissa Ribeiro Canuto Santos, Jéssica Natalia Barbosa de Almeida, Camila Cavalleiro Frias, Wanda Pereira Almeida, Edson Luis Maistro   +4 more
wiley   +1 more source

Fungicidal Activity and In Silico Studies of Triazoles Derived From Glycerol Against Neocosmospora falciformis, A Causal Agent of Guava Tree Decline. [PDF]

Chem Biodivers
Costa AV, Correia AO, Benvindo Dos Anjos B, de Oliveira MB, Gazolla PAR, de Queiroz VT, Resende JA, Teixeira RR, de Oliveira OV, Vargas GJ, Júnior WCJ, Moraes WB, Alves FR.   +12 more
europepmc   +1 more source

Bee pollen as functional food and environmental bioindicator: current evidence and future challenges

Journal of the Science of Food and Agriculture, EarlyView.
Abstract Bee pollen (BP), a plant‐derived product collected by honey bees, is increasingly promoted as a functional food due to its content of proteins, essential amino acids, lipids, vitamins, minerals, and bioactive compounds such as polyphenols and flavonoids.
Luigi Parrotta, Stefano Del Duca
wiley   +1 more source

Triazole-Functionalized Jatrophone Derivatives as Antiprotozoal Agents Against <i>Trypanosoma cruzi</i>: Synthesis, Biological Evaluation and Structure-Activity Relationships. [PDF]

Pharmaceuticals (Basel)
Pertino MW, Carreño Gonzalez P, Venegas González C, Schmeda-Hirschmann G, Vega Gómez C, Rolón M, Rojas de Arias A.   +6 more
europepmc   +1 more source

Corrosion‐Protection of T122 Steel Using g‐C3N5‐Embedded Epoxy Coatings

Materials and Corrosion, EarlyView.
Study evaluates g‐C3N5 (CN) reinforced epoxy coatings on T122 steel in NaCl and H2SO4. Electrochemical tests revealed that 2% loading maximizes corrosion resistance by blocking pores and limiting ion diffusion, increasing Rp and Rn. Optimized CN content enhances epoxy coating performance overall system durability material. ABSTRACT Corrosion‐protection
Martha Patricia Hernández‐Valencia, Tathagata Kar, Maura Casales‐Díaz, José Juan Ramos‐Hernández, América María Ramírez‐Arteaga, José Gonzalo González‐Rodríguez, Roy López‐Sesenes, Mohan Kumar Kesarla   +7 more
wiley   +1 more source

Diversity and Multi-Target Potential of Pyrazole, Imidazole or Triazole Derivatives in Modern Anticancer Therapy. [PDF]

Int J Mol Sci
Mysłek M, Kaczmarek A, Świątek P, Czyżnikowska Ż.   +3 more
europepmc   +1 more source

Hydroxamic Acids as HDAC Inhibitor Drug Leads for Malaria

Medicinal Research Reviews, EarlyView.
ABSTRACT Malaria is a global health threat, with an estimated 282 million cases and 610,000 malaria‐associated deaths reported in 2024. Most mortality is due to infection by Plasmodium falciparum parasites, with the highest burden occurring in Sub‐Saharan Africa.
Wisam A. Dawood, Jacinta R. Macdonald, Christian Anzenhofer, Tina S. Skinner‐Adams, Robert C. Reid, Thomas Kurz, David P. Fairlie, Katherine T. Andrews   +7 more
wiley   +1 more source

Imaging of Fibroblast Activation Protein in the Microenvironment of Tumors by ¹⁸F‑Labeled Positron Emission Tomography Tracers with Increased Polarity. [PDF]

ACS Pharmacol Transl Sci
Köchel R, Wagner S, Breyholz HJ, Schäfers M, Schwegmann K, Wünsch B.   +5 more
europepmc   +1 more source