Results 141 to 150 of about 46,073 (280)

Evaluation of DNA/Chromosome Integrity and Cell Death in Human Metabolically Noncompetent and Competent Cells Exposed to N′‐(3,5‐Difluorobenzylidene)Pyridine‐4‐Carbohydrazide

Journal of Applied Toxicology, EarlyView.
ABSTRACT The N‐acylhydrazone scaffold is recognized as a privileged structure for the design of bioactive substances with increasing applications in medicinal chemistry research. Ensuring the safety of newly developed molecules is a critical step for both human health and environmental protection. Accordingly, this study aimed to evaluate the cytotoxic
Larissa Ribeiro Canuto Santos, Jéssica Natalia Barbosa de Almeida, Camila Cavalleiro Frias, Wanda Pereira Almeida, Edson Luis Maistro   +4 more
wiley   +1 more source

A personal 360° view of applications of ‘biomimetic’ molecular recognition

Journal of Chemical Technology &Biotechnology, EarlyView.
Abstract Molecular recognition between biological molecules has formed the basis for innumerable applications in biotechnology for the last seven decades or so. Techniques such as affinity chromatography, solid‐phase and aqueous two‐phase extraction, affinity precipitation, biomimetic catalytic systems, biosensors and molecular imprinting all exploit ...
Christopher R Lowe
wiley   +1 more source

Evaluation of antifungal and antimycotoxigenic activity of selected natural antioxidants against Fusarium culmorum: in vitro and in planta assays

Journal of the Science of Food and Agriculture, EarlyView.
Abstract BACKGROUND Fusarium culmorum causes Fusarium head blight (FHB) in cereals, leading to significant yield losses and contamination with type B trichothecene mycotoxins such as deoxynivalenol (DON) and its acetylated derivatives 3‐ADON and 15‐ADON.
Safa Oufensou, Davide Fabbri, Maria Antonietta Dettori, Paola Carta, Emanuela Azara, Valeria Ugone, Virgilio Balmas, Ismael Malbrán, Quirico Migheli   +8 more
wiley   +1 more source

Diacetylene‐Functionalized Glycan Mimetics for Receptor‐Mediated Cluster Imprinting in Model Membranes

Macromolecular Rapid Communications, EarlyView.
Diacetylene‐containing glycan mimetics cluster upon selective lectin binding in GUVs. Subsequent irradiation leads to the formation of fluorescent polymer clusters, while non‐clustered glycan mimetics remain unaffected in the membrane. ABSTRACT The glycocalyx, a dense layer of glycoproteins and glycolipids on eukaryotic cells, is essential for cellular
Luca‐Cesare Blawitzki, Lina Charlotte Assenmacher, Nicholas Jäck, Stephan Schmidt, Cornelia Monzel, Laura Hartmann   +5 more
wiley   +1 more source

Evaluation of antioxidant activity of 1,2,4-triazole derivatives in the initiation of free radical processes

Aktualʹnì Pitannâ Farmacevtičnoï ì Medičnoï Nauki ta Praktiki
The activation of lipid free radical oxidation is a key stage in the development of many diseases and can lead to the emergence of related complications.
I. M. Bilai, V. I. Dariy, A. V. Khilkovets, A. I. Bilai, I. F. Duiun   +4 more
doaj   +1 more source

Genotoxicity testing of antiparasitic nitrofurans in the Drosophila wing somatic mutation and recombination test [PDF]

, 2017
Nifurtimox and eight structurally related 5-nitrofuran compounds active against Trypanosoma cruzi were tested for genotoxicity in the wing somatic mutation and recombination test in Drosophila melanogaster.
Graf, Ulrich, Moraga, Angeles Alonso
core  

Design, Synthesis, Cytotoxicity Assessment, and Molecular Docking of Novel Triazolopyrimidines as Potent Cyclin‐Dependent Kinase 4 Inhibitors

ChemistryOpen, EarlyView.
A novel series of 1,5‐dihydro‐[1,2,4]triazolo[4,3‐a]pyrimidines (5a–g) is synthesized and evaluated as potential CDK4 inhibitors. Compounds 5c and 5d exhibit strong cytotoxicity toward HepG2 and MCF‐7 cells with IC50 ≈ 1–2 µM, comparable to doxorubicin.
Tariq Z. Abolibda, Sami A. Al‐Hussain, Basant Farag, Mohamed El‐Naggar, Magdi E. A. Zaki, Emad S. A. Alhazmi, Adel S. M. Almohammadi, Sobhi M. Gomha   +7 more
wiley   +1 more source

STUDY OF THE PROTONATION OF 1, 2, 4-TRIAZOLE. DFT CALCULATIONS

Journal of Chemistry and Technologies
У цій роботі досліджена реакція між 1,2,4-тріазолом і хлоридною кислотою (HCl) з метою синтезу протонованого 1,2,4-тріазолу (TAH+). Ми використовували розрахунки теорії функціоналу густини (DFT), щоб отримати уявлення про структурний аналіз молекули. Кілька дескрипторів реакційної здатності, включаючи спорідненість до електрона, різниця енергій HOMO ...
El Addali, Abdelahad, El-Kiri, Zakaryae, El Boukili, Abdellah, Saufi, Hamid, Boudad, Lahcen   +4 more
openaire   +2 more sources

Synthesis of Pyrido[2,3‐d]Azolopyrimidinones: Design and Epidermal Growth Factor Receptor‐Targeted Molecular Docking Toward Novel Anticancer Leads

ChemistryOpen, EarlyView.
New pyrido[2,3‐d]azolopyrimidinones were synthesized and evaluated as potent EGFR‐targeted anticancer leads. Molecular docking and cytotoxicity studies revealed strong receptor binding and submicromolar activity, highlighting this scaffold as a promising framework for future targeted drug development.
Sobhi M. Gomha, Sami A. Al‐Hussain, Basant Farag, AbdElAziz A. Nayl, Wesam Hussein, Abdelwahed R. Sayed, Magdi E. A. Zaki   +6 more
wiley   +1 more source

Diverse reactivity of maleimides in polymer science and beyond

Polymer International, Volume 74, Issue 4, Page 296-306, April 2025.
This mini‐review provides a thorough overview of maleimide chemistry, highlighting its diverse reactivity in polymer and materials science applications. Abstract Maleimides are remarkably versatile functional groups, capable of participating in homo‐ and copolymerizations, Diels–Alder and (photo)cycloadditions, Michael additions, and other reactions ...
Bruce E Kirkpatrick, Kristi S Anseth, Tayler S Hebner   +2 more
wiley   +1 more source