Results 91 to 100 of about 155,151 (257)

Enzymatic Basis for the Oxidative Branch of Aromatic Amino Acid Fermentation Leading to p‐cresol Formation

Advanced Science, EarlyView.
In anaerobic bacteria, tyrosine serves as an electron donor in the oxidative Stickland fermentation branch, generating p‐hydroxyphenylacetate, ATP and reduced ferredoxin for decarboxylation into p‐cresol. ABSTRACT The phenolic metabolite p‐cresol is a byproduct of tyrosine fermentation by certain strictly anaerobic bacteria, including the human gut ...
Li Jiang, Yifeng Wei, Xumei Liu, Dazhi Liu, Zhenyu Liu, Yang Tong, Jinyu Yin, Ankanahalli N. Nanjaraj Urs, Meining Xing, Mark A. Harrison, Chuyuan Zhang, Sheng Yang, Yunzi Luo, Ee Lui Ang, Huimin Zhao, Yan Zhang   +15 more
wiley   +1 more source

Genetic and metabolic engineering approaches for enhanced biodesulfurization of petroleum fractions

Frontiers in Bioengineering and Biotechnology
Sulfur, an abundant component of crude oil, causes severe damage to the environment, poses risks to human health, and poisons the catalysts used in combustion engines.
Asheemita Bagchi, Preeti Srivastava
doaj   +1 more source

Substrate‐Affinitive P‐Type Azapolycyclic Photosensitizer for Chemoselective Nitrilization Under Mild Conditions

Advanced Science, EarlyView.
We developed a series of quinoxalinoquinoxaline (QQ) photosensitizers featuring high and tunable excited‐state reduction potentials (E(PC•+/PC*) = –1.76 to –2.05 V vs. SCE). Their hydrogen‐bonding interaction with carbonyl substrates enables selective single‐electron transfer events for selective nitrilization of 1° amides, offering a tunable ...
Seongwoo Bae, Dongwook Kim, Jinwoo Kim
wiley   +1 more source

Hyperlipidemia Aggravates Alveolar Bone Loss via Periodontal Ligament Stem Cell Ferroptosis Through GSK3β Dependent Ubiquitin‐Mediated NRF2 Degradation

Advanced Science, EarlyView.
Lipid metabolic stress triggers ferroptosis in PDLSCs through the GSK3β/NRF2 pathway, thereby aggravating periodontal bone loss. Upregulated GSK3β promotes NRF2 ubiquitination and proteasomal degradation via β‐TrCP, suppressing NRF2 nuclear translocation and antioxidant target expression.
Yuxiao Zhang, Xiangyao Wang, Yaxin Wu, Liping Liu, Gaoshaer Nuerlan, Ahsawle Ozathaley, Xiaorui Zhang, Jinping Wang, Bowen Yang, Jing Mao, Yan Liu, Shiqiang Gong   +11 more
wiley   +1 more source

ACLY‐Driven Metabolic Reprogramming Promotes Histone Acetylation and Inflammation‐Associated Fibrosis in Chronic Kidney Disease

Advanced Science, EarlyView.
This study reveals a citrate–ACLY–H3K27ac metabolic–epigenetic axis driving inflammatory gene activation and kidney fibrosis, highlighting ACLY inhibition as a potential therapeutic strategy for chronic kidney disease (CKD). ABSTRACT The mechanisms by which metabolic stress drives epigenetic dysregulation and fibrosis in chronic kidney disease (CKD ...
Chunxiu Du, Dhanunjay Mukhi, Lingzhi Li, Chenyu Li, Siyu Pan, Bernhard Dumoulin, Eunji Ha, Lakshmi P Kolligundla, Yanjuan Hou, Jonathan Levinsohn, Chaelin Kang, Konstantin Adrian Klötzer, Junnan Wu, Samer Mohandes, Kathryn E Wellen, Katalin Susztak   +15 more
wiley   +1 more source

Studies on the Preparation of Protomycinolide IV: Enantioselective Synthesis of the C3–C9 Segment [PDF]

, 1998
The C3–C9 segment, (−)-16, of the polyene macrolide antibiotic protomycinolide IV (1a) was prepared in optically pure form from commercially available methyl (S)-2-methyl-3-hydroxypropionate in 12 steps giving 17 ...
Donaldson, William, Wasicak, James Thomas   +1 more
core   +1 more source

Coherent strong-field control of multiple states by a single chirped femtosecond laser pulse

, 2011
We present a joint experimental and theoretical study on strong-field photo-ionization of sodium atoms using chirped femtosecond laser pulses. By tuning the chirp parameter, selectivity among the population in the highly excited states 5p, 6p, 7p and 5f,
, Baumert T, Bayer T, Brixner T, Brundobler S, C Sarpe-Tudoran, Carroll C E, Carroll C E, Fielding H, M Krug, M Wollenhaupt, N V Vitanov, Nürnberger P, Ostrovsky V N, Rice S, S S Ivanov, Seaton M J, Shapiro M, Shore B W, Shore B W, T Baumert, T Bayer, Tannor D, Whitaker B, Wollenhaupt M, Wollenhaupt M, Wollenhaupt M   +26 more
core   +1 more source

Organic Thin‐Film Transistors for Neuromorphic Computing

Advanced Electronic Materials, EarlyView.
Organic thin‐film transistors (OTFTs) are reviewed for neuromorphic computing applications, highlighting their power‐efficient, and biological time‐scale operation. This article surveys OFET and OECT devices, compares them with memristors and CMOS, analyzes how fabrication parameters shape spike‐based metrics, proposes standardized characterization ...
Luke McCarthy, Mohan V. Jacob, Mostafa Rahimi Azghadi   +2 more
wiley   +1 more source

Integrated Omics Approaches to Explore a New System of Genetic Control of Dibenzothiophene Desulfurization and Aromatic Ring Cleavage by Gordonia alkanivorans Strain 135

Biology
Dibenzothiophene (DBT) is a widespread environmental pollutant. The most common metabolic pathway for DBT degradation by Gordonia strains is the 4S pathway, which is under the control of the dsz operon.
Ekaterina Frantsuzova, Alexander Bogun, Anna Vetrova, Elizaveta Kazakova, Tomiris Kusainova, Irina Tarasova, Irina Pozdnyakova-Filatova, Yanina Delegan   +7 more
doaj   +1 more source

Study of a desulfurization process to convert dibenzothiophene to 2-hydroxybiphenyl by Rhodococcus rhodochrous NRRL (B-2149) [PDF]

, 2007
[Abstract] Actually, a great effort is being given to research on biodesulfurization processes, i.e., processes in which sulfur can be removed selectively from sulfur-compound moities without altering its British thermal unit.
Chagas, Bruna M. E., Domingos, Thyrone B., Gurgel, Yanne K. P., Macedo, Gorete R., Santos, Everaldo S., Soares Júnior, Aldo B.   +5 more
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