Results 81 to 90 of about 155,151 (257)

Cuproptosis and Mitophagy Mediated by the THUMPD1/IGF2R‐Dependent Suppression of AKT and Activation of AMPK Signaling Suppress Lung Adenocarcinoma Progression

Advanced Science, EarlyView.
THUMPD1 drives a tumor‐suppressive signaling cascade in lung adenocarcinoma by promoting IGF2R expression. IGF2R associates with PPP2R1A to suppress AKT and activate AMPK, leading to SLC31A1 upregulation and copper accumulation. Elevated copper disrupts mitochondrial metabolism and induces excessive mitophagy, thereby restraining tumor growth and ...
Kai Wu, Bo Qin, Zhuoyu Gu, Weizheng Ding, Xiaoming Chen, Kaishang Zhang, Yujin Qiao, Shuang Yuan, Song Zhao, Xiangnan Li, Peng Zhang   +10 more
wiley   +1 more source

Enhancement of dibenzothiophene biodesulfurization by weakening the feedback inhibition effects based on a systematic understanding of the biodesulfurization mechanism by Gordonia sp. through the potential “4S” pathway

RSC Advances, 2016
Gordonia sp. JDZX13 (source: industrial petroleum soil) shows good potential for dibenzothiophene (DBT) biodesulfurization.
Shoushuai Feng, Hailin Yang, Xiao Zhan, Wu Wang   +3 more
openaire   +1 more source

Dose‐Dependent Reprogramming of Chromatin Accessibility by SOX4 Drives the Transcriptional Response to Iron Overload

Advanced Science, EarlyView.
This study demonstrates that iron overload triggers widespread chromatin compaction and transcriptional repression in human granulosa cells, recapitulating features of endometriosis. The epigenetic reprogramming is orchestrated by a TFEB‐SOX4‐SWI/SNF axis, with SOX4 acting as a central, dosage‐sensitive regulator.
Feifei Li, Yaoqiu Wu, Guangyu Yang, Jingyi Lai, Xiaoyue Sun, Liyan Wang, Xiaoli Li, Jing Zhang, Qingxue Zhang, Hui Chen, Haiyan Lin, Bingxiang Xu, Junfeng Zhang, Hailong Wang, Anming Meng, Chunwei Cao   +15 more
wiley   +1 more source

Two‐Dimensional Infrared Spectroscopy Reveals the Presence of a Bridging CO Ligand in Two Catalytic Intermediates of [FeFe] Hydrogenase

Angewandte Chemie, EarlyView.
Two‐dimensional (2D) infrared (IR) spectroscopy provides vastly more structural and functional insight into chemical and biological systems than linear IR spectroscopy. Here, we apply 2D‐IR spectroscopy to two controversially discussed states of the [FeFe] hydrogenase active site, revealing the presence of a bridging carbonyl ligand, which is difficult
Cornelius C. M. Bernitzky, Mathesh Vaithiyanathan, Manon T. Lachmann, Igor V. Sazanovich, Gregory M. Greetham, Patricia Rodríguez‐Maciá, James A. Birrell, Marius Horch   +7 more
wiley   +2 more sources

Crystal structure and absolute configuration of (3aS,4S,5R,7aR)-2,2,7-trimethyl-3a,4,5,7a-tetrahydro-1,3-benzodioxole-4,5-diol

Acta Crystallographica Section E: Crystallographic Communications, 2015
The absolute configuration of the title compound, C10H16O4, determined as 3aS,4S,5R,7aR on the basis of the synthetic pathway, was confirmed by X-ray diffraction.
Mario A. Macías, Leopoldo Suescun, Enrique Pandolfi, Valeria Schapiro, Gaurao D. Tibhe, Álvaro W. Mombrú   +5 more
doaj   +1 more source

Belle II early physics program of bottomonium spectroscopy

, 2016
The Belle II experiment at the SuperKEKB collider is a major upgrade of the KEK "$B$ factory" facility in Tsukuba, Japan. Phase 1 commissioning of the main ring of SuperKEKB has started in February 2016 and first physics data will be recorded in 2017 ...
Ye, Hua
core   +1 more source

Comparative analysis of biodesulfurization of dibenzothiophene (DBT) and 4,6-dimethyl dibenzothiophene (4,6-DMDBT) by 4S pathway using molecular simulations

Preparative Biochemistry & Biotechnology
In this paper, we have analyzed biodesulfurization of dibenzothiophene (DBT) and 4,6-dibenzothiophene (4,6-DMDBT) by 4S metabolic pathway using molecular simulations. Docking analysis revealed lower binding energies and inhibition constants (Ki) for 4,6-DMDBT and its metabolic intermediates with DSZ enzymes than DBT and its intermediates. The complexes
Pushpita, Das, , Umesh, Lepakshi, Barbora, Vijayanand Suryakant, Moholkar   +3 more
openaire   +2 more sources

Engineering Approaches to Modify Immunomodulatory Functions of Mesenchymal Stromal Cells (MSCs): Tissue Regeneration and Clinical Application

Advanced Science, EarlyView.
Mesenchymal stromal cells (MSCs) show promise for treating immune‐related disorders through immunomodulation and tissue regeneration. This review gives a brief overview of current clinical approval of MSC therapies. It also discussed how bioengineering, including genetic modification, biomaterial delivery, extracellular vesicles, and iPSC‐derived MSCs,
Sichen Yang, Kejia Li, Ning Wang, Zhen Li, Zhiyong Zhang, Rocky S. Tuan, Yangzi Jiang   +6 more
wiley   +1 more source

Accuracy and applicability of periodontitis risk assessment tools: A critical appraisal

Periodontology 2000, EarlyView., 2023
Abstract Currently, periodontal risk assessment finds application at first visit (to identify individuals at high risk of either disease incidence, if still healthy, or disease progression, if already diseased) as well as at patient monitoring after active treatment and enrolment in a supportive periodontal care program.
Roberto Farina, Rodrigo Lopez, Anna Simonelli, Leonardo Trombelli   +3 more
wiley   +1 more source

Modular Generation of Alkyl Selenyl Radicals for the Synthesis of Alkyl Selenides via a Mechanochemical Approach

Advanced Science, EarlyView.
We present a mechanochemical, radical‐mediated hydroselenation of alkenes under ambient conditions. This method modularly generates alkyl selenyl radicals from elemental selenium and alkyl (pseudo)halides, utilizing PhSiH3 and H2O as hydrogen atom donors, with the water likely originating from the air and/or trace water present in the reagents ...
Xiaochun He, Yu Zhou, Fei Zhou, Zixi Ai, Peiyu Hu, Xuemei Zhang, Xiaofeng Wei, Gui‐Juan Cheng, Zhong Lian   +8 more
wiley   +1 more source