Evolutionary flexibility and rigidity in the bacterial methylerythritol phosphate (MEP) pathway [PDF]
Frontiers in Microbiology, 2023 Terpenoids are a diverse class of compounds with wide-ranging uses including as industrial solvents, pharmaceuticals, and fragrances. Efforts to produce terpenoids sustainably by engineering microbes for fermentation are ongoing, but industrial ...
Bailey Marshall +8 more
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Functional analysis of the methylerythritol phosphate pathway terminal enzymes IspG and IspH from Zymomonas mobilis [PDF]
Microbiology SpectrumIsoprenoids are a diverse family of compounds that are synthesized from two isomeric compounds, isopentenyl diphosphate and dimethylallyl diphosphate. In most bacteria, isoprenoids are produced from the essential methylerythritol phosphate (MEP) pathway.
Jyotsna Misra +2 more
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Molecules, 2022 The non-mevalonate or also called MEP pathway is an essential route for the biosynthesis of isoprenoid precursors in most bacteria and in microorganisms belonging to the Apicomplexa phylum, such as the parasite responsible for malaria.
Myriam Seemann +2 more
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MEP Pathway: First-Synthesized IspH-Directed Prodrugs with Potent Antimycobacterial Activity [PDF]
MicroorganismsWe report the first synthesis of IspH-directed prodrugs targeting the terminal enzyme of the 2-C-methyl-D-erythritol 4-phosphate (MEP) pathway, (E)-4-hydroxy-3-methylbut-2-enyl diphosphate reductase (IspH or LytB).
Alizée Allamand +5 more
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An improved solid boundary treatment for wave–float interactions using ISPH method
International Journal of Naval Architecture and Ocean Engineering, 2018 The Smoothed Particle Hydrodynamics (SPH) method has proved to have great potentials in dealing with the wave-structure interactions. Compared with the Weakly Compressible SPH (WCSPH) method, the ISPH approach solves the pressure by using the pressure ...
Songdong Shao +2 more
exaly +3 more sources
Factors influencing the intention of women with perinatal depression and their spouses to seek professional psychological help: a cross-sectional latent profile analysis [PDF]
Frontiers in Public HealthBackgroundSeeking professional psychological help can improve outcomes for women with perinatal depression (PND). However, the use of professional psychological help-seeking behaviors for women with PND is not promising.
Qinhan Zou +4 more
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Frontiers in Bioengineering and Biotechnology, 2022 (E)-4-hydroxy-3-methylbut-2-enyl pyrophosphate (HMBPP) reductase (IspH) is a [4Fe-4S] cluster-containing enzyme, involved in isoprenoid biosynthesis as the final enzyme of the methylerythritol phosphate (MEP) pathway found in many bacteria and malaria ...
Shiyong Huang +4 more
doaj +1 more source
مدل سازی عددی شکست موج در کانال با مانع با استفاده از روش هیدرودینامیک ذرات هموار شده تراکم ناپذیر [PDF]
علوم و مهندسی آبیاری, 2020 شکست موج پدیدهای است که در جریانهای مخاطرهآمیز سیلاب اتفاق میافتد. از این رو شبیهسازی چنین جریانهایی با روشی مناسب از اهمیت ویژهای برخوردار است.
ساجده فرمانی +2 more
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Harm Reduction Journal, 2020 Aim Evidence is emerging that prescription opioid (PO) injection is associated with increased health risks. This mixed-methods study compares the mechanics of PO and heroin injection and examines the demographic and drug-related correlates of lifetime PO
Pedro Mateu-Gelabert +8 more
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Utilizing a dynamical description of IspH to aid in the development of novel antimicrobial drugs. [PDF]
PLoS Computational Biology, 2013 The nonmevalonate pathway is responsible for isoprenoid production in microbes, including H. pylori, M. tuberculosis and P. falciparum, but is nonexistent in humans, thus providing a desirable route for antibacterial and antimalarial drug discovery.
Patrick G Blachly +3 more
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