Results 11 to 20 of about 1,719 (170)

Eulerian ISPH Method for Simulating Internal Flows

Journal of Applied Fluid Mechanics, 2016
In this article the possibility to use Eulerian approach in the conventional ISPH method in simulation of internal fluid flows is studied. The use of Eulerian approach makes it possible to use non-uniform particle distributions to increase the resolution
Mani Ordoubadi, Asghar Farhadi, Firoozeh Yeganehdoust, Homayoon Emdad, Mahmood Yaghoubi, Ebrahim Goshtasebi Rad   +5 more
doaj   +2 more sources

Resonance Raman Spectroscopic Study of the Unusual [4Fe-4S]²⁺ Cluster of IspH, the Last Enzyme of the Methylerythritol Phosphate Pathway for Terpenoid Biosynthesis. [PDF]

Chembiochem
Raman spectroscopy confirms that the apical Fe atom of the [4Fe‐4S]2+ cluster of IspH is linked to H2O molecules and that the (E)‐4‐hydroxy‐3‐methyl‐but‐2‐en‐1‐yl diphosphate substrate and the propargyl diphosphate inhibitor lead to a change of coordination geometry. The loss of octahedral coordination of the apical Fe atom is also very likely when the
Jobelius H, Chaignon P, Bianchino GI, Wandzig J, Hellwig P, Seemann M, Melin F.   +6 more
europepmc   +2 more sources

Engineering Cyanobacteria for High-Yield Photosynthetic Isoprene Production With Long-Term Phenotypic Stability. [PDF]

Plant Biotechnol J
Center: Cyanobacterial isoprene production from CO2 and sunlight. Top: CRISPR‐editing for generation of markerless production strains. Top right: Long‐term production assay for strain stability assessment. Bottom right: Engineering of MEP pathway and surrounding metabolism for bottleneck idenfication. Bottom left: Relief of bottleneck by overproduction
Janssen KN, Bolay P, Tüllinghoff A, Toepel J, Spindler D, Bühler B, Lindberg P.   +6 more
europepmc   +2 more sources

An efficient, open source, iterative ISPH scheme [PDF]

Computer Physics Communications, 2020
Updated based on reviewer comments and several ...
Abhinav Muta, Prabhu Ramachandran, Pawan Negi   +2 more
openaire   +2 more sources

Bioorganometallic mechanism of action, and inhibition, of IspH [PDF]

Proceedings of the National Academy of Sciences, 2010
We have investigated the mechanism of action of Aquifex aeolicus IspH [E-4-hydroxy-3-methyl-but-2-enyl diphosphate (HMBPP) reductase], together with its inhibition, using a combination of site-directed mutagenesis ( K M
Weixue, Wang, Ke, Wang, Yi-Liang, Liu, Joo-Hwan, No, Jikun, Li, Mark J, Nilges, Eric, Oldfield   +6 more
openaire   +2 more sources

Substitution of CH₃ by CH₂F in 2-Methylerythritol Cyclodiphosphate Triggers Potent Inhibition of IspG with Concomitant Fluoride Ion Expulsion. [PDF]

Chemistry
The fluoromethyl analogue of MEcPP was identified as a very potent inhibitor of the oxygen‐sensitive [4Fe‐4S] metalloenzyme IspG. In the course of the IspG‐catalyzed transformation, this novel compound undergoes fluoride elimination, offering additional evidence for the involvement of a carbanionic intermediate in the mechanism of this enzyme ...
Witjaksono C, Herrscher V, Jobelius H, Noël N, Massicot F, Vasse JL, Behr JB, Seemann M.   +7 more
europepmc   +2 more sources

A maximalist approach to the systematics of a biological control agent: Gryon aetherium Talamas, sp. nov. (Hymenoptera, Scelionidae) [PDF]

Journal of Hymenoptera Research, 2021
A morphological and molecular analysis of Gryon Haliday (Platygastroidea, Scelionidae) was conducted to provide a taxonomic and phylogenetic context for a species under evaluation as a biological control agent of Bagrada hilaris (Burmeister) (Hemiptera ...
Elijah J. Talamas, Jonathan S. Bremer, Matthew R. Moore, Marie-Claude Bon, Zachary Lahey, Cheryl G. Roberts, Lynn A. Combee, Natalie McGathey, Simon van Noort, Alexander V. Timokhov, Evelyne Hougardy, Brian Hogg   +11 more
doaj   +3 more sources

Use of Broken-Symmetry Density Functional Theory To Characterize the IspH Oxidized State: Implications for IspH Mechanism and Inhibition [PDF]

Journal of Chemical Theory and Computation, 2014
With current therapies becoming less efficacious due to increased drug resistance, new inhibitors of both bacterial and malarial targets are desperately needed. The recently discovered methylerythritol phosphate (MEP) pathway for isoprenoid synthesis provides novel targets for the development of such drugs.
Blachly, Patrick G, Sandala, Gregory M, Giammona, Debra Ann, Liu, Tiqing, Bashford, Donald, McCammon, J Andrew, Noodleman, Louis   +6 more
openaire   +4 more sources

The prevalence of SARS-CoV-2 infection and other public health outcomes during the BA.2/BA.2.12.1 surge, New York City, April–May 2022

Communications Medicine, 2023
Background Routine case surveillance data for SARS-CoV-2 are incomplete, unrepresentative, missing key variables of interest, and may be increasingly unreliable for timely surge detection and understanding the true burden of infection.
Saba A. Qasmieh, McKaylee M. Robertson, Chloe A. Teasdale, Sarah G. Kulkarni, Heidi E. Jones, David A. Larsen, John J. Dennehy, Margaret McNairy, Luisa N. Borrell, Denis Nash   +9 more
doaj   +1 more source

Towards pseudo-spectral incompressible smoothed particle hydrodynamics (ISPH) [PDF]

Computer Physics Communications, 2021
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Georgios Fourtakas, Benedict D. Rogers, Abouzied M. A. Nasar   +2 more
openaire   +3 more sources