Results 11 to 20 of about 2,497 (152)

Utilizing a dynamical description of IspH to aid in the development of novel antimicrobial drugs. [PDF]

PLoS Computational Biology, 2013
The nonmevalonate pathway is responsible for isoprenoid production in microbes, including H. pylori, M. tuberculosis and P. falciparum, but is nonexistent in humans, thus providing a desirable route for antibacterial and antimalarial drug discovery.
Patrick G Blachly, César A F de Oliveira, Sarah L Williams, J Andrew McCammon   +3 more
doaj   +3 more sources

Comparison of different iterative schemes for ISPH based on Rankine source solution [PDF]

International Journal of Naval Architecture and Ocean Engineering, 2017
Smoothed Particle Hydrodynamics (SPH) method has a good adaptability for the simulation of free surface flow problems. There are two forms of SPH. One is weak compressible SPH and the other one is incompressible SPH (ISPH).
Xing Zheng, Qing-wei Ma, Wen-yang Duan
doaj   +2 more sources

Incompressible smoothed particle hydrodynamics (ISPH) modelling of breakwater overtopping

, 2014
This paper describes an investigation into using incompressible smoothed particle hydrodynamics (ISPH) to simulate the overtopping of a coastal structure such as a breakwater.
Stansby, Peter K., Skillen, Alex; id_orcid, Morellec, Maël, Rogers, Benedict D.; id_orcid   +3 more
core   +10 more sources

Resonance Raman Spectroscopic Study of the Unusual [4Fe-4S]²⁺ Cluster of IspH, the Last Enzyme of the Methylerythritol Phosphate Pathway for Terpenoid Biosynthesis. [PDF]

Chembiochem
Raman spectroscopy confirms that the apical Fe atom of the [4Fe‐4S]2+ cluster of IspH is linked to H2O molecules and that the (E)‐4‐hydroxy‐3‐methyl‐but‐2‐en‐1‐yl diphosphate substrate and the propargyl diphosphate inhibitor lead to a change of coordination geometry. The loss of octahedral coordination of the apical Fe atom is also very likely when the
Jobelius H, Chaignon P, Bianchino GI, Wandzig J, Hellwig P, Seemann M, Melin F.   +6 more
europepmc   +2 more sources

Engineering Cyanobacteria for High-Yield Photosynthetic Isoprene Production With Long-Term Phenotypic Stability. [PDF]

Plant Biotechnol J
Center: Cyanobacterial isoprene production from CO2 and sunlight. Top: CRISPR‐editing for generation of markerless production strains. Top right: Long‐term production assay for strain stability assessment. Bottom right: Engineering of MEP pathway and surrounding metabolism for bottleneck idenfication. Bottom left: Relief of bottleneck by overproduction
Janssen KN, Bolay P, Tüllinghoff A, Toepel J, Spindler D, Bühler B, Lindberg P.   +6 more
europepmc   +2 more sources

Eulerian ISPH Method for Simulating Internal Flows [PDF]

Journal of Applied Fluid Mechanics, 2016
In this article the possibility to use Eulerian approach in the conventional ISPH method in simulation of internal fluid flows is studied. The use of Eulerian approach makes it possible to use non-uniform particle distributions to increase the resolution
Mani Ordoubadi, Asghar Farhadi, Firoozeh Yeganehdoust, Homayoon Emdad, Mahmood Yaghoubi, Ebrahim Goshtasebi Rad   +5 more
doaj   +1 more source

The prevalence of SARS-CoV-2 infection and other public health outcomes during the BA.2/BA.2.12.1 surge, New York City, April–May 2022

Communications Medicine, 2023
Background Routine case surveillance data for SARS-CoV-2 are incomplete, unrepresentative, missing key variables of interest, and may be increasingly unreliable for timely surge detection and understanding the true burden of infection.
Saba A. Qasmieh, McKaylee M. Robertson, Chloe A. Teasdale, Sarah G. Kulkarni, Heidi E. Jones, David A. Larsen, John J. Dennehy, Margaret McNairy, Luisa N. Borrell, Denis Nash   +9 more
doaj   +1 more source

A maximalist approach to the systematics of a biological control agent: Gryon aetherium Talamas, sp. nov. (Hymenoptera, Scelionidae) [PDF]

Journal of Hymenoptera Research, 2021
A morphological and molecular analysis of Gryon Haliday (Platygastroidea, Scelionidae) was conducted to provide a taxonomic and phylogenetic context for a species under evaluation as a biological control agent of Bagrada hilaris (Burmeister) (Hemiptera ...
Elijah J. Talamas, Jonathan S. Bremer, Matthew R. Moore, Marie-Claude Bon, Zachary Lahey, Cheryl G. Roberts, Lynn A. Combee, Natalie McGathey, Simon van Noort, Alexander V. Timokhov, Evelyne Hougardy, Brian Hogg   +11 more
doaj   +3 more sources

ISPH Only

, 2022
Plots of Cases 1 - 8 showing ISPH results comparing 3 resolutions 
Alex Chow (4602985)
core   +1 more source

Substitution of CH₃ by CH₂F in 2-Methylerythritol Cyclodiphosphate Triggers Potent Inhibition of IspG with Concomitant Fluoride Ion Expulsion. [PDF]

Chemistry
The fluoromethyl analogue of MEcPP was identified as a very potent inhibitor of the oxygen‐sensitive [4Fe‐4S] metalloenzyme IspG. In the course of the IspG‐catalyzed transformation, this novel compound undergoes fluoride elimination, offering additional evidence for the involvement of a carbanionic intermediate in the mechanism of this enzyme ...
Witjaksono C, Herrscher V, Jobelius H, Noël N, Massicot F, Vasse JL, Behr JB, Seemann M.   +7 more
europepmc   +2 more sources