Results 1 to 10 of about 32,260 (214)

CLPX acquires an iron-sulfur cluster to sustain mitochondrial proteostasis in cancer cells [PDF]

Nature Communications
Mitochondrial proteostasis-maintaining mechanisms are crucial for protecting cells from the toxicity of misfolded protein accumulation. Although excessive stress is known to inactivate these mechanisms and thereby induce mitophagy in cancer cells, the ...
Chengquan Huang, Yixue Zhang, Han Gao, Yuxin Song, Shunchang Hu, Chaoyue Sun, Shiwen Duan, Dongxiao Ma, Xiumei Jiang, Gang Liu   +9 more
doaj   +2 more sources

Structural and biochemical investigations of a HEAT-repeat protein involved in the cytosolic iron-sulfur cluster assembly pathway [PDF]

Communications Biology, 2023
Iron-sulfur clusters are essential for life and defects in their biosynthesis lead to human diseases. The mechanism of cluster assembly and delivery to cytosolic and nuclear client proteins via the cytosolic iron-sulfur cluster assembly (CIA) pathway is ...
Sheena Vasquez, Melissa D. Marquez, Edward J. Brignole, Amanda Vo, Sunnie Kong, Christopher Park, Deborah L. Perlstein, Catherine L. Drennan   +7 more
doaj   +2 more sources

Modulation of MagR magnetic properties via iron–sulfur cluster binding

Scientific Reports, 2021
Iron–sulfur clusters are essential cofactors found in all kingdoms of life and play essential roles in fundamental processes, including but not limited to respiration, photosynthesis, and nitrogen fixation.
Zhen Guo, Shuai Xu, Xue Chen, Changhao Wang, Peilin Yang, Siying Qin, Cuiping Zhao, Fan Fei, Xianglong Zhao, Ping-Heng Tan, Junfeng Wang, Can Xie   +11 more
doaj   +1 more source

Regulation of Mitochondrial Energy Metabolism by Glutaredoxin 5 in the Apicomplexan Parasite Neospora caninum

Microbiology Spectrum, 2023
Iron-sulfur [Fe-S] clusters are one of the most ancient and functionally versatile natural biosynthetic prosthetic groups required by various proteins involved in important metabolic processes, including the oxidative phosphorylation of proteins ...
Xingju Song, Xu Yang, Zhu Ying, Kaijian Wu, Jing Liu, Qun Liu   +5 more
doaj   +1 more source

Constraint-based modeling of yeast mitochondria reveals the dynamics of protein import and iron-sulfur cluster biogenesis

iScience, 2021
Summary: Mitochondria are a hallmark of eukaryal cells and play an important role in cellular metabolism. There is a vast amount of knowledge available on mitochondrial metabolism and essential mitochondrial functions, such as protein import and iron ...
Carl Malina, Francesca Di Bartolomeo, Eduard J. Kerkhoven, Jens Nielsen   +3 more
doaj   +1 more source

Structure of a putative immature form of a Rieske-type iron-sulfur protein in complex with zinc chloride

Communications Chemistry, 2023
Iron-sulfur clusters are prosthetic groups of proteins involved in various biological processes. However, details of the immature state of the iron-sulfur cluster into proteins have not yet been elucidated. We report here the first structural analysis of
Erika Tsutsumi, Satomi Niwa, Ryota Takeda, Natsuki Sakamoto, Kei Okatsu, Shuya Fukai, Hideo Ago, Satoshi Nagao, Hiroshi Sekiguchi, Kazuki Takeda   +9 more
doaj   +1 more source

Crystallographic characterization of the high-potential iron-sulfur protein in the oxidized state at 0.8 Å resolution. [PDF]

PLoS ONE, 2017
High-potential iron-sulfur protein (HiPIP) is a soluble electron carrier protein of photosynthetic bacteria with an Fe4S4 cluster. Although structural changes accompanying the electron transfer are important for understanding of the functional mechanism,
Hiraku Ohno, Kazuki Takeda, Satomi Niwa, Tomotaka Tsujinaka, Yuya Hanazono, Yu Hirano, Kunio Miki   +6 more
doaj   +1 more source

Sulfur Administration in Fe–S Cluster Homeostasis

Antioxidants, 2021
Mitochondria are the key organelles of Fe–S cluster synthesis. They contain the enzyme cysteine desulfurase, a scaffold protein, iron and electron donors, and specific chaperons all required for the formation of Fe–S clusters.
Leszek Rydz, Maria Wróbel, Halina Jurkowska   +2 more
doaj   +1 more source

Biophysical Characterization of Iron-Sulfur Proteins

Bio-Protocol, 2021
Iron-sulfur proteins are primordial catalysts and biological electron carriers that today drive major metabolic pathways across all forms of life. They can access a diversity of oxidation states and can mediate electron transfer over an extended range of
Bhanu Jagilinki, Irina Paluy, Alexei Tyryshkin, Vikas Nanda, Dror Noy   +4 more
doaj   +1 more source

Iron–Sulfur Cluster Biogenesis and Iron Homeostasis in Cyanobacteria

Frontiers in Microbiology, 2020
Iron–sulfur (Fe–S) clusters are ancient and ubiquitous cofactors and are involved in many important biological processes. Unlike the non-photosynthetic bacteria, cyanobacteria have developed the sulfur utilization factor (SUF) mechanism as their main ...
Fudan Gao
doaj   +1 more source