Results 21 to 30 of about 32,260 (214)

The Molecular Bases of the Dual Regulation of Bacterial Iron Sulfur Cluster Biogenesis by CyaY and IscX

Frontiers in Molecular Biosciences, 2018
IscX (or YfhJ) is a protein of unknown function which takes part in the iron-sulfur cluster assembly machinery, a highly specialized and essential metabolic pathway. IscX binds to iron with low affinity and interacts with IscS, the desulfurase central to
Salvatore Adinolfi, Rita Puglisi, Jason C. Crack, Clara Iannuzzi, Clara Iannuzzi, Fabrizio Dal Piaz, Petr V. Konarev, Petr V. Konarev, Dmitri I. Svergun, Stephen Martin, Nick E. Le Brun, Annalisa Pastore, Annalisa Pastore   +12 more
doaj   +1 more source

Escherichia coli RIC is able to donate iron to iron-sulfur clusters. [PDF]

PLoS ONE, 2014
Escherichia coli RIC (Repair of Iron Centers) is a diiron protein previously reported to be involved in the repair of iron-sulfur proteins damaged by oxidative or nitrosative stresses, and proposed to act as an iron donor.
Lígia S Nobre, Ricardo Garcia-Serres, Smilja Todorovic, Peter Hildebrandt, Miguel Teixeira, Jean-Marc Latour, Lígia M Saraiva   +6 more
doaj   +1 more source

Probing the coordination and function of Fe4S4 modules in nitrogenase assembly protein NifB

Nature Communications, 2018
NifB is a key enzyme in the biosynthesis pathway of the nitrogenase FeMo cofactor. Here, the authors investigate the maturation of its iron-sulfur clusters by EPR and biochemical analyses, showing how individual precursor clusters participate in the ...
Lee A. Rettberg, Jarett Wilcoxen, Chi Chung Lee, Martin T. Stiebritz, Kazuki Tanifuji, R. David Britt, Yilin Hu   +6 more
doaj   +1 more source

A [4Fe-4S] cluster resides at the active center of phosphomevalonate dehydratase, a key enzyme in the archaeal modified mevalonate pathway

Frontiers in Microbiology, 2023
The recent discovery of the archaeal modified mevalonate pathway revealed that the fundamental units for isoprenoid biosynthesis (isopentenyl diphosphate and dimethylallyl diphosphate) are biosynthesized via a specific intermediate, trans ...
Mutsumi Komeyama, Kohsuke Kanno, Hiroyuki Mino, Yoko Yasuno, Tetsuro Shinada, Tomokazu Ito, Hisashi Hemmi   +6 more
doaj   +1 more source

TusA influences Fe-S cluster assembly and iron homeostasis in E. coli by reducing the translation efficiency of Fur

Microbiology Spectrum
All sulfur transfer pathways have generally a l-cysteine desulfurase as an initial sulfur-mobilizing enzyme in common, which serves as a sulfur donor for the biosynthesis of numerous sulfur-containing biomolecules in the cell.
Paolo Olivieri, Arkadiuz Zupok, Tugba Yildiz, Jonathan Oltmanns, Angelika Lehmann, Ewelina Sokolowska, Aleksandra Skirycz, Volker Schünemann, Silke Leimkühler   +8 more
doaj   +1 more source

Evolutionary conservation and in vitro reconstitution of microsporidian iron–sulfur cluster biosynthesis

Nature Communications, 2017
The functions of the highly reduced mitochondria (mitosomes) of microsporidians are not well-characterized. Here, the authors show that theTrachipleistophora hominismitosome is the site of iron–sulfur cluster assembly and that its retention is likely ...
Sven-A. Freibert, Alina V. Goldberg, Christian Hacker, Sabine Molik, Paul Dean, Tom A. Williams, Sirintra Nakjang, Shaojun Long, Kacper Sendra, Eckhard Bill, Eva Heinz, Robert P. Hirt, John M Lucocq, T. Martin Embley, Roland Lill   +14 more
doaj   +1 more source

Genetic/metabolic effect of iron metabolism and rare anemias

Thalassemia Reports, 2013
Advances in iron metabolism have allowed a novel classification of iron disorders and to identify previously unknown diseases. These disorders include genetic iron overload (hemochromatosis) and inherited iron-related anemias, in some cases accompanied ...
Clara Camaschella
doaj   +1 more source

Role of GSH and Iron-Sulfur Glutaredoxins in Iron Metabolism—Review

Molecules, 2020
Glutathione (GSH) was initially identified and characterized for its redox properties and later for its contributions to detoxification reactions. Over the past decade, however, the essential contributions of glutathione to cellular iron metabolism have ...
Trnka Daniel, Hossain Md Faruq, Jordt Laura Magdalena, Gellert Manuela, Lillig Christopher Horst   +4 more
doaj   +1 more source

The iron-sulfur cluster is essential for DNA binding by human DNA polymerase ε

Scientific Reports, 2022
DNA polymerase ε (Polε) is a key enzyme for DNA replication in eukaryotes. Recently it was shown that the catalytic domain of yeast Polε (PolεCD) contains a [4Fe-4S] cluster located at the base of the processivity domain (P-domain) and coordinated by ...
Alisa E. Lisova, Andrey G. Baranovskiy, Lucia M. Morstadt, Nigar D. Babayeva, Elena I. Stepchenkova, Tahir H. Tahirov   +5 more
doaj   +1 more source

The therapeutic opportunities and pitfalls of using iron ion chelators to treat neurodegenerative diseases

FEBS Letters, EarlyView.
Although too much iron in the brain promotes neurodegeneration, iron ion chelators have had mixed effects in clinical trials. This review explains why; some chelators do not render the iron redox‐inactive (e.g., L1) whereas others do (e.g., desferrioxamine).
Barry Halliwell
wiley   +1 more source