Results 31 to 40 of about 1,904,807 (242)
Iron-Sulfur Clusters: A Core Hub in Insect Energy, Reproduction, and Molting
InsectsIron-sulfur clusters are a class of functionally diverse protein cofactors. In recent years, significant progress has been made in insect research on iron-sulfur clusters, revealing that they serve as a core molecular hub that integrate multiple ...
Xiao-Han Di +3 more
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Probing the coordination and function of Fe4S4 modules in nitrogenase assembly protein NifB
Nature Communications, 2018 NifB is a key enzyme in the biosynthesis pathway of the nitrogenase FeMo cofactor. Here, the authors investigate the maturation of its iron-sulfur clusters by EPR and biochemical analyses, showing how individual precursor clusters participate in the ...
Lee A. Rettberg +6 more
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Frontiers in Microbiology, 2023 The recent discovery of the archaeal modified mevalonate pathway revealed that the fundamental units for isoprenoid biosynthesis (isopentenyl diphosphate and dimethylallyl diphosphate) are biosynthesized via a specific intermediate, trans ...
Mutsumi Komeyama +6 more
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Characterisation of XPD from Sulfolobus acidocaldarius : an iron-sulphur cluster containing DNA repair helicase [PDF]
, 2007 DNA is constantly damaged by a variety of exogenous and endogenous sources. To maintain the integrity of the genome, different DNA repair mechanisms have evolved, which deal with different kinds of DNA damage.
Rudolf, Jana
core +2 more sources
Microbiology SpectrumAll sulfur transfer pathways have generally a l-cysteine desulfurase as an initial sulfur-mobilizing enzyme in common, which serves as a sulfur donor for the biosynthesis of numerous sulfur-containing biomolecules in the cell.
Paolo Olivieri +8 more
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Nature Communications, 2017 The functions of the highly reduced mitochondria (mitosomes) of microsporidians are not well-characterized. Here, the authors show that theTrachipleistophora hominismitosome is the site of iron–sulfur cluster assembly and that its retention is likely ...
Sven-A. Freibert +14 more
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FEBS Letters, EarlyView.Synechocystis strains deficient in succinate dehydrogenase (SDH) secrete more succinate than the WT under dark anaerobic conditions, supporting that SDH then primarily acts as SDH, not as a fumarate reductase. L‐aspartate oxidase (Laspo) from Synechocystis is functional under anaerobic conditions, reducing fumarate to succinate.
Kateryna Kukil +3 more
wiley +1 more source
Genetic/metabolic effect of iron metabolism and rare anemias
Thalassemia Reports, 2013 Advances in iron metabolism have allowed a novel classification of iron disorders and to identify previously unknown diseases. These disorders include genetic iron overload (hemochromatosis) and inherited iron-related anemias, in some cases accompanied ...
Clara Camaschella
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Role of GSH and Iron-Sulfur Glutaredoxins in Iron Metabolism—Review
Molecules, 2020 Glutathione (GSH) was initially identified and characterized for its redox properties and later for its contributions to detoxification reactions. Over the past decade, however, the essential contributions of glutathione to cellular iron metabolism have ...
Trnka Daniel +4 more
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The iron-sulfur cluster is essential for DNA binding by human DNA polymerase ε
Scientific Reports, 2022 DNA polymerase ε (Polε) is a key enzyme for DNA replication in eukaryotes. Recently it was shown that the catalytic domain of yeast Polε (PolεCD) contains a [4Fe-4S] cluster located at the base of the processivity domain (P-domain) and coordinated by ...
Alisa E. Lisova +5 more
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