Results 31 to 40 of about 81,685 (258)

The Molecular Bases of the Dual Regulation of Bacterial Iron Sulfur Cluster Biogenesis by CyaY and IscX

Frontiers in Molecular Biosciences, 2018
IscX (or YfhJ) is a protein of unknown function which takes part in the iron-sulfur cluster assembly machinery, a highly specialized and essential metabolic pathway. IscX binds to iron with low affinity and interacts with IscS, the desulfurase central to
Salvatore Adinolfi, Rita Puglisi, Jason C. Crack, Clara Iannuzzi, Clara Iannuzzi, Fabrizio Dal Piaz, Petr V. Konarev, Petr V. Konarev, Dmitri I. Svergun, Stephen Martin, Nick E. Le Brun, Annalisa Pastore, Annalisa Pastore   +12 more
doaj   +1 more source

Escherichia coli RIC is able to donate iron to iron-sulfur clusters. [PDF]

PLoS ONE, 2014
Escherichia coli RIC (Repair of Iron Centers) is a diiron protein previously reported to be involved in the repair of iron-sulfur proteins damaged by oxidative or nitrosative stresses, and proposed to act as an iron donor.
Lígia S Nobre, Ricardo Garcia-Serres, Smilja Todorovic, Peter Hildebrandt, Miguel Teixeira, Jean-Marc Latour, Lígia M Saraiva   +6 more
doaj   +1 more source

TtcA a new tRNA-thioltransferase with an Fe-S cluster [PDF]

, 2014
International audienceTtcA catalyzes the post-transcriptional thiolation of cytosine 32 in some tRNAs. The enzyme from Es-cherichia coli was homologously overexpressed in E. coli.
Atta, Mohamed, Bouvier, Denis, Clémancey, Martin, Fontecave, Marc, Labessan, Natty, Latour, Jean-Marc, Ravanat, Jean-Luc   +6 more
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Probing the coordination and function of Fe4S4 modules in nitrogenase assembly protein NifB

Nature Communications, 2018
NifB is a key enzyme in the biosynthesis pathway of the nitrogenase FeMo cofactor. Here, the authors investigate the maturation of its iron-sulfur clusters by EPR and biochemical analyses, showing how individual precursor clusters participate in the ...
Lee A. Rettberg, Jarett Wilcoxen, Chi Chung Lee, Martin T. Stiebritz, Kazuki Tanifuji, R. David Britt, Yilin Hu   +6 more
doaj   +1 more source

Opposite Regulatory Effects of Iron Ions on the In Vitro Catalytic Activities of NarE, the Toxin-like ADP-ribosyltransferase from Neisseria meningitidis [PDF]

, 2015
NarE, the mono ADP-ribosyltransferase identified in Neisseria meningitidis, catalyzes three enzymatic reactions. NarE transfers a single ADP-ribose unit to guanidine compounds, hydrolyses NAD in nicotinamide and free ADP-ribose, and ADP-ribosylates ...
Balducci, Enrico, Del Vecchio, Mariangela   +1 more
core   +1 more source

A [4Fe-4S] cluster resides at the active center of phosphomevalonate dehydratase, a key enzyme in the archaeal modified mevalonate pathway

Frontiers in Microbiology, 2023
The recent discovery of the archaeal modified mevalonate pathway revealed that the fundamental units for isoprenoid biosynthesis (isopentenyl diphosphate and dimethylallyl diphosphate) are biosynthesized via a specific intermediate, trans ...
Mutsumi Komeyama, Kohsuke Kanno, Hiroyuki Mino, Yoko Yasuno, Tetsuro Shinada, Tomokazu Ito, Hisashi Hemmi   +6 more
doaj   +1 more source

TusA influences Fe-S cluster assembly and iron homeostasis in E. coli by reducing the translation efficiency of Fur

Microbiology Spectrum
All sulfur transfer pathways have generally a l-cysteine desulfurase as an initial sulfur-mobilizing enzyme in common, which serves as a sulfur donor for the biosynthesis of numerous sulfur-containing biomolecules in the cell.
Paolo Olivieri, Arkadiuz Zupok, Tugba Yildiz, Jonathan Oltmanns, Angelika Lehmann, Ewelina Sokolowska, Aleksandra Skirycz, Volker Schünemann, Silke Leimkühler   +8 more
doaj   +1 more source

Evolutionary conservation and in vitro reconstitution of microsporidian iron–sulfur cluster biosynthesis

Nature Communications, 2017
The functions of the highly reduced mitochondria (mitosomes) of microsporidians are not well-characterized. Here, the authors show that theTrachipleistophora hominismitosome is the site of iron–sulfur cluster assembly and that its retention is likely ...
Sven-A. Freibert, Alina V. Goldberg, Christian Hacker, Sabine Molik, Paul Dean, Tom A. Williams, Sirintra Nakjang, Shaojun Long, Kacper Sendra, Eckhard Bill, Eva Heinz, Robert P. Hirt, John M Lucocq, T. Martin Embley, Roland Lill   +14 more
doaj   +1 more source

Glutaredoxin GRXS17 associates with the cytosolic iron-sulfur cluster assembly pathway [PDF]

, 2016
Cytosolic monothiol glutaredoxins (GRXs) are required in iron-sulfur (Fe-S) cluster delivery and iron sensing in yeast and mammals. In plants, it is unclear whether they have similar functions.
Cammue, Bruno PA, De Clercq, Rebecca, De Coninck, Barbara, De Jaeger, Geert, Fernie, Alisdair R, Gevaert, Kris, Goossens, Alain, Iñigo, Sabrina, Klassen, Roland, Le Gall, Sabine, Leidel, Sebastian A, Nagels Durand, Astrid, Pauwels, Laurens, Ritter Traub, Andrés, Schaffrath, Raffael, Termathe, Martin, Tohge, Takayuki, Van Leene, Jelle, Van Lijsebettens, Maria   +18 more
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Genetic/metabolic effect of iron metabolism and rare anemias

Thalassemia Reports, 2013
Advances in iron metabolism have allowed a novel classification of iron disorders and to identify previously unknown diseases. These disorders include genetic iron overload (hemochromatosis) and inherited iron-related anemias, in some cases accompanied ...
Clara Camaschella
doaj   +1 more source