Results 41 to 50 of about 1,904,807 (242)

Smaller is better: nanobodies meet NMR

FEBS Letters, EarlyView.
Nanobodies are single‐domain antigen‐binding fragments derived from camelid heavy chain antibodies. Their small size, high stability, and exceptional specificity make nanobodies uniquely useful probes for NMR studies of protein dynamics, transient conformational states, and protein–protein interactions.
Oleg Y. Dmitriev
wiley   +1 more source

Iron and sulfur utilisation patterns in chemolithotrophic cultures [PDF]

, 2012
In this study, the growth and behaviour of chemolithotrophic organisms in the presence of both ferrous and tetrathionate ions was investigated. Given the impact of chemolithotrophic metabolic activity upon the chemistry and leaching of mineral sulfide ...
Shiers, Denis
core  

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

BCG vaccination potentiates oxidative phosphorylation in neonatal myeloid‐derived suppressor cells

FEBS Open Bio, EarlyView.
BCG vaccination enhances oxidative phosphorylation in neonatal MDSCs, impairing their immunosuppressive function. It upregulates electron transport chain genes and mitochondrial activity, increasing ATP and oxygen consumption. Pharmacological OXPHOS inhibition partially restores suppressive capacity, confirming causality.
Yingying Chen, Hui Li
wiley   +1 more source

The effects of Mary Rose conservation treatment on iron oxidation processes and microbial communities contributing to acid production in marine archaeological timbers [PDF]

, 2014
The Tudor warship the Mary Rose has reached an important transition point in her conservation. The 19 year long process of spraying with polyethylene glycol (PEG) has been completed (April 29(th) 2013) and the hull is air drying under tightly controlled ...
Preston, Joanne, Preston Joanne, Smith, Andrew, Smith AD, Jones Mark A., Joy E. M. Watts (124946), Alan V Chadwick, Schofield, Eleanor J., Joanne Preston, Chadwick AV, Chadwick Alan V., Jones MA, Andrew D. Smith (494170), Watts, Joy, Eleanor J. Schofield (524683), Jones, Mark, Joanne Preston (524682), Mark A Jones, Smith Andrew D., Watts JEM, Schofield, Eleanor, Chadwick, Alan, Schofield EJ, Watts Joy E. M., Jones, Mark A., Mark A. Jones (524685), Smith, Andrew D., Chadwick, Alan V., Eleanor J Schofield, Joy E M Watts, Watts, Joy E. M., Schofield Eleanor J., Andrew D Smith, Alan V. Chadwick (524684), Preston J   +34 more
core   +1 more source

Genetic dissection of human ABCE1 in yeast reveals separable requirements for ribosome recycling and suppression of aberrant reinitiation

FEBS Open Bio, EarlyView.
Human ABCE1 cannot functionally replace its yeast ortholog. Yeast–human chimera analysis identified NBD1 as a major interspecies barrier. Genetic screening yielded hABCE1 revertants that rescue yeast viability but fail to suppress aberrant translation reinitiation in the 3′ UTR.
Eriko Nakata, Yuxin Li, Kei Endo, Koichi Ito   +3 more
wiley   +1 more source

Recent insights into the molecular mechanism of ubiquinol oxidation by cytochrome bc1

FEBS Open Bio, EarlyView.
The review reflects on the mechanism of the catalytic reaction in cytochrome bc1: the electron bifurcation that involves the separation of two electrons derived from the quinol oxidation to opposite sides of the enzyme across the membrane. This review summarizes the long‐standing effort to understand the mechanism of quinol oxidation catalyzed by ...
Anna Wójcik‐Augustyn, Artur Osyczka, Marcin Sarewicz   +2 more
wiley   +1 more source

Zinc Toxicity and Iron-Sulfur Cluster Biogenesis in Escherichia coli [PDF]

, 2019
While zinc is an essential trace metal in biology, excess zinc is toxic to organisms. Previous studies have shown that zinc toxicity is associated with disruption of the (4Fe-4S] clusters in various dehydratases in Escherichia coli.
Ding, Huangen
core   +1 more source

Machine Learning‐Supported Analysis for Predicting and Visualizing Nonlinear Relationships Between Material Properties in Electroplated Chromium Layers

Advanced Engineering Materials, EarlyView.
This study applies machine learning regression to predict chromium layer thickness in decorative trivalent chromium electroplating, using 441 experiments from laboratory‐scale (1L) and pilot‐scale (14L) setups. Tree‐based models, particularly CatBoost, outperformed linear regression by capturing nonlinear parameter interactions (R2$R^2$ up to 0.77 ...
Christoph Baumer, Christopher Mai, Luca Eisentraut, Andreas Bund, Ricardo Buettner   +4 more
wiley   +1 more source

Iron-sulfur Cluster Biogenesis and Iron Homeostasis in Escherichia coli [PDF]

, 2018
Iron-sulfur clusters as key cofactors are involved in multiple cellular processes, such as central metabolism and respiration, gene regulation and DNA repair. In Escherichia coli, iron-sulfur clusters are assembled by a group of dedicated proteins. While
Yang, Jing
core   +1 more source