Results 61 to 70 of about 1,259,729 (236)

Chiral Nanoparticles Suppress Inflammatory Infiltration to Promote Extracellular Matrix Remodeling for Ectopia Lentis Therapy

Advanced Science, EarlyView.
L‐cysteine‐configured chiral polyurethane nanoparticles suppress ocular inflammation and reduce extracellular matrix (ECM) degradation in ectopia lentis by regulating macrophages polarization and inhibiting nuclear factor kappa B signaling pathway. By promoting zonular fiber‐associated protein restoration and tissue repair, this minimally invasive ...
Yinuo Wen, Yan Yang, Haihan Gao, Yan Liu, Xinyue Wang, Linghao Song, Ruohong Li, Ao Miao, Jie Xu, Zhennan Zhao, Dan Li, Shenjie Peng, Linzhao Li, Min Zhang, Yonghang Liu, Liren Wang, Tianhui Chen, Yongxiang Jiang   +17 more
wiley   +1 more source

Orbital Engineering of π-d Conjugation in One-Dimensional Metal-Organic Materials for Lithium-Ion Batteries: A DFT Study. [PDF]

Chemphyschem
π‐d conjugation in 1D Ni‐MOPs is governed by two key factors: the choice of bridging heteroatom and ligand functionalization. Sulfur bridges maximize orbitals overlap with Ni d states, while electron‐withdrawing groups improve energy level alignment, together enhancing orbital hybridization, charge delocalization, and electrochemical performance ...
Li M, Zhao D, Zhang L, Yang P, Han F, Wu Z, Zhang S, Wang Y.   +7 more
europepmc   +2 more sources

Paternal Sperm Gnas‐ICR Epigenetic Programming Contributes to PPP‐Like Phenotypes in Female Offspring

Advanced Science, EarlyView.
A paternal glucocorticoid–sperm Gnas‐ICR axis is linked to ovarian endocrine programming in female offspring. Paternal preconception caffeine exposure elevates corticosterone, promotes sperm Gnas‐ICR hypermethylation, and is associated with ovarian Gnas upregulation, cAMP/PKA/CREB–StAR activation, enhanced estradiol synthesis, and PPP‐like phenotypes ...
Jing Huang, Lu Chen, Tiancheng Wu, Yating Li, Hui Wang   +4 more
wiley   +1 more source

SLIT3-mediated intratumoral crosstalk induces neuroblastoma differentiation via a spontaneous regression-like program

Journal of Translational Medicine
Background Neuroblastoma, the most common pediatric extracranial solid tumor, has heterogeneous clinical outcomes ranging from malignant progression to spontaneous regression.
Meiling Liu, Dekang Lv, Wenjing Yan, Yi Wu, Shulan Wang, Luoxuan Wang, Jie Lei, Deshun Zeng, Zifeng Wang, Fang Liu, Bing Deng, Quentin Liu, Bin He, Min Yan   +13 more
doaj   +1 more source

Crystal structure and absolute configuration of (3aS,4S,5R,7aR)-2,2,7-trimethyl-3a,4,5,7a-tetrahydro-1,3-benzodioxole-4,5-diol

Acta Crystallographica Section E: Crystallographic Communications, 2015
The absolute configuration of the title compound, C10H16O4, determined as 3aS,4S,5R,7aR on the basis of the synthetic pathway, was confirmed by X-ray diffraction.
Mario A. Macías, Leopoldo Suescun, Enrique Pandolfi, Valeria Schapiro, Gaurao D. Tibhe, Álvaro W. Mombrú   +5 more
doaj   +1 more source

Targeting GALNT7 Disrupts the TAZ O‐GalNAcylation Feedback Loop to Suppress Gallbladder Cancer Progression

Advanced Science, EarlyView.
Aberrant GALNT7‐mediated O‐GalNAcylation stabilizes TAZ to drive gallbladder cancer progression through a feed‐forward transcriptional loop. Structure‐based screening identifies Olaparib as a potent GALNT7 antagonist that disrupts this oncogenic axis, providing an immediate therapeutic strategy for this aggressive malignancy.
Peng Qiu, Ming Zhang, Yunxiang Feng, Yibo Deng, Kai Zhao, Xiangyu Li, Yun Lu, Li Tian, Tao Yang, Wei Yao, Jianming Wang, Zhengdong Deng   +11 more
wiley   +1 more source

Modified MXene Aerogel With Broadband Microwave Absorption Inspired by Melanophila Acuminata Beetle

Advanced Science, EarlyView.
This work introduces a novel biomimetic strategy inspired by the infrared‐sensing sensilla of the Melanophila acuminata beetle. We have designed a multi‐level aerogel, featuring a three‐dimensional carbon framework decorated with synergistic CeO2 nanoparticles and Ti3C2Tx MXene nanosheets.
Zhiwei Liu, Dingyu Xu, Zhaobo Liu, Haitian Song, Qianqian Zhang, Junxiao Zhou, Xiewen Wen   +6 more
wiley   +1 more source

Adaptive Cu Reconstruction in Heterostructure Drives High‐Rate Nitrate‐to‐Ammonia Conversion

Advanced Science, EarlyView.
An adaptively reconstructed Cu/CoOX heterojunction, featuring a surface‐localized, hydroxyl‐rich oxidized Cu species, forms in situ from a CuO/CoOX (Co1Cu9OX) pre‐catalyst during electrochemical nitrate reduction. The self‐adaptive reconstruction and the incorporation of heterostructure regulate nitrogen‐containing intermediate adsorption and *H supply,
Chunyu Yuan, Saikat Bolar, Yongzheng Zhang, Akitaka Ito, Tatsuhiko Ohto, Takeshi Fujita   +5 more
wiley   +1 more source

Probing enzymes late in the trypanosomal glycosylphosphatidylinositol biosynthetic pathway with synthetic glycosylphosphatidylinositol analogues [PDF]

, 2008
Glycosylphosphatidylinositol (GPI)-anchored proteins are abundant in the protozoan parasite Trypanosoma brucei, the causative agent of African sleeping sickness in humans and the related disease Nagana in cattle, and disruption of GPI biosynthesis is ...
Nikolaev, Andrei V., Crossman, Arthur, Ferguson, Michael A. J., Yashunsky, Dmitry V., Urbaniak, Michael D.   +4 more
core   +3 more sources

Genetic and metabolic engineering approaches for enhanced biodesulfurization of petroleum fractions

Frontiers in Bioengineering and Biotechnology
Sulfur, an abundant component of crude oil, causes severe damage to the environment, poses risks to human health, and poisons the catalysts used in combustion engines.
Asheemita Bagchi, Preeti Srivastava
doaj   +1 more source