Results 61 to 70 of about 155,151 (257)
Arthritis Care &Research, EarlyView.Systemic sclerosis (SSc) is a rare autoimmune disease defined by immune dysregulation, vasculopathy, and progressive fibrosis of the skin and internal organs. Despite advances in care, major complications such as interstitial lung disease (ILD) and myocardial involvement remain the leading causes of morbidity and mortality.
Cristiana Sieiro Santos +2 more
wiley +1 more source
Utilizing a dynamical description of IspH to aid in the development of novel antimicrobial drugs. [PDF]
PLoS Computational Biology, 2013 The nonmevalonate pathway is responsible for isoprenoid production in microbes, including H. pylori, M. tuberculosis and P. falciparum, but is nonexistent in humans, thus providing a desirable route for antibacterial and antimalarial drug discovery.
Patrick G Blachly +3 more
doaj +1 more source
Interaction of the Streptomyces Wbl protein WhiD with the principal sigma factor σHrdB depends on the WhiD [4Fe-4S] cluster [PDF]
, 2020 The bacterial protein WhiD belongs to the Wbl family of iron–sulfur [Fe-S] proteins present only in the actinomycetes. In Streptomyces coelicolor, it is required for the late stages of sporulation, but precisely how it functions is unknown.
Bush, Matthew +4 more
core +1 more source
Ferroelectricity in Antiferromagnetic Wurtzite Nitrides
Advanced Functional Materials, EarlyView.We establish MnSiN2${\rm MnSiN}_2$ and MnGeN2${\rm MnGeN}_2$ as aristotypes of a new multiferroic wurtzite family that simultaneously exhibits ferroelectricity and antiferromagnetism with altermagnetic spin splitting. By strategically substituting alkaline‐earth metals, we predict new materials with coexisting switchable polarization, spin texture, and
Steven M. Baksa +3 more
wiley +1 more source
A bacteria-specific 2[4Fe-4S] ferredoxin is essential in
BMC Microbiology, 2010 Background Ferredoxins are small iron-sulfur proteins belonging to all domains of life. A sub-group binds two [4Fe-4S] clusters with unequal and extremely low values of the reduction potentials.
Diallinas George +5 more
doaj +1 more source
LOSS OF DIFFERENTIATING NEMATOCYTES INDUCED BY REGENERATION AND WOUND HEALING IN HYDRA [PDF]
, 1984 Cell death was observed in the nematocyte differentiation pathway in Hydra during head and foot regeneration. This death occurs throughout the regenerating piece, is transient in nature and is selective for committed stenotele and desmoneme precursors ...
David, Charles N., Fujisawa, Toshitaka
core
Differentiated, promoter-specific response of [4Fe-4S] NsrR DNA-binding to reaction with nitric oxide [PDF]
, 2016 NsrR is an iron-sulfur cluster protein that regulates the nitric oxide (NO) stress response of many bacteria. NsrR from Streptomyces coelicolor regulates its own expression and that of only two other genes, hmpA1 and hmpA2, which encode HmpA enzymes ...
Crack, Jason +5 more
core +1 more source
Nanodiamond Quantum Sensors for Probing Free Radical Biology
Advanced Functional Materials, EarlyView.Free radicals play key roles in cellular signaling and disease but remain difficult to measure in living systems. Nanodiamonds (NDs) with nitrogen‐vacancy (NV) centers enable quantum sensing of local magnetic noise via T₁ relaxometry, providing nondestructive radical detection in living cells.
Qi Lu, Yingke Wu, Tanja Weil
wiley +1 more source
Structural insight on the mechanism of an electron-bifurcating [FeFe] hydrogenase
eLife, 2022 Electron bifurcation is a fundamental energy conservation mechanism in nature in which two electrons from an intermediate-potential electron donor are split so that one is sent along a high-potential pathway to a high-potential acceptor and the other is ...
Chris Furlan +6 more
doaj +1 more source
Unravelling the Secret of Sulfur Confinement and High Sulfur Utilization in Hybrid Sulfur‐Carbons
Advanced Materials, EarlyView.Thermal condensation of inverse vulcanized sulfur‐carbon hybrids enables a bottom‐up sulfur confinement strategy, in which a protective carbon phase is progressively constructed around sulfur species. The resulting carbon nanodomains covalently tether sulfur chains and stabilize radical intermediates. This integrated architecture effectively suppresses
Tim Horner +9 more
wiley +1 more source