Results 51 to 60 of about 117,075 (151)

Fasciola hepatica Surface Coat Glycoproteins Contain Mannosylated and Phosphorylated N-glycans and Exhibit Immune Modulatory Properties Independent of the Mannose Receptor. [PDF]

PLoS Neglected Tropical Diseases, 2016
Fascioliasis, caused by the liver fluke Fasciola hepatica, is a neglected tropical disease infecting over 1 million individuals annually with 17 million people at risk of infection. Like other helminths, F.
Alessandra Ravidà, Allison M Aldridge, Nicole N Driessen, Ferry A H Heus, Cornelis H Hokke, Sandra M O'Neill   +5 more
doaj   +1 more source

Synthesis and Antitumor Evaluation of Menthone-Derived Pyrimidine-Urea Compounds as Potential PI3K/Akt/mTOR Signaling Pathway Inhibitor

Frontiers in Chemistry, 2022
A series of novel menthone derivatives bearing pyrimidine and urea moieties was designed and synthesized to explore more potent natural product-derived antitumor agents. The structures of the target compounds were confirmed by FTIR, NMR, and HRMS. The in
Mei Huang, Mei Huang, Wengui Duan, Naiyuan Chen, Naiyuan Chen, Guishan Lin, Xiu Wang   +6 more
doaj   +1 more source

SLIT3-mediated intratumoral crosstalk induces neuroblastoma differentiation via a spontaneous regression-like program

Journal of Translational Medicine
Background Neuroblastoma, the most common pediatric extracranial solid tumor, has heterogeneous clinical outcomes ranging from malignant progression to spontaneous regression.
Meiling Liu, Dekang Lv, Wenjing Yan, Yi Wu, Shulan Wang, Luoxuan Wang, Jie Lei, Deshun Zeng, Zifeng Wang, Fang Liu, Bing Deng, Quentin Liu, Bin He, Min Yan   +13 more
doaj   +1 more source

Crystal structure and absolute configuration of (3aS,4S,5R,7aR)-2,2,7-trimethyl-3a,4,5,7a-tetrahydro-1,3-benzodioxole-4,5-diol

Acta Crystallographica Section E: Crystallographic Communications, 2015
The absolute configuration of the title compound, C10H16O4, determined as 3aS,4S,5R,7aR on the basis of the synthetic pathway, was confirmed by X-ray diffraction.
Mario A. Macías, Leopoldo Suescun, Enrique Pandolfi, Valeria Schapiro, Gaurao D. Tibhe, Álvaro W. Mombrú   +5 more
doaj   +1 more source

Comparative analysis of biodesulfurization of dibenzothiophene (DBT) and 4,6-dimethyl dibenzothiophene (4,6-DMDBT) by 4S pathway using molecular simulations

Preparative Biochemistry & Biotechnology
In this paper, we have analyzed biodesulfurization of dibenzothiophene (DBT) and 4,6-dibenzothiophene (4,6-DMDBT) by 4S metabolic pathway using molecular simulations. Docking analysis revealed lower binding energies and inhibition constants (Ki) for 4,6-DMDBT and its metabolic intermediates with DSZ enzymes than DBT and its intermediates. The complexes
Pushpita, Das, , Umesh, Lepakshi, Barbora, Vijayanand Suryakant, Moholkar   +3 more
openaire   +2 more sources

Genetic and metabolic engineering approaches for enhanced biodesulfurization of petroleum fractions

Frontiers in Bioengineering and Biotechnology
Sulfur, an abundant component of crude oil, causes severe damage to the environment, poses risks to human health, and poisons the catalysts used in combustion engines.
Asheemita Bagchi, Preeti Srivastava
doaj   +1 more source

Integrated Omics Approaches to Explore a New System of Genetic Control of Dibenzothiophene Desulfurization and Aromatic Ring Cleavage by Gordonia alkanivorans Strain 135

Biology
Dibenzothiophene (DBT) is a widespread environmental pollutant. The most common metabolic pathway for DBT degradation by Gordonia strains is the 4S pathway, which is under the control of the dsz operon.
Ekaterina Frantsuzova, Alexander Bogun, Anna Vetrova, Elizaveta Kazakova, Tomiris Kusainova, Irina Tarasova, Irina Pozdnyakova-Filatova, Yanina Delegan   +7 more
doaj   +1 more source

Ubiquinone Biosynthesis over the Entire O₂ Range: Characterization of a Conserved O₂-Independent Pathway

mBio, 2019
Most bacteria can generate ATP by respiratory metabolism, in which electrons are shuttled from reduced substrates to terminal electron acceptors, via quinone molecules like ubiquinone.
Ludovic Pelosi, Chau-Duy-Tam Vo, Sophie Saphia Abby, Laurent Loiseau, Bérengère Rascalou, Mahmoud Hajj Chehade, Bruno Faivre, Mathieu Goussé, Clothilde Chenal, Nadia Touati, Laurent Binet, David Cornu, Cameron David Fyfe, Marc Fontecave, Frédéric Barras, Murielle Lombard, Fabien Pierrel   +16 more
doaj   +1 more source

Characteristics of dibenzothiophene desulfurization by Rhodococcus erythropolis R1 and its Dsz-negative mutant

Biological Journal of Microorganism, 2014
Introduction: Biodesulfurization is used as a selective method for lowering the sulfur content of petroleum products. Materials and methods: A sulfur-oxidation bacterial strain named Rhodococcus erythropolis R1 (NCBI GenBank Accession No.
Zahra Etemadifar , Simone Cappello, Seyed Hamid Zarkesh-Esfahani   +2 more
doaj  

Intracellular peroxynitrite perturbs redox balance, bioenergetics, and Fe–S cluster homeostasis in Mycobacterium tuberculosis

Redox Biology
The ability of Mycobacterium tuberculosis (Mtb) to tolerate nitric oxide (•NO) and superoxide (O2•−) produced by phagocytes contributes to its success as a human pathogen.
Arshiya Dewan, Charu Jain, Mayashree Das, Ashutosh Tripathi, Ajay Kumar Sharma, Harshit Singh, Nitish Malhotra, Aswin Sai Narain Seshasayee, Harinath Chakrapani, Amit Singh   +9 more
doaj   +1 more source