Results 31 to 40 of about 12,456,978 (213)

Autoantibodies to Cytosolic 5′-Nucleotidase 1A in Primary Sjögren’s Syndrome and Systemic Lupus Erythematosus

Frontiers in Immunology, 2018
Introduction Autoantibodies to cytosolic 5′-nucleotidase 1A (cN-1A; NT5C1A) have a high specificity when differentiating sporadic inclusion body myositis from polymyositis and dermatomyositis.
A. Rietveld, L. L. van den Hoogen, N. Bizzaro, S. Blokland, C. Dähnrich, J. Gottenberg, G. Houen, N. Johannsen, T. Mandl, A. Meyer, C. Nielsen, P. Olsson, J. V. van Roon, W. Schlumberger, B. V. van Engelen, C. Saris, G. Pruijn   +16 more
semanticscholar   +1 more source

Cytosolic 5′-nucleotidase 1A autoantibody profile and clinical characteristics in inclusion body myositis

Annals of the Rheumatic Diseases, 2017
Objectives Autoantibodies directed against cytosolic 5′-nucleotidase 1A have been identified in many patients with inclusion body myositis. This retrospective study investigated the association between anticytosolic 5′-nucleotidase 1A antibody status and
J. Lilleker, J. Lilleker, A. Rietveld, S. Pye, K. Mariampillai, O. Benveniste, M. Peeters, J. Miller, M. Hanna, P. Machado, M. Parton, K. Gheorghe, U. Badrising, I. Lundberg, S. Sacconi, M. Herbert, N. McHugh, B. Lecky, C. Brierley, D. Hilton‐Jones, J. Lamb, M. Roberts, R. Cooper, R. Cooper, R. Cooper, C. Saris, G. Pruijn, H. Chinoy, H. Chinoy, H. Chinoy, B. Engelen   +30 more
semanticscholar   +1 more source

5′-Nucleotidase and AMP-deaminase activities of liver postnuclear fraction and blood serum of rats with transplanted Guerin’s carcinoma

Біологічні студії, 2009
The dynamics of the levels of 5′-nucleotidase and AMP-deaminase activity in postnuclear fraction of rat liver and serum was studied during transplanted Guerin’s carcinoma growth in rats.
H. P. Kopylchuk, I. M. Buchkovska, O. M. Voloschuk   +2 more
doaj   +1 more source

ACTIVITY OF AMP DEAMINASE AND 5′-NUCLEOTIDASE IN THE CYTOSOLIC KIDNEY FRACTION OF RATS UNDER THE CONDITIONS OF DIFFERENT PROTEIN AND SUCROSE CONTENT IN A DIET [PDF]

Biotechnologia Acta, 2022
Aim. The goal of this work was to evaluate the activity of AMP deaminase and 5′-nucleotidase in the cytosolic kidney fraction of rats under the conditions of different protein and sucrose content in a diet./ Methods. In the study, 10-12 week old white
A. S. Boichu, O. M. Voloshchuk
doaj   +1 more source

Streptococcus suis synthesizes deoxyadenosine and adenosine by 5’-nucleotidase to dampen host immune responses

Virulence, 2018
Streptococcus suis is a major porcine bacterial pathogen and emerging zoonotic agent. S. suis 5ʹ-nucleotidase is able to convert adenosine monophosphate to adenosine, resulting in inhibiting neutrophil functions in vitro and it is an important virulence ...
Jiao Dai, L. Lai, Huanyu Tang, Weixue Wang, Shuoyue Wang, Chengping Lu, Huochun Yao, H. Fan, Zongfu Wu   +8 more
semanticscholar   +1 more source

Cell type- and tissue-specific functions of ecto-5'-nucleotidase (CD73).

Am J Physiol Cell Physiol, 2019
CD73 is a ubiquitously-expressed glycosylphosphatidylinositol (GPI)-anchored glycoprotein that converts extracellular adenosine 5'-monophosphate (AMP) to adenosine.
Minor M, Alcedo KP, Battaglia RA, Snider NT.   +3 more
europepmc   +2 more sources

ATP- and Adenosine-Mediated Signaling in the Central Nervous System: Adenosine Receptor Activation by ATP Through Rapid and Localized Generation of Adenosine by Ecto-nucleotidases

Journal of Pharmacological Sciences, 2004
Extracellular ATP is now recognized as a neurotransmitter or neuromodilator in the nervous system, producing diverse physiological effects by activating multiple P2 receptors.
Isao Matsuoka, Satoko Ohkubo
doaj   +1 more source

Pyrimidine 5’Nucleotidase I and II Activities in Acute Leukaemias

Acta Medica, 2004
Summary: Bacground and objective: Pyrimidine 5’nucleotidase I and II activities of peripheral mononuclear cells were studied to evaluate their role in diagnosis, assessment of therapy and follow up of remission in acute leukaemias.
Haci Kemal Erdemli, Bahattin Adam, Nüket Bavbek   +2 more
doaj   +1 more source

Synthesis of novel (E)-1-(2-(2-(4(dimethylamino) benzylidene) hydrazinyl)-4-methylthiazol-5-yl)ethanone derivatives as ecto-5′-nucleotidase inhibitors [PDF]

Royal Society Open Science, 2018
Ecto-5′-nucleotidase (e5′NT), a membrane-bound enzyme and an essential member of ecto-nucleotidases which regulates extracellular purinergic signalling.
Sidra Hassan, Pervaiz Ali Channar, Fayaz Ali Larik, Aamer Saeed, Hamid Saeed Shah, Joanna Lecka, Jean Sévigny, Jamshed Iqbal   +7 more
doaj   +1 more source

Fluorine‐18‐Labeled Nucleotide Analogs Targeting Ecto‐5'‐Nucleotidase (CD73) for Positron Emission Tomography Imaging of Solid Tumors

Angewandte Chemie, EarlyView.
Fluorine‐18‐labeled CD73 inhibitor [18F]PSB‐19427 enables noninvasive PET mapping of CD73 overexpression in triple‐negative breast (TNBC) and pancreatic cancer. For [18F]PSB‐19427, specific binding in human tumor tissues, favorable biodistribution with prolonged blood retention, robust tumor uptake, and superiority to [18F]FDG in a TNBC model ...
Clemens Dobelmann, Constanze C. Schmies, Georg Wilhelm Rolshoven, Mirko Scortichini, Stefan Wagner, Andreas Isaak, Riham M. Idris, Jennifer Dabel, Lucie Grey, Karolina Losenkova, Susanne Moschütz, Haneen Al Hroub, Antje Keim, Sandra Höppner, Jouko Sandholm, Pia Boström, Maija Hollmén, Norbert Sträter, Sven Hermann, Gennady G. Yegutkin, Kenneth A. Jacobson, Sonja Schelhaas, Christa E. Müller, Anna Junker   +23 more
wiley   +2 more sources