Results 61 to 70 of about 12,456,978 (213)

Zebrafish as a model for Catel–Manzke syndrome—identification and characterization of the zebrafish TGDS ortholog

open access: yesThe FEBS Journal, EarlyView.
Zebrafish Tgds, when expressed as a recombinant protein, catalyzes the dehydration of UDP‐D‐glucose, the initial step in the formation of 6‐deoxyhexoses. Corresponding Tgds mutations found in Catel–Manzke syndrome patients lead to reduced enzymatic activity and stability.
Maria Rosaria Coppola   +11 more
wiley   +1 more source

A review on laboratory liver function tests [PDF]

open access: yesThe Pan African Medical Journal, 2009
Laboratory liver tests are broadly defined as tests useful in the evaluation and treatment of patients with hepatic dysfunction. The liver carries out metabolism of carbohydrate, protein and fats. Some of the enzymes and the end products of the metabolic
Shruthi Kulkarni   +5 more
doaj  

Canine Leishmaniasis in Rio de Janeiro, Brazil (2000–2015): Taxonomic Characterisation of Etiological Agents and Geospatial Case Analysis

open access: yesZoonoses and Public Health, EarlyView.
ABSTRACT Introduction Canine Leishmaniasis is a vector‐borne zoonotic disease caused by several species of protozoa of the genus Leishmania. In the state of Rio de Janeiro (RJ), Leishmania braziliensis is the most prevalent species causing tegumentary leishmaniasis (TL) and Leishmania infantum is the main causative agent of visceral leishmaniasis (VL).
Luciana de Freitas Campos Miranda   +10 more
wiley   +1 more source

Consequences of the Lack of CD73 and Prostatic Acid Phosphatase in the Lymphoid Organs

open access: yesMediators of Inflammation, 2014
CD73, ecto-5′-nucleotidase, is the key enzyme catalyzing the conversion of extracellular AMP to adenosine that controls vascular permeability and immunosuppression.
Gennady G. Yegutkin   +10 more
doaj   +1 more source

Dysregulation of CD39/Ectonucleoside Triphosphate Diphosphohydrolase 1 Causes Urinary Bladder Dysfunction with Abnormal Smooth Muscle Contractility

open access: yesThe FASEB Journal, Volume 40, Issue 7, 15 April 2026.
Abnormal extracellular ATP levels cause lower urinary tract symptoms (LUTS). Here, we demonstrate that overexpression of ENTPD1 (CD39TG)—an ATP/ADP converting enzyme—reduces voiding frequency while increasing void volume. Conversely, ENTPD1 deficiency results in frequent, small‐volume voiding.
Zhaobo Luo   +7 more
wiley   +1 more source

Features of the oxidation processes and state of microcirculatory channel have persons exposed to low doses of ionizing radiation

open access: yesБюллетень сибирской медицины, 2012
We have examined 36 liquidators (participants in emergency clean-up after the Chernobylnuclear accident) many years after the external γ-irradiation (on average (143.0 ± 14.0) mGy for (3.3 ± 0.8) months) and 13 workers of a typical research nuclear ...
Ya. V. Porovsky   +3 more
doaj   +1 more source

A randomized phase II trial of gemcitabine, nab‐paclitaxel, cisplatin with or without a medically supervised ketogenic diet for patients with metastatic pancreatic cancer

open access: yesCancer, Volume 132, Issue 6, 15 March 2026.
ABSTRACT Background A randomized phase II screening trial of gemcitabine, nab‐paclitaxel, and cisplatin with a medically supervised ketogenic diet (MSKD) versus usual diet (non‐MSKD) was conducted in patients with treatment‐naive metastatic pancreatic ductal adenocarcinoma (PDAC).
Gayle S. Jameson   +21 more
wiley   +1 more source

Analysis of the NTPDase and ecto-5'-nucleotidase profiles in serum-limited Trichomonas vaginalis

open access: yesMemorias do Instituto Oswaldo Cruz, 2012
Trichomonas vaginalis is a parasite of the human urogenital tract that causes trichomonosis, the most prevalent non-viral sexually transmitted disease. Ectonucleoside triphosphate diphosphohydrolase (NTPDase) family members, which hydrolyse extracellular
Amanda Piccoli Frasson   +8 more
doaj   +1 more source

Cytokine‐Engineered Chimeric Antigen Receptor‐T Cell Therapy: How to Balance the Efficacy and Toxicity

open access: yesAdvanced Science, Volume 13, Issue 14, 9 March 2026.
Cytokine‐engineered CAR‐T cells represent a promising immunotherapy against malignancies due to direct tumor killing and potent immunity response. However, significant toxicities, including CRS and ICANS, have restricted clinical applications. How to keep the risk‐benefit balance of the advanced therapy is of great importance for maximizing the benefit
Xinru Zhang   +7 more
wiley   +1 more source

Lead Poisoning Revealed by Unexplained Abdominal Pain and Anemia in a Young Adult: A Diagnostic Challenge

open access: yesClinical Case Reports, Volume 14, Issue 3, March 2026.
ABSTRACT Lead poisoning should be considered in patients presenting with unexplained anemia and abdominal pain, even without clear environmental or occupational exposure. Recognizing classic signs such as Burton's line and basophilic stippling enables timely diagnosis and effective chelation therapy.
Jennifer Eichler   +2 more
wiley   +1 more source

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