Results 71 to 80 of about 134,477 (121)

Functional and structural basis of extreme conservation in vertebrate 5' untranslated regions. [PDF]

Nat Genet, 2021
Byeon GW, Cenik ES, Jiang L, Tang H, Das R, Barna M.   +5 more
europepmc   +1 more source

Targeting 3' and 5' untranslated regions with antisense oligonucleotides to stabilize frataxin mRNA and increase protein expression. [PDF]

Nucleic Acids Res, 2021
Li Y, Li J, Wang J, Lynch DR, Shen X, Corey DR, Parekh D, Bhat B, Woo C, Cherry JJ, Napierala JS, Napierala M.   +11 more
europepmc   +1 more source

A Luciferase-Based Approach for Functional Screening of 5′ and 3′ Untranslated Regions of the mRNA Component for mRNA Vaccines

Vaccines
Background/Objectives: The recent COVID-19 pandemic caused by SARS-CoV-2 infection has highlighted the need for protocols for rapid development of efficient screening methods to search for the optimal mRNA vaccine structures against mutable viral agents.
Maria Rubtsova, Yuliana Mokrushina, Dmitry Andreev, Maria Poteshnova, Nikita Shepelev, Mariya Koryagina, Ekaterina Moiseeva, Diana Malabuiok, Yury Prokopenko, Stanislav Terekhov, Aleksander Chernov, Elena Vodovozova, Ivan Smirnov, Olga Dontsova, Alexander Gabibov, Yury Rubtsov   +15 more
doaj   +1 more source

Investigating 5’ untranslated regions and translational regulation across human genes

Untranslated regions (UTRs) are important mediators of post-transcriptional regulation. The length of UTRs and the composition of regulatory elements within them are known to vary substantially across genes, but the reasons remain poorly understood in ...
Tatz-Wieder, Nechama
core   +1 more source

Mutational Analysis ofCis-Acting Sequences in the 3′- and 5′-Untranslated Regions of RNA2 of Red Clover Necrotic Mosaic Virus

, 1999
Mutational analysis has been used to investigatecis-acting sequences in the 3′- and 5′-untranslated regions of red clover necrotic mosaic virus RNA2 required for replication in the presence of wild-type RNA1.
Turner, Roisin L., Buck, Kenneth W.
core   +1 more source

A new combination of 5’- and 3’-untranslated regions increases the expression of mRNAs in vitro and in vivo

Вавиловский журнал генетики и селекции
mRNA vaccine technologies have been actively developing since the beginning of the 21st century and have received a major boost from new findings about the functioning of the immune system and the development of efficient vehicles for nucleic acid ...
D. N. Antropov, O. V. Markov, A. S. Dome, P. A. Puchkov, E. V. Shmendel, D. V. Gladkikh, V. M. Golyshev, A. M. Matveeva, M. A. Maslov, G. A. Stepanov   +9 more
doaj   +1 more source

Intron size, abundance, and distribution within untranslated regions of genes

, 2006
Most research concerning the evolution of introns has largely considered introns within coding sequences (CDSs), without regard for introns located within untranslated regions (UTRs) of genes.
Lynch, Michael, Hong, Xin, Scofield, Douglas   +2 more
core   +1 more source

PLoS One [PDF]

A type 2 vaccine-derived poliovirus (VDPV), differing from the Sabin 2 strain at 8.6% (78/903) of VP1 nucleotide positions, was isolated from seawater collected from a seaport in S\ue3o Paulo State, Brazil.

core  

HuB serves as the central hub for connecting HuR-related mRNAs with translation machinery in inflammation

Communications Biology
The mRNAs of inflammatory factors often contain unstable AU-rich elements (AREs) within their 3’ untranslated regions (3’UTRs), and HuR is a key ARE-binding protein to recognize such elements.
Jing Zhang, Ximan Huang, Yunhan Tang, Xiyue Zhong, Jing Wang, Min Wei, Xiaoqing Han, Yueshuang Ke, Xueqing Ba   +8 more
doaj   +1 more source

Biophysical characterization of honey bee virus untranslated regions

Over the past two decades, honey bee colony losses have become a serious and widespread issue. Many factors contribute to these losses, but one major driver is viruses.
University of Lethbridge. Faculty of Arts and Science, Letain, Jenna M.   +1 more
core