Results 1 to 10 of about 345,197 (240)

The Roles of Picornavirus Untranslated Regions in Infection and Innate Immunity

Frontiers in Microbiology, 2018
Viral genomes have evolved to maximize their potential of overcoming host defense mechanisms and to induce a variety of disease syndromes. Structurally, a genome of a virus consists of coding and noncoding regions, and both have been shown to contribute ...
Anna Kloc, Devendra K. Rai, Elizabeth Rieder   +2 more
doaj   +2 more sources

MicroRNA genes and their target 3'-untranslated regions are infrequently somatically mutated in ovarian cancers. [PDF]

PLoS ONE, 2012
MicroRNAs are key regulators of gene expression and have been shown to have altered expression in a variety of cancer types, including epithelial ovarian cancer.
Georgina L Ryland, Jennifer L Bearfoot, Maria A Doyle, Samantha E Boyle, David Y H Choong, Simone M Rowley, Australian Ovarian Cancer Study Group, Richard W Tothill, Kylie L Gorringe, Ian G Campbell   +9 more
doaj   +2 more sources

Intragenomic rearrangements involving 5′-untranslated region segments in SARS-CoV-2, other betacoronaviruses, and alphacoronaviruses

Virology Journal, 2023
Background Variation of the betacoronavirus SARS-CoV-2 has been the bane of COVID-19 control. Documented variation includes point mutations, deletions, insertions, and recombination among closely or distantly related coronaviruses.
Roberto Patarca, William A. Haseltine
doaj   +1 more source

Regulatory processes that control haploid expression of salmon sperm mRNAs

BMC Research Notes, 2018
Objective Various stages of mRNA processing are necessary for functionally important genes required during late-stage sperm differentiation. Protein–RNA complexes form that edit, stabilize, store, deliver, localize and regulate translation of sperm mRNAs.
Kristian R. von Schalburg, Eric B. Rondeau, Jong S. Leong, William S. Davidson, Ben F. Koop   +4 more
doaj   +1 more source

Generation of Sequencing Libraries for Structural Analysis of Bacterial 5′ UTRs

STAR Protocols, 2020
Summary: The structure of 5′ untranslated regions (5′ UTRs) of bacterial mRNAs often determines the fate of the transcripts. Using a dimethyl sulfate mutational profiling with sequencing (DMS-MaPseq) approach, we developed a protocol to generate sequence
Dmitriy Ignatov, Karolis Vaitkevicius, Jörgen Johansson   +2 more
doaj   +1 more source

5′ UTR variant in the NDP gene leads to incorrect splicing and familial exudative vitreoretinopathy

Orphanet Journal of Rare Diseases
Background  Familial exudative vitreoretinopathy (FEVR) represents a clinically and genetically diverse ophthalmic disorder marked by incomplete development of retinal blood vessels. The NDP gene predominantly underlies X-linked FEVR. Methods Copy number
Siping Liu, Ke Xiong, Xin Jiang, Lijun Tang, Leyi Chen, Yihong Li, Bei Jia   +6 more
doaj   +1 more source

Two Classes of Highly Similar Coiled Coil-Nucleotide Binding-Leucine Rich Repeat Genes Isolated from the Rps1-k Locus Encode Phytophthora Resistance in Soybean

Molecular Plant-Microbe Interactions, 2005
A series of single genes protect soybean from the root and stem disease caused by the oomycete pathogen Phytophthora sojae. In the last two decades, Rps1-k has been the most stable and widely used Phytophthora resistance gene for the major soybean ...
Hongyu Gao, Narayanan N. Narayanan, Lori Ellison, Madan K. Bhattacharyya   +3 more
doaj   +1 more source

Comparative analysis of hepatitis C virus phylogenies from coding and non-coding regions: the 5' untranslated region (UTR) fails to classify subtypes

Virology Journal, 2006
Background The duration of treatment for HCV infection is partly indicated by the genotype of the virus. For studies of disease transmission, vaccine design, and surveillance for novel variants, subtype-level classification is also needed.
Leitner Thomas, Bruno William J, Fischer William, Hraber Peter T, Kuiken Carla   +4 more
doaj   +1 more source

Genetic polymorphism analysis of 5' untranslated region of thyroglobulin gene in Bali cattle (Bos javanicus) from three different regions of Indonesia

Journal of the Indonesian Tropical Animal Agriculture, 2017
The g.422C>T nucleotide variations in the 5’ untranslated region (5’UTR) of TG gene (called as TG5) has been reported to be associated with level in intramuscular fat (IMF) content or marbling in beef cattle.
S. Anwar, A.C. Putra, A.S. Wulandari, P. P. Agung, W.P.B. Putra, S. Said   +5 more
doaj   +1 more source

Design of in vitro Transcribed mRNA Vectors for Research and Therapy

CHIMIA, 2019
The use of in vitro transcribed messenger RNA (ivt mRNA) for vaccination, gene therapy and cell reprograming has become increasingly popular in research and medicine.
Marina Tusup, Lars E. French, Mara De Matos, David Gatfield, Thomas Kundig, Steve Pascolo   +5 more
doaj   +1 more source