Results 141 to 150 of about 1,582 (168)

A specific folate activates serotonergic neurons to control C. elegans behavior. [PDF]

Nat Commun
Peesapati RS, Austin-Byler BL, Nawaz FZ, Stevenson JB, Mais SA, Kaya RN, Hassan MG, Khanal N, Wells AC, Ghiai D, Garikapati AK, Selhub J, Kipreos ET.   +12 more
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Identification of 5,6,7,8-tetrahydropterin and 5,6,7,8-tetrahydrobiopterin in Drosophila melanogaster

Biochemical and Biophysical Research Communications, 1988
Using reversed-phase high-performance liquid chromatography with electrochemical detection we have demonstrated the occurrence of 5,6,7,8-tetrahydropterin and 5,6,7,8-tetrahydrobiopterin in Drosophila melanogaster. The former is the first time that has been detected in vivo.
J J, Guillamón, J, Ferré
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Decrease in 6R-5,6,7,8-tetrahydrobiopterin content in cerebrospinal fluid of autistic patients

Neuroscience Letters, 1994
The levels of pterin compounds in the lumbar cerebrospinal fluid (CSF) of ten neurologically normal and twenty autistic children were measured by two different liquid chromatographic systems, a conventional and a newly developed direct method. Among pterin compounds 7,8-dihydroneopterin (NH2) and 6R-5,6,7,8-tetrahydrobiopterin (R-BH4) levels in ...
Y, Tani, E, Fernell, Y, Watanabe, T, Kanai, B, Långström   +4 more
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Conformational investigation of the cofactor (6R,1′R,2′S-)-5,6,7,8-tetrahydrobiopterin

Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology, 1995
(6R,1'R,2'S)-5,6,7,8-Tetrahydrobiopterin is an essential cofactor for several enzymes. Different theoretical models (molecular mechanics, semiempirical quantum chemical calculations) investigating its stereostructure have yielded diverging answers. To clarify these issues, combined molecular mechanical and ab initio quantum chemical calculations were ...
W, Estelberger, D, Fuchs, C, Murr, H, Wachter, G, Reibnegger   +4 more
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6R-l-Erythro-5,6,7,8-tetrahydrobiopterin as a regulator of dopamine and serotonin biosynthesis in the rat brain

Archives of Biochemistry and Biophysics, 1985
6R-L-Erythro-tetrahydrobiopterin (6R-BH4), the natural isomer of tetrahydrobiopterin, was synthesized from 7,8-dihydrobiopterin using dihydrofolate reductase. The effects of intracerebroventricular injection of 6R-BH4 on the biosyntheses of neurotransmitter monoamines in the rat brain were investigated by measuring accumulation of 3,4 ...
S, Miwa, Y, Watanabe, O, Hayaishi
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Enhancement of acetylcholine release in the hippocampus by 6R--erythro-5,6,7,8-tetrahydrobiopterin is mediated by 5-hydroxytryptamine

Brain Research, 1993
Recently, we reported that 6R-L-erythro-tetrahydrobiopterin (6R-BH4), a natural cofactor for L-aromatic amino acid hydroxylases, enhances in vivo release of acetylcholine (ACh) in the rat hippocampus: the enhancement was abolished after depletion of brain catecholamines and 5-hydroxytryptamine (5-HT) by pretreatment with reserpine. In the present study,
T, Ohue, K, Koshimura, Y, Takagi, Y, Watanabe, S, Miwa, T, Masaki   +5 more
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Antioxidative Activity of 5,6,7,8-Tetrahydrobiopterin and its Inhibitory Effect on Paraquat-Induced Cell Toxicity in Cultured Rat Hepatocytes

Free Radical Research, 1995
The in vitro antioxidative activity of 5,6,7,8-tetrahydrobiopterin (BPH4) was measured and the ability of BPH4 to prevent paraquat-induced cell damage was examined in cultured hepatocytes. The scavenging activity of BPH4 against superoxide anion radicals was assayed in two systems, i.e., xanthine/xanthine oxidase (X/XOD) and rat macrophage/phorbol ...
S, Kojima, S, Ona, I, Iizuka, T, Arai, H, Mori, K, Kubota   +5 more
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Photophysics of 5,6,7,8-tetrahydrobiopterin on a femtosecond time-scale

Journal of Photochemistry and Photobiology B: Biology
Pterins are naturally occurring compounds widespread in living organisms. 5,6,7,8-Tetrahydrobiopterin (H4Bip) is a cofactor of several key enzymes, including NO-synthases and phenylalanine hydroxylase, whereas tetrahydrocyanopterin is a photoreceptor molecule in cyanobacteria.
Varvara G, Kubenko, Vladimir A, Pomogaev, Andrey A, Buglak, Alexei I, Kononov   +3 more
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Chiral Recognition at the Heme Active Site of Nitric Oxide Synthase Is Markedly Enhanced byl-Arginine and 5,6,7,8-Tetrahydrobiopterin

Biochemical and Biophysical Research Communications, 1998
The effects of substrate, L-Arg and cofactors, (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin (H4B) and calmodulin (CaM), on chiral discrimination by rat neuronal nitric oxide synthase (nNOS) for binding the enantiomers of 1-(1-naphthyl)ethylamine (ligand I), 1-cyclohexylethylamine (ligand II), and 1-(4-pyridyl)ethanol (ligand III) were studied under ...
K, Nakano, I, Sagami, S, Daff, T, Shimizu   +3 more
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